Perinatal maternal exposure to picrotoxin: Effects on sexual behavior in female rat offspring

Perinatal maternal exposure to picrotoxin: Effects on sexual behavior in female rat offspring

A previous study in our laboratory showed that perinatal maternal picrotoxin exposure (0.75 mg/kg) in rats improved heterosexual behavior in male offspring. In the present study, we examined the effects of this maternal treatment on sexual behavior in the female offspring. The dams received 0.75 mg/...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacology, biochemistry and behavior Vol. 81; no. 4; pp. 935 - 942
Main Authors: Teodorov, E., Moraes, A.P., Felicio, L.F., Varolli, F.M., Bernardi, M.M.
Format: Journal Article
Language:English
Published: New York, NY Elsevier Inc 01-08-2005
Elsevier Science
Subjects:
Animals
Animals, Newborn
Behavioral psychophysiology
Biological and medical sciences
Dopamine
Female
Fertility
Fundamental and applied biological sciences. Psychology
GABA
GABA Antagonists - pharmacology
Lactation
Male
Neurotransmission and behavior
Ovariectomy
Perinatal toxicology
Picrotoxin - pharmacology
Posture
Pregnancy
Prenatal Exposure Delayed Effects
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Wistar
Reproductive behavior
Sex Factors
Sexual Behavior, Animal - drug effects
Sexual development
Stress
Time Factors
Reproductive behavior
Sexual development
Dopamine
Perinatal toxicology
Fertility
GABA
Stress
CNS stimulant
Psychotropic
Sexual behavior
Perinatal
Exposure
Catecholamine
Gabaergic receptor
Progeny
Newborn animal
Neurotransmitter
Female
Gabaergic antagonist
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A previous study in our laboratory showed that perinatal maternal picrotoxin exposure (0.75 mg/kg) in rats improved heterosexual behavior in male offspring. In the present study, we examined the effects of this maternal treatment on sexual behavior in the female offspring. The dams received 0.75 mg/kg picrotoxin treatment (PT) once a day on the 18th and 21th day of pregnancy, 2 h after parturition and once a day during the first 4 days of lactation. The results showed that (1) at birth, the body weight and anogenital distance were not modified by treatment; (2) female sexual behavior was improved in experimental animals. These results demonstrate that perinatal picrotoxin exposure improves adult sexual behavior in female rat offspring as suggested by increase in the lordosis quotient.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2005.07.002