Search Results - "Varnum, Megan"

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain by Varnum, Megan M., Ikezu, Tsuneya

“…Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive decline of cognitive function. There is no therapy that can halt or…”
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The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease by Varnum, Megan M, Kiyota, Tomomi, Ingraham, Kaitlin L, Ikezu, Seiko, Ikezu, Tsuneya

“…Abstract Cluster of Differentiation-200 (CD200) is an anti-inflammatory glycoprotein expressed in neurons, T cells, and B cells, and its receptor is expressed…”
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A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells by Varnum, Megan M., Clayton, Kevin A., Yoshii-Kitahara, Asuka, Yonemoto, Grant, Koro, Lacin, Ikezu, Seiko, Ikezu, Tsuneya

“…Triggering receptor expressed on myeloid cells 2 (TREM2) is a single transmembrane molecule uniquely expressed in microglia. TREM2 mutations are genetically…”
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Effects of blocking developmental cell death on sexually dimorphic calbindin cell groups in the preoptic area and bed nucleus of the stria terminalis by Gilmore, Richard F, Varnum, Megan M, Forger, Nancy G

“…Calbindin-D28 has been used as a marker for the sexually dimorphic nucleus of the preoptic area (SDN-POA). Males have a distinct cluster of…”
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Prevention of bleomycin‐induced lung fibrosis via inhibition of the MRTF/SRF transcription pathway by Pawelec, Kendell M., Varnum, Megan, Harkema, Jack R., Auerbach, Bruce, Larsen, Scott D., Neubig, Richard R.

“…Bleomycin‐induced lung fibrosis is a debilitating disease, linked to high morbidity and mortality in chemotherapy patients. The MRTF/SRF transcription pathway…”
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Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies by Vanderweyde, Tara, Yu, Haung, Varnum, Megan, Liu-Yesucevitz, Liqun, Citro, Allison, Ikezu, Tsuneya, Duff, Karen, Wolozin, Benjamin

“…Stress induces aggregation of RNA-binding proteins to form inclusions, termed stress granules (SGs). Recent evidence suggests that SG proteins also colocalize…”
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Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice by Shahani, Neelam, Huang, Wen-Chin, Varnum, Megan, Page, Damon T., Subramaniam, Srinivasa

“…The precise molecular and cellular events responsible for age-dependent cognitive dysfunctions remain unclear. We report that Rheb (ras homolog enriched in…”
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Forebrain Depletion of Rheb Elicits Spatial Memory Deficits in Mice by Shahani, Neelam, Huang, Wen-Chin, Varnum, Megan, Page, Damon T, Subramaniam, Srinivasa

“…Abstract The precise molecular and cellular events responsible for age-dependent cognitive dysfunctions remain unclear. We report that small guanine…”
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O4‐04‐01: Microglial Exosomes Propagate Tau Protein from the Entorhinal Cortex to the Hippocampus: An Early Pathophysiology of Alzheimer's Disease by Ikezu, Tsuneya, Ikezu, Seiko, Varnum, Megan, Wolozin, Benjamin, Butovsky, Oleg, Kügler, Sebastian, Medalla, Maria, Luebke, Jennfier, Haydar, Tarik F.

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AAV2/1‐mediated gene delivery of CD200 into the hippocampus enhances neurogenesis and amyloid clearance in the APP mouse by Varnum, Megan M, Kiyota, Tomomi, Ingraham, Kaitlin, Ikezu, Seiko, Ikezu, Tsuneya

“…Abstract only Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive decline of cognitive function and memory formation…”
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MICROGLIAL EXOSOMES PROPAGATE TAU PROTEIN FROM THE ENTORHINAL CORTEX TO THE HIPPOCAMPUS: AN EARLY PATHOPHYSIOLOGY OF ALZHEIMER’S DISEASE by Ikezu, Tsuneya, Ikezu, Seiko, Varnum, Megan, Wolozin, Benjamin, Butovsky, Oleg, Kügler, Sebastian, Medalla, Maria, Luebke, Jennfier, Haydar, Tarik F

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P4‐040: Phosphorylation of collapsin response mediator protein‐2 and axonal degeneration in transgenic mice expressing a familial Alzheimer's disease mutant of APP and tau‐tubulin kinase 1 by Asai, Hirohide, Ikezu, Seiko, Varnum, Megan, Ikezu, Tsuneya

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Phosphorylation of collapsin response mediator protein-2 and axonal degeneration in transgenic mice expressing a familial Alzheimer's disease mutant of APP and tau-tubulin kinase 1 by Asai, Hirohide, Ikezu, Seiko, Varnum, Megan, Ikezu, Tsuneya

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P2‐144: Accelerated neurodegeneration and phenotypic switch of neuroinflammation in transgenic mice expressing P301L tau‐mutant and tau‐tubulin kinase 1 by Asai, Hirohide, Woodbury, Maya, Ikezu, Seiko, Varnum, Megan, Ikezu, Tsuneya

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Accelerated neurodegeneration and phenotypic switch of neuroinflammation in transgenic mice expressing P301L tau-mutant and tau-tubulin kinase 1 by Asai, Hirohide, Woodbury, Maya, Ikezu, Seiko, Varnum, Megan, Ikezu, Tsuneya

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Effects of Neonatal Treatment with Valproic Acid on Vasopressin Immunoreactivity and Olfactory Behaviour in Mice by Murray, E. K., Varnum, M. M., Fernandez, J. L., de Vries, G. J., Forger, N. G.

“…Recent findings demonstrate that epigenetic modifications are required for the sexual differentiation of the brain. For example, neonatal administration of the…”
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An anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease by Varnum, Megan Marissa

“…Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β peptide (Aβ) in the brain and intraneuronal…”
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