Search Results - "Varriano, Sophia"

Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells by Varriano, Sophia, Yu, Amy, Xu, Yu Qing, Natelson, Devorah M, Ramadei, Anthony, Kleiman, Frida E

“…The estrogen signalling pathway is highly dynamic and primarily mediated by estrogen receptors (ERs) that transcriptionally regulate the expression of target…”
Get full text

Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression by Baquero, Jorge, Varriano, Sophia, Ordonez, Martha, Kuczaj, Pawel, Murphy, Michael R, Aruggoda, Gamage, Lundine, Devon, Morozova, Viktoriya, Makki, Ali Elhadi, Alonso, Alejandra Del C, Kleiman, Frida E

“…While nuclear tau plays a role in DNA damage response (DDR) and chromosome relaxation, the mechanisms behind these functions are not fully understood. Here, we…”
Get full text

Treatment with novel topoisomerase inhibitors in Ewing sarcoma models reveals heterogeneity of tumor response by Lee, Unsun, Szabova, Ludmila, Collins, Victor J., Gordon, Melanie, Johnson, Kristine, Householder, Deborah, Jorgensen, Stephanie, Lu, Lucy, Bassel, Laura, Elloumi, Fathi, Peer, Cody J., Nelson, Ariana E., Varriano, Sophia, Varma, Sudhir, Roberts, Ryan D., Ohler, Zoe Weaver, Figg, William D., Sharan, Shyam K., Pommier, Yves, Heske, Christine M.

“…The topoisomerase 1 (TOP1) inhibitor irinotecan is a standard-of-care agent for relapsed Ewing sarcoma (EWS), but its efficacy is limited by chemical…”
Get full text

Long non-coding RNA generated from CDKN1A gene by alternative polyadenylation regulates p21 expression during DNA damage response by Murphy, Michael R, Ramadei, Anthony, Doymaz, Ahmet, Varriano, Sophia, Natelson, Devorah M, Yu, Amy, Aktas, Sera, Mazzeo, Marie, Mazzeo, Michael, Zakusilo, George, Kleiman, Frida E

“…Alternative Polyadenylation (APA) is an emerging mechanism for dynamic changes in gene expression. Previously, we described widespread APA occurrence in…”
Get full text

The Role of Estrogen Receptor Alpha in Regulating Messenger Rna 3' End Processing and Controlling Gene Expression in Breast Cancer Cells by Varriano, Sophia

“…Estrogen signaling regulates various physiological processes within the female reproductive, cardiovascular, immune, and central nervous systems and is…”
Get full text

mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response by Fonseca, Danae, Baquero, Jorge, Murphy, Michael R., Aruggoda, Gamage, Varriano, Sophia, Sapienza, Carmen, Mashadova, Oksana, Rahman, Shadaqur, Kleiman, Frida E.

“…The cellular response to DNA damage is an intricate mechanism that involves the interplay among several pathways. In this study, we provide evidence of the…”
Get full text

Epigenome-wide study identifies epigenetic outliers in normal mucosa of colorectal cancer patients by Ghosh, Jayashri, Schultz, Bryant M., Chan, Joe, Wultsch, Claudia, Singh, Rajveer, Shureiqi, Imad, Chow, Stephanie, Doymaz, Ahmet, Varriano, Sophia, Driscoll, Melissa, Muse, Jennifer, Kleiman, Frida E., Krampis, Konstantinos, Issa, Jean-Pierre J., Sapienza, Carmen

“…Non-genetic predisposition to colorectal cancer (CRC) continues to be difficult to measure precisely, hampering efforts in targeted prevention and screening…”
Get full text

Epigenome-Wide Study Identifies Epigenetic Outliers in Normal Mucosa of Patients with Colorectal Cancer by Ghosh, Jayashri, Schultz, Bryant M, Chan, Joe, Wultsch, Claudia, Singh, Rajveer, Shureiqi, Imad, Chow, Stephanie, Doymaz, Ahmet, Varriano, Sophia, Driscoll, Melissa, Muse, Jennifer, Kleiman, Frida E, Krampis, Konstantinos, Issa, Jean-Pierre J, Sapienza, Carmen

“…Nongenetic predisposition to colorectal cancer continues to be difficult to measure precisely, hampering efforts in targeted prevention and screening…”
Get full text

Abstract 6265: Do epigenetic outliers impact racial disparities in colorectal cancer by Ghosh, Jayashri, Schultz, Bryant M., Chan, Joe, Wultsch, Claudia, Shureiqi, Imad, Chow, Stephanie, Doymaz, Ahmet, Varriano, Sophia, Driscoll, Melissa, Muse, Jen, Kleiman, Frida E., Krampis, Konstantinos, Issa, Jean-Pierre J., Sapienza, Carmen

“…African Americans (AA) have a higher incidence and mortality rate for colorectal cancer (CRC) compared to Caucasians. DNA methylation profiling on normal colon…”
Get full text

Na+/H+ exchanger 1 (NHE1) function is necessary for maintaining mammary tissue architecture by Jenkins, Edmund C., Debnath, Shawon, Varriano, Sophia, Gundry, Stephen, Fata, Jimmie E.

“…Background: The mammary gland is an ideal model to study the link between form and function in normal tissue. Perhaps as interesting as the cues necessary to…”
Get full text