Search Results - "Varney, Scott"

Integrin α4β1 is required for IL‐1α‐ and Nrf2‐dependent, Cox‐2 induction in fibroblasts, supporting a mechanism that suppresses α‐SMA expression by Zheng, Rui, Varney, Scott D., Wu, Lei, DiPersio, C. Michael, Van De Water, Livingston

“…Growth and repair processes, both normal and pathological, require reciprocal interactions between cells and their microenvironment. Integrins are…”
Get full text

Loss of Integrin α9β1 on Tumor Keratinocytes Enhances the Stromal Vasculature and Growth of Cutaneous Tumors by Varney, Scott D., Wu, Lei, Longmate, Whitney M., DiPersio, C. Michael, Van De Water, Livingston

“…Angiogenesis is critical to tumor progression, and the function of integrins in tumor angiogenesis is complex. In this study, we report that loss of integrin…”
Get full text

Hic-5 is required for myofibroblast differentiation by regulating mechanically dependent MRTF-A nuclear accumulation by Varney, Scott D, Betts, Courtney B, Zheng, Rui, Wu, Lei, Hinz, Boris, Zhou, Jiliang, Van De Water, Livingston

“…How mechanical cues from the extracellular environment are translated biochemically to modulate the effects of TGF-β on myofibroblast differentiation remains a…”
Get full text

Regulation of myoepithelial differentiation by Thiemann, Renee F, Varney, Scott, Moskwa, Nicholas, Lamar, John, Larsen, Melinda, LaFlamme, Susan E

“…The salivary gland can be permanently impaired by radiation treatment for head and neck cancers. Efforts at tissue regeneration have focused on…”
Get full text

Matrix compliance and the regulation of cytokinesis by Sambandamoorthy, Savitha, Mathew-Steiner, Shomita, Varney, Scott, Zuidema, Jonathan M, Gilbert, Ryan J, Van De Water, Livingston, LaFlamme, Susan E

“…Integrin-mediated cell adhesion to the ECM regulates many physiological processes in part by controlling cell proliferation. It is well established that many…”
Get full text

Keratinocyte Integrin α3β1 Promotes Secretion of IL-1α to Effect Paracrine Regulation of Fibroblast Gene Expression and Differentiation by Zheng, Rui, Longmate, Whitney M., DeFreest, Lori, Varney, Scott, Wu, Lei, DiPersio, C. Michael, Van De Water, Livingston

“…After cutaneous injury, keratinocytes secrete paracrine factors that regulate wound cell functions; dysregulation of this signaling can lead to wound…”
Get full text

Integrin α3β1 on Tumor Keratinocytes Is Essential to Maintain Tumor Growth and Promotes a Tumor-Supportive Keratinocyte Secretome by Longmate, Whitney M., Varney, Scott, Power, Derek, Miskin, Rakshitha Pandulal, Anderson, Karl E., DeFreest, Lori, Van De Water, Livingston, DiPersio, C. Michael

“…The development of integrin-targeted cancer therapies is hindered by incomplete understanding of integrin function in tumor cells and the tumor…”
Get full text

Serological analysis reveals an imbalanced IgG subclass composition associated with COVID-19 disease severity by Yates, Jennifer L., Ehrbar, Dylan J., Hunt, Danielle T., Girardin, Roxanne C., Dupuis, Alan P., Payne, Anne F., Sowizral, Mycroft, Varney, Scott, Kulas, Karen E., Demarest, Valerie L., Howard, Kelly M., Carson, Kyle, Hales, Margaux, Ejemel, Monir, Li, Qi, Wang, Yang, Peredo-Wende, Ruben, Ramani, Ananthakrishnan, Singh, Gurpreet, Strle, Klemen, Mantis, Nicholas J., McDonough, Kathleen A., Lee, William T.

“…Coronavirus disease 2019 (COVID-19) is associated with a wide spectrum of disease presentation, ranging from asymptomatic infection to acute respiratory…”
Get full text

The TGFβ1I1 locus is required for myofibroblast differentiation by potentiating TGF-β-dependent mechanotransduction by Varney, Scott

“…Fibrosis contributes to nearly half of all deaths in the industrialized world. The major cell type underpinning fibrotic disease is the highly contractile…”
Get full text