Search Results - "Varner, Victor D."

Cellular and physical mechanisms of branching morphogenesis by Varner, Victor D, Nelson, Celeste M

“…Branching morphogenesis is the developmental program that builds the ramified epithelial trees of various organs, including the airways of the lung, the…”
Get full text

Localized Smooth Muscle Differentiation Is Essential for Epithelial Bifurcation during Branching Morphogenesis of the Mammalian Lung by Kim, Hye Young, Pang, Mei-Fong, Varner, Victor D., Kojima, Lisa, Miller, Erin, Radisky, Derek C., Nelson, Celeste M.

“…The airway epithelium develops into a tree-like structure via branching morphogenesis. Here, we show a critical role for localized differentiation of airway…”
Get full text

Mechanically patterning the embryonic airway epithelium by Varner, Victor D., Gleghorn, Jason P., Miller, Erin, Radisky, Derek C., Nelson, Celeste M.

“…Collections of cells must be patterned spatially during embryonic development to generate the intricate architectures of mature tissues. In several cases,…”
Get full text

Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung by Kim, Hye Young, Varner, Victor D, Nelson, Celeste M

“…Branching morphogenesis sculpts the airway epithelium of the lung into a tree-like structure to conduct air and promote gas exchange after birth. In the avian…”
Get full text

Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices by Gjorevski, Nikolce, S. Piotrowski, Alexandra, Varner, Victor D., Nelson, Celeste M.

“…Collective cell migration drives tissue remodeling during development, wound repair and metastatic invasion. The physical mechanisms by which cells move…”
Get full text

Computational models of airway branching morphogenesis by Varner, Victor D., Nelson, Celeste M.

“…The bronchial network of the mammalian lung consists of millions of dichotomous branches arranged in a highly complex, space-filling tree. Recent computational…”
Get full text

Mechanics of head fold formation: investigating tissue-level forces during early development by Varner, Victor D, Voronov, Dmitry A, Taber, Larry A

“…During its earliest stages, the avian embryo is approximately planar. Through a complex series of folds, this flat geometry is transformed into the intricate…”
Get full text

Computational models for mechanics of morphogenesis by Wyczalkowski, Matthew A., Chen, Zi, Filas, Benjamen A., Varner, Victor D., Taber, Larry A.

“…In the developing embryo, tissues differentiate, deform, and move in an orchestrated manner to generate various biological shapes driven by the complex…”
Get full text

A Meta-Analysis of Intracortical Device Stiffness and Its Correlation with Histological Outcomes by Stiller, Allison M, Black, Bryan J, Kung, Christopher, Ashok, Aashika, Cogan, Stuart F, Varner, Victor D, Pancrazio, Joseph J

“…Neural implants offer solutions for a variety of clinical issues. While commercially available devices can record neural signals for short time periods, they…”
Get full text

Focal sources of FGF-10 promote the buckling morphogenesis of the embryonic airway epithelium by Peak, Kara E, Mohr-Allen, Shelby R, Gleghorn, Jason P, Varner, Victor D

“…During airway branching morphogenesis, focal regions of FGF-10 expression in the pulmonary mesenchyme are thought to provide a local guidance cue, which…”
Get full text

Signaling Downstream of Focal Adhesions Regulates Stiffness-Dependent Differences in the TGF-β1-Mediated Myofibroblast Differentiation of Corneal Keratocytes by Maruri, Daniel P., Iyer, Krithika S., Schmidtke, David W., Petroll, W. Matthew, Varner, Victor D.

“…Following injury and refractive surgery, corneal wound healing can initiate a protracted fibrotic response that interferes with ocular function. This fibrosis…”
Get full text

Anisotropic, porous hydrogels templated by lyotropic chromonic liquid crystals by Wang, Suitu, Maruri, Daniel P, Boothby, Jennifer M, Lu, Xili, Rivera-Tarazona, Laura K, Varner, Victor D, Ware, Taylor H

“…Approaches to control the microstructure of hydrogels enable the control of cell-material interactions and the design of stimuli-responsive materials. We…”
Get more information

Effects of Topography and PDGF on the Response of Corneal Keratocytes to Fibronectin-Coated Surfaces by Lam, Kevin H, Shihabeddin, Tarik Z, Awkal, Jacob A, Najjar, Alex M, Miron-Mendoza, Miguel, Maruri, Daniel P, Varner, Victor D, Petroll, W Matthew, Schmidtke, David W

“…During corneal wound healing, corneal keratocytes are exposed to both biophysical and soluble cues that cause them to transform from a quiescent state to a…”
Get full text

An In Vitro Model for Assessing Corneal Keratocyte Spreading and Migration on Aligned Fibrillar Collagen by Kivanany, Pouriska B, Grose, Kyle C, Yonet-Tanyeri, Nihan, Manohar, Sujal, Sunkara, Yukta, Lam, Kevin H, Schmidtke, David W, Varner, Victor D, Petroll, W Matthew

“…Corneal stromal cells (keratocytes) are responsible for developing and maintaining normal corneal structure and transparency, and for repairing the tissue…”
Get full text

Toward Measuring the Mechanical Stresses Exerted by Branching Embryonic Airway Epithelial Explants in 3D Matrices of Matrigel by Patil, Lokesh S., Varner, Victor D.

“…Numerous organs in the bodies of animals, including the lung, kidney, and mammary gland, contain ramified networks of epithelial tubes. These structures arise…”
Get full text

Microfluidic chest cavities reveal that transmural pressure controls the rate of lung development by Nelson, Celeste M, Gleghorn, Jason P, Pang, Mei-Fong, Jaslove, Jacob M, Goodwin, Katharine, Varner, Victor D, Miller, Erin, Radisky, Derek C, Stone, Howard A

“…Mechanical forces are increasingly recognized to regulate morphogenesis, but how this is accomplished in the context of the multiple tissue types present…”
Get full text

Keratocyte mechanobiology by Petroll, W Matthew, Varner, Victor D, Schmidtke, David W

“…In vivo, corneal keratocytes reside within a complex 3D extracellular matrix (ECM) consisting of highly aligned collagen lamellae, growth factors, and other…”
Get full text

Insertion mechanics of amorphous SiC ultra-micro scale neural probes by Geramifard, Negar, Dousti, Behnoush, Nguyen, Christopher, Abbott, Justin, Cogan, Stuart F, Varner, Victor D

“… Trauma induced by the insertion of microelectrodes into cortical neural tissue is a significant problem. Further, micromotion and mechanical mismatch between…”
Get more information

Not just inductive: a crucial mechanical role for the endoderm during heart tube assembly by Varner, Victor D, Taber, Larry A

“…The heart is the first functioning organ to form during development. During gastrulation, the cardiac progenitors reside in the lateral plate mesoderm but…”
Get full text

ECM Stiffness Controls the Activation and Contractility of Corneal Keratocytes in Response to TGF-β1 by Maruri, Daniel P., Miron-Mendoza, Miguel, Kivanany, Pouriska B., Hack, Joshua M., Schmidtke, David W., Petroll, W. Matthew, Varner, Victor D.

“…After surgery or traumatic injury, corneal wound healing can cause a scarring response that stiffens the tissue and impairs ocular function. This fibrosis is…”
Get full text