Search Results - "Varrone, A."

Test–retest reproducibility of [11C]PBR28 binding to TSPO in healthy control subjects by Collste, K., Forsberg, A., Varrone, A., Amini, N., Aeinehband, S., Yakushev, I., Halldin, C., Farde, L., Cervenka, S.

“…Purpose The PET radioligand [ 11 C]PBR28 binds to the translocator protein (TSPO), a marker of brain immune activation. We examined the reproducibility of [ 11…”
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The immune response of the human brain to abdominal surgery by Forsberg, Anton, Cervenka, Simon, Jonsson Fagerlund, Malin, Rasmussen, Lars S., Zetterberg, Henrik, Erlandsson Harris, Helena, Stridh, Pernilla, Christensson, Eva, Granström, Anna, Schening, Anna, Dymmel, Karin, Knave, Nina, Terrando, Niccolò, Maze, Mervyn, Borg, Jacqueline, Varrone, Andrea, Halldin, Christer, Blennow, Kaj, Farde, Lars, Eriksson, Lars I.

“…Objective Surgery launches a systemic inflammatory reaction that reaches the brain and associates with immune activation and cognitive decline. Although…”
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Longitudinal DAT changes measured with [18F]FE-PE2I PET in patients with Parkinson’s disease; a validation study by Kerstens, V.S., Fazio, P., Sundgren, M., Brumberg, J., Halldin, C., Svenningsson, P., Varrone, A.

“…•[18F]FE-PE2I measures of DAT decline in PD agree with other radioligands.•It has, however, improved effect sizes for measuring intraindividual DAT…”
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Dopamine transporter imaging in neurodegenerative movement disorders: PET vs. SPECT by Kerstens, Vera S., Varrone, A.

“…Purpose The dopamine transporter (DAT) serves as biomarker for parkinsonian syndromes. DAT can be measured in vivo with single-photon emission computed…”
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Longitudinal DAT changes measured with [18F]FE-PE2I PET in patients with Parkinson?s disease; a validation study by Kerstens, VS, Fazio, P, Sundgren, M, Brumberg, J, Halldin, C, Svenningsson, P, Varrone, A

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Development of a novel fluorine-18 labeled deuterated fluororasagiline ([18F]fluororasagiline-D2) radioligand for PET studies of monoamino oxidase B (MAO-B) by Nag, S., Lehmann, L., Kettschau, G., Toth, M., Heinrich, T., Thiele, A., Varrone, A., Halldin, C.

“…Fluorine-18 labeled deuterated analogue of fluororasagiline for detection of MAO-B activity by PET. The objective of this study was to synthesize and evaluate…”
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Blood Flow Dependence of Early [C-11]PE2I and [F-18]FE-PE2I PET SUVR Measurements Used In the Differential Diagnosis of Parkinsonian Disorders by Jonasson, My, Langaas, G., Appel, Lieuwe, Danfors, Torsten, Fazio, P., Lubberink, Mark, Varrone, A.

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New developments of dopaminergic imaging in Parkinson's disease by Varrone, A, Halldin, C

“…The development of radioligands for the dopaminergic system has provided suitable imaging biomarkers for clinical research in Parkinson's disease (PD) and…”
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Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: Validation using postmortem autoradiography data by Fazio, P., Schain, M., Varnäs, K., Halldin, C., Farde, L., Varrone, A.

“…The human brainstem is a complex structure with several small nuclei and neural pathways of interest in the pathophysiology of central nervous system (CNS)…”
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Synthesis and evaluation of [18F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B) by Nag, S., Lehmann, L., Kettschau, G., Heinrich, T., Thiele, A., Varrone, A., Gulyas, B., Halldin, C.

“…Development of novel PET radioligand for MAO-B. The aim of this study was to synthesize and evaluate a novel fluorine-18 labeled analogue of rasagiline (6) as…”
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Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain by Finnema, S.J., Varrone, A., Hwang, T.J., Gulyás, B., Pierson, M.E., Halldin, C., Farde, L.

“…The need for positron emission tomography (PET)‐radioligands that are sensitive to changes in endogenous serotonin (5‐HT) levels in brain is recognized in…”
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Dosimetry and whole body distribution of [F-18]PE2I in healthy volunteers by Lizana, Helena, Johansson, L., Larsson, A., Axelsson, Jan, Linder, J., Ögren, M., Varrone, A., Halldin, C., Jakobson Mo, Susanna

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Abstract # 1847 Cross-sectional and longitudinal associations between immune cells in blood and brain – A TSPO PET study in healthy control subjects by Kanegawa, N, Collste, K, Forsberg, A, Schain, M, Arakawa, R, Jucaite, A, Lekander, M, Höglund, C. Olgart, Kosek, E, Lampa, J, Halldin, C, Farde, L, Varrone, A, Cervenka, S

“…The interaction between immune cells in the periphery and brain in humans is poorly understood, partly due to the lack of in vivo studies. Here, we examined 32…”
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EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues by Vander Borght, T, Asenbaum, S, Bartenstein, P, Halldin, C, Kapucu, O, Van Laere, K, Varrone, A, Tatsch, K

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Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity by Nag, S., Kettschau, G., Heinrich, T., Varrone, A., Lehmann, L., Gulyas, B., Thiele, A., Keller, É., Halldin, C.

“…(S)-1-[18F]fluoro-N,4-dimethyl-N-(prop-2-ynyl)pentan-2-amine a new fluorine-18 labelled radioligands for detection of MAO-B activity by PET. The aim of this…”
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145. Translocator protein (TSPO) as a biomarker of microglia activation: PET imaging using [11C]PBR28 in Parkinson’s disease by Jucaite, A, Cselényi, Z, Varrone, A, Varnäs, K, Johnström, P, Halldin, C, Salter, H, McLoughlin, M.J, Rinne, J, Svenningsson, P, Alexander, R, Kugler, A, Farde, L

“…Positron emission tomography (PET) studies in Parkinson’s’ disease (PD) using the radioligand [11C]PK11195 have demonstrated increased binding to TSPO, in…”
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Safety and efficacy of recombinant human platelet derived growth factor (Rhpdgf) in Parkinson's disease by Paul, G, Zachrisson, O, Varrone, A, Almqvist, P, Jerling, M, Lindh, G, Rehncrona, S, Linderoth, B, Bjartmarz, H, Svensson, M, Mercer, K. Jansson, Forsberg, A, Shafer, L.L, Lang, A.M. Janson, Halldin, C, Svenningsson, P, Widner, H, Frisen, J, Pålhagen, S, Haegerstrand, A

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Synthesis of three F-18 labeled analogues ofl-deprenyl for PET studies of monoamine oxidase B by Nag, S., Lehmann, L., Kettschau, G., Heinrich, T., Brumby, T., Thiele, A., Varrone, A., Gulyas, B., Halldin, C.

“…Monoamine oxidases are important enzymes regulating the levels of monoaminergic neurotransmitters and of bioactive monoamines by catalyzing their deamination…”
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Confirmation of fenfluramine effect on 5-HT1B binding of [11C]AZ10419369 using an equilibrium approach by Finnema, S.J., Varrone, A., Hwang, T.J., Farde, L., Halldin, C.

“…Introduction: We previously reported an initial PET-study evaluating the effect of (±)-fenfluramine-induced serotonin release on the binding of the selective…”
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Synthesis of three F-18 labeled analogues of l-deprenyl for PET studies of monoamine oxidase B by Nag, S., Lehmann, L., Kettschau, G., Heinrich, T., Brumby, T., Thiele, A., Varrone, A., Gulyas, B., Halldin, C.

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