Search Results - "Varnum, Michael D"

Defective trafficking of cone photoreceptor CNG channels induces the unfolded protein response and ER-stress-associated cell death by Duricka, Deborah L, Brown, R Lane, Varnum, Michael D

“…Mutations that perturb the function of photoreceptor CNG (cyclic nucleotide-gated) channels are associated with several human retinal disorders, but the…”
Get more information

Dynamic functional and structural remodeling during retinal regeneration in zebrafish by Barrett, Lindsey M, Mitchell, Diana M, Meighan, Peter C, Varnum, Michael D, Stenkamp, Deborah L

“…Zebrafish regenerate their retinas following damage, resulting in restoration of visual function. Here we evaluate recovery of retinal function through…”
Get full text

Subunit Configuration of Heteromeric Cone Cyclic Nucleotide-Gated Channels by Peng, Changhong, Rich, Elizabeth D, Varnum, Michael D

“…Cone photoreceptor cyclic nucleotide-gated (CNG) channels are thought to be tetrameric assemblies of CNGB3 (B3) and CNGA3 (A3) subunits. We have used…”
Get full text

Interplay between PIP₃ and Calmodulin Regulation of Olfactory Cyclic Nucleotide-Gated Channels by Brady, James D., Rich, Elizabeth D., Martens, Jeffrey R., Karpen, Jeffrey W., Varnum, Michael D., Brown, R. Lane

“…Phosphatidylinositol-3,4,5-trisphosphate (PIP₃) has been proposed to modulate the odorant sensitivity of olfactory sensory neurons by inhibiting activation of…”
Get full text

Potentiation of CNG channel gating by matrix metalloproteinases is governed by the turret region and intracellular disulfide bonds by Biencourt, Sophie I., Meighan, Peter, Donlic, Kemal, Varnum, Michael D.

Get full text

Regulation of human cone cyclic nucleotide-gated channels by endogenous phospholipids and exogenously applied phosphatidylinositol 3,4,5-trisphosphate by Bright, Scott R, Rich, Elizabeth D, Varnum, Michael D

“…Cyclic nucleotide-gated (CNG) channels are critical components of the vertebrate visual transduction cascade involved in converting light-induced changes in…”
Get more information

Functional consequences of progressive cone dystrophy-associated mutations in the human cone photoreceptor cyclic nucleotide-gated channel CNGA3 subunit by Liu, Chunming, Varnum, Michael D

“…Progressive cone dystrophies are a genetically heterogeneous group of disorders characterized by early deterioration of visual acuity and color vision,…”
Get more information

Achromatopsia-associated Mutation in the Human Cone Photoreceptor Cyclic Nucleotide-gated Channel CNGB3 Subunit Alters the Ligand Sensitivity and Pore Properties of Heteromeric Channels by Peng, Changhong, Rich, Elizabeth D., Varnum, Michael D.

“…Cone photoreceptor cyclic nucleotide-gated (CNG) channels are thought to form by assembly of two different subunit types, CNGA3 and CNGB3. Recently, mutations…”
Get full text

Assessing Rewiring of the Retinal Circuitry by Electroretinogram (ERG) After Inner Retinal Lesion in Adult Zebrafish by Barrett, Lindsey M, Meighan, Peter C, Mitchell, Diana M, Varnum, Michael D, Stenkamp, Deborah L

“…Adult zebrafish respond to retinal injury with a regenerative response that replaces damaged neurons with Müller glia-derived regenerated neurons. The…”
Get more information

CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactions by Dai, Gucan, Varnum, Michael D

“…Cyclic nucleotide-gated (CNG) channels are critical for sensory transduction in retinal photoreceptors and olfactory receptor cells; their activity is…”
Get more information

Matrix metalloproteinase-9 and -2 enhance the ligand sensitivity of photoreceptor cyclic nucleotide-gated channels by Meighan, Peter C., Meighan, Starla E., Rich, Elizabeth D., Brown, R. Lane, Varnum, Michael D.

“…Photoreceptor cyclic nucleotide-gated (CNG) channels are the principal ion channels responsible for transduction of the light-induced change in cGMP…”
Get full text

Restoration of Dendritic Complexity, Functional Connectivity, and Diversity of Regenerated Retinal Bipolar Neurons in Adult Zebrafish by McGinn, Timothy E, Mitchell, Diana M, Meighan, Peter C, Partington, Natalie, Leoni, Dylan C, Jenkins, Christina E, Varnum, Michael D, Stenkamp, Deborah L

“…Adult zebrafish ( ) are capable of regenerating retinal neurons that have been lost due to mechanical, chemical, or light damage. In the case of chemical…”
Get full text

Functionally Important Calmodulin-binding Sites in Both NH2- and COOH-terminal Regions of the Cone Photoreceptor Cyclic Nucleotide-gated Channel CNGB3 Subunit by Peng, Changhong, Rich, Elizabeth D, Thor, Christopher A, Varnum, Michael D

“…Whereas an important aspect of sensory adaptation in rod photoreceptors and olfactory receptor neurons is thought to be the regulation of cyclic…”
Get full text

Alternative Splicing Governs Cone Cyclic Nucleotide-gated (CNG) Channel Sensitivity to Regulation by Phosphoinositides by Dai, Gucan, Sherpa, Tshering, Varnum, Michael D.

“…Precursor mRNA encoding CNGA3 subunits of cone photoreceptor cyclic nucleotide-gated (CNG) channels undergoes alternative splicing, generating isoforms…”
Get full text

Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides by Dai, Gucan, Peng, Changhong, Liu, Chunming, Varnum, Michael D

“…Cyclic nucleotide-gated (CNG) channels in retinal photoreceptors play a crucial role in vertebrate phototransduction. The ligand sensitivity of photoreceptor…”
Get full text

Disease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells by Liu, Chunming, Sherpa, Tshering, Varnum, Michael D

“…To determine if achromatopsia associated F525N and T383fsX mutations in the CNGB3 subunit of cone photoreceptor cyclic nucleotide-gated (CNG) channels…”
Get full text

Inherited macular degeneration-associated mutations in CNGB3 increase the ligand sensitivity and spontaneous open probability of cone cyclic nucleotide-gated channels by Meighan, Peter C, Peng, Changhong, Varnum, Michael D

“…Cyclic nucleotide gated (CNG) channels are a critical component of the visual transduction cascade in the vertebrate retina. Mutations in the genes encoding…”
Get full text

Cyclic Nucleotide-Gated Channel Subunit Glycosylation Regulates Matrix Metalloproteinase-Dependent Changes in Channel Gating by Meighan, Starla E, Meighan, Peter C, Rich, Elizabeth D, Brown, R. Lane, Varnum, Michael D

“…Cyclic-nucleotide gated (CNG) channels are essential for phototransduction within retinal photoreceptors. We have demonstrated previously that the enzymatic…”
Get full text

Disruption of an Intersubunit Interaction Underlies Ca2+-Calmodulin Modulation of Cyclic Nucleotide-Gated Channels by Zheng, Jie, Varnum, Michael D, Zagotta, William N

“…Cyclic nucleotide-gated channels are key molecular elements for olfactory transduction. Olfactory adaptation caused by repeated exposure to an odorant has been…”
Get full text

Interdomain Interactions Underlying Activation of Cyclic Nucleotide-Gated Channels by Varnum, Michael D., Zagotta, William N.

“…Cyclic nucleotide-gated (CNG) ion channels are multimeric proteins that activate in response to the binding of cyclic nucleotide to intracellular domains…”
Get full text