Search Results - "Varley, Andrew J."

Chemical strategies for strand selection in short-interfering RNAs by Varley, Andrew J, Desaulniers, Jean-Paul

“…Therapeutic small interfering RNAs (siRNAs) are double stranded RNAs capable of potent and specific gene silencing through activation of the RNA interference…”
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Establishing a Role for Bacterial Cellulose in Environmental Interactions: Lessons Learned from Diverse Biofilm-Producing Proteobacteria by Augimeri, Richard V, Varley, Andrew J, Strap, Janice L

“…Bacterial cellulose (BC) serves as a molecular glue to facilitate intra- and inter-domain interactions in nature. Biosynthesis of BC-containing biofilms occurs…”
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Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs by Tsubaki, Kouta, Hammill, Matthew L, Varley, Andrew J, Kitamura, Mitsuru, Okauchi, Tatsuo, Desaulniers, Jean-Paul

“…Two unsymmetrical dinucleotide phosphate triesters were synthesized via transesterification from tris­(2,2,2-trifluoroethyl) phosphate. The protected triesters…”
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Building siRNAs with Cubes: Synthesis and Evaluation of Cubane‐Modified siRNAs by Hammill, Matthew L., Salim, Lidya, Tsubaki, Kouta, Varley, Andrew J., Kitamura, Mitsuru, Okauchi, Tatsuo, Desaulniers, Jean‐Paul

“…Cubane molecules hold great potential for medicinal chemistry applications due to their inherent stability and low toxicity. In this study, we report the…”
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SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity by Hammill, Matthew L, Tsubaki, Kouta, Salim, Lidya, Varley, Andrew J, Giorgees, Ifrodet, Kitamura, Mitsuru, Okauchi, Tatsuo, Desaulniers, Jean-Paul

“…Short interfering RNAs (siRNAs) show promise as gene-silencing therapeutics, but their cellular uptake remains a challenge. We have recently shown the…”
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Utilizing the Ethylene-releasing Compound, 2-Chloroethylphosphonic Acid, as a Tool to Study Ethylene Response in Bacteria by Augimeri, Richard V, Varley, Andrew J, Strap, Janice L

“…Ethylene (C2H4) is a gaseous phytohormone that is involved in numerous aspects of plant development, playing a dominant role in senescence and fruit ripening…”
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Utilizing the Ethylene-releasing Compound, 2-Chloroethylphosphonic Acid, as a Tool to Study Ethylene Response in Bacteria by Augimeri, Richard V., Varley, Andrew J., Strap, Janice L.

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