Search Results - "Varnäs, K."

Altered Serotonin 1B Receptor Binding After Escitalopram for Depression Is Correlated With Treatment Effect by Gärde, M, Matheson, G J, Varnäs, K, Svenningsson, P, Hedman-Lagerlöf, E, Lundberg, J, Farde, L, Tiger, M

“…Major depressive disorder (MDD) is commonly treated with selective serotonin reuptake inhibitors (SSRIs). SSRIs inhibit the serotonin transporter (5-HTT), but…”
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Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [11C]AZ10419369 Positron Emission Tomography Study by Tangen, Ämma, Veldman, Emma R, Svensson, Jonas, Tiger, Mikael, Nord, Magdalena, Sorjonen, Kimmo, Andersson, Max, Plavén-Sigray, Pontus, Varrone, Andrea, Halldin, Christer, Varnäs, Katarina, Borg, Jacqueline, Lundberg, Johan

“…Abstract Background The serotonin system has been implicated in several psychiatric disorders. All major psychiatric disorders are associated with cognitive…”
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Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676 by Varnäs, Katarina, Juréus, Anders, Johnström, Peter, Ahlgren, Charlotte, Schött, Pär, Schou, Magnus, Gruber, Susanne, Jerning, Eva, Malmborg, Jonas, Halldin, Christer, Afzelius, Lovisa, Farde, Lars

“…Positron emission tomography (PET) is widely applied in central nervous system (CNS) drug development for assessment of target engagement in vivo. As the…”
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P.1.g.069 Relationship between dose, plasma concentration and GABA-A receptor occupancy by partial GABA-A receptor modulators by Jucaite, A, Lappalainen, J, Cselenyi, Z, Varnäs, K, Stenkrona, P, Halldin, C, Cross, A, Farde, L

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Amphetamine decreases binding of the novel alpha2C-adrenoreceptor radioligand [11C]ORM-13070 in monkey brain by Finnema, S.J., Varnäs, K., Stepanov, V., Varrone, A., Gulyás, B., Arponen, E., Helin, S., Solin, O., Haaparanta, M., Sallinen, J., Ingman, K., Scheinin, M., Farde, L., Halldin, C.

“…Initial characterization of [11C]ORM-13070 has been performed in rat and human and has indicated that [11C]ORM-13070 binds selectively to the…”
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145. Translocator protein (TSPO) as a biomarker of microglia activation: PET imaging using [11C]PBR28 in Parkinson’s disease by Jucaite, A, Cselényi, Z, Varrone, A, Varnäs, K, Johnström, P, Halldin, C, Salter, H, McLoughlin, M.J, Rinne, J, Svenningsson, P, Alexander, R, Kugler, A, Farde, L

“…Positron emission tomography (PET) studies in Parkinson’s’ disease (PD) using the radioligand [11C]PK11195 have demonstrated increased binding to TSPO, in…”
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11 Early clinical development of amyloid-beta specific PET radioligand [18F]AZD4694 by Cselényi, Zsolt, Forsberg, A, Halldin, C, Schou, M, Johnström, P, Varnäs, K, Svensson, S, Andreasen, N, Reiman, E.M, Eriksdotter-Jönhagen, M, Farde, L

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Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: Validation using postmortem autoradiography data by Fazio, P., Schain, M., Varnäs, K., Halldin, C., Farde, L., Varrone, A.

“…The human brainstem is a complex structure with several small nuclei and neural pathways of interest in the pathophysiology of central nervous system (CNS)…”
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Synthesis and biological evaluation of technetium(III) mixed-ligand complexes with high affinity for the cerebral 5-HT1A receptor and the alpha1-adrenergic receptor by DREWS, A, PIETZSCH, H.-J, SPIES, H, JOHANNSEN, B, SYHRE, R, SEIFERT, S, VARNÄS, K, HALL, H, HALLDIN, C, KRAUS, W, KARLSSON, P, JOHNSSON, C

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Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain by Varnäs, Katarina, Halldin, Christer, Hall, Håkan

“…Several neurochemical in vitro and in vivo imaging studies have been aimed at characterizing the localization of serotonin receptors and transporters in the…”
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Associations between cognition and serotonin receptor 1B binding in patients with major depressive disorder – a pilot study by Tangen, Ämma, Borg, Jacqueline, Tiger, Mikael, Varnäs, Katarina, Sorjonen, Kimmo, Lindefors, Nils, Halldin, Christer, Lundberg, Johan

“…Highlights • Verbal fluency improved after Internet-based CBT in patients with MDD. • Significant correlations were found between cognitive ability and 5-HT1BR…”
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Synthesis, biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high affinity for the 5-HT1A receptor and the alpha1-adrenergic receptor by Heimbold, I., Drews, A., Kretzschmar, M., Varnäs, K., Hall, H., Halldin, C., Syhre, R., Kraus, W., Pietzsch, H.-J., Seifert, S., Brust, P., Johannsen, B.

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New halogenated [11c]WAY analogues, [11C]6FPWAY and [11c]6bpway-radiosynthesis and assessment as radioligands for the study of brain 5-HT1A receptors in living monkey by SANDELL, Johan, HALLDIN, Christer, FARDE, Lars, PIKE, Victor W, CHOU, Yuan-Hwa, VARNÄS, Katarina, HALL, Hakan, MARCHAIS, Sandrine, NOWICKI, Bartek, WIKSTRÖM, Hakan V, SWAHN, Carl-Gunnar

“…[Carbonyl-(11)C]WAY-100635 ([(11)C]WAY) is an established radioligand for the study of brain serotonin(1A) (5-HT(1A)) receptors in living animals and humans…”
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Synthesis, biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high affinity for the 5-HT 1A receptor and the alpha1-adrenergic receptor by Heimbold, I., Drews, A., Kretzschmar, M., Varnäs, K., Hall, H., Halldin, C., Syhre, R., Kraus, W., Pietzsch, H.-J., Seifert, S., Brust, P., Johannsen, B.

“…This paper reports the synthesis, biological evaluation, in vitro and ex vivo autoradiography of the first Tc-99m ligand with subnanomolar affinity for the…”
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The 5-HT 1B receptor - a potential target for antidepressant treatment by Tiger, Mikael, Varnäs, Katarina, Okubo, Yoshiro, Lundberg, Johan

“…Major depressive disorder (MDD) is the leading cause of disability worldwide. The serotonin hypothesis may be the model of MDD pathophysiology with the most…”
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Candidate genes and brain cortical morphology in schizophrenia by Agartz, I, Varnäs, K, Lawyer, G, Jönsson, E.G, Kulle, B, Nesvåg, R, Hall, H, Terenius, L, Saetre, P

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Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743 by Varnäs, K, Hall, H, Bonaventure, P, Sedvall, G

“…The distribution of 5-HT(1B) and 5-HT(1D) receptors in the human post mortem brain was examined using whole hemisphere autoradiography and the radioligand…”
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Autoradiographic mapping of synaptic vesicle glycoprotein 2A in non‐human primate and human brain by Varnäs, Katarina, Stepanov, Vladimir, Halldin, Christer

“…Synaptic vesicle glycoprotein 2A (SV2A) has been previously characterized as an imaging biomarker for assessment of synaptic density in positron emission…”
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The 5-HT1B receptor - a potential target for antidepressant treatment by Tiger, Mikael, Varnäs, Katarina, Okubo, Yoshiro, Lundberg, Johan

“…Major depressive disorder (MDD) is the leading cause of disability worldwide. The serotonin hypothesis may be the model of MDD pathophysiology with the most…”
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Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity by Ballard, Peter, Yates, James W T, Yang, Zhenfan, Kim, Dong-Wan, Yang, James Chih-Hsin, Cantarini, Mireille, Pickup, Kathryn, Jordan, Angela, Hickey, Mike, Grist, Matthew, Box, Matthew, Johnström, Peter, Varnäs, Katarina, Malmquist, Jonas, Thress, Kenneth S, Jänne, Pasi A, Cross, Darren

“…Approximately one-third of patients with non-small cell lung cancer (NSCLC) harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutations…”
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