Search Results - "Varley, Andrew"

Clinical delivery of circular RNA: Lessons learned from RNA drug development by Loan Young, Tiana, Chang Wang, Kevin, James Varley, Andrew, Li, Bowen

“…[Display omitted] Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules, which play diverse roles in regulating biological…”
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Chemical strategies for strand selection in short-interfering RNAs by Varley, Andrew J, Desaulniers, Jean-Paul

“…Therapeutic small interfering RNAs (siRNAs) are double stranded RNAs capable of potent and specific gene silencing through activation of the RNA interference…”
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Establishing a Role for Bacterial Cellulose in Environmental Interactions: Lessons Learned from Diverse Biofilm-Producing Proteobacteria by Augimeri, Richard V, Varley, Andrew J, Strap, Janice L

“…Bacterial cellulose (BC) serves as a molecular glue to facilitate intra- and inter-domain interactions in nature. Biosynthesis of BC-containing biofilms occurs…”
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AGILE platform: a deep learning powered approach to accelerate LNP development for mRNA delivery by Xu, Yue, Ma, Shihao, Cui, Haotian, Chen, Jingan, Xu, Shufen, Gong, Fanglin, Golubovic, Alex, Zhou, Muye, Wang, Kevin Chang, Varley, Andrew, Lu, Rick Xing Ze, Wang, Bo, Li, Bowen

“…Ionizable lipid nanoparticles (LNPs) are seeing widespread use in mRNA delivery, notably in SARS-CoV-2 mRNA vaccines. However, the expansion of mRNA therapies…”
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Building siRNAs with Cubes: Synthesis and Evaluation of Cubane‐Modified siRNAs by Hammill, Matthew L., Salim, Lidya, Tsubaki, Kouta, Varley, Andrew J., Kitamura, Mitsuru, Okauchi, Tatsuo, Desaulniers, Jean‐Paul

“…Cubane molecules hold great potential for medicinal chemistry applications due to their inherent stability and low toxicity. In this study, we report the…”
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Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs by Tsubaki, Kouta, Hammill, Matthew L, Varley, Andrew J, Kitamura, Mitsuru, Okauchi, Tatsuo, Desaulniers, Jean-Paul

“…Two unsymmetrical dinucleotide phosphate triesters were synthesized via transesterification from tris­(2,2,2-trifluoroethyl) phosphate. The protected triesters…”
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SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity by Hammill, Matthew L, Tsubaki, Kouta, Salim, Lidya, Varley, Andrew J, Giorgees, Ifrodet, Kitamura, Mitsuru, Okauchi, Tatsuo, Desaulniers, Jean-Paul

“…Short interfering RNAs (siRNAs) show promise as gene-silencing therapeutics, but their cellular uptake remains a challenge. We have recently shown the…”
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FlyMine: an integrated database for Drosophila and Anopheles genomics by Lyne, Rachel, Smith, Richard, Rutherford, Kim, Wakeling, Matthew, Varley, Andrew, Guillier, Francois, Janssens, Hilde, Ji, Wenyan, Mclaren, Peter, North, Philip, Rana, Debashis, Riley, Tom, Sullivan, Julie, Watkins, Xavier, Woodbridge, Mark, Lilley, Kathryn, Russell, Steve, Ashburner, Michael, Mizuguchi, Kenji, Micklem, Gos

“…FlyMine is a data warehouse that addresses one of the important challenges of modern biology: how to integrate and make use of the diversity and volume of…”
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Utilizing the Ethylene-releasing Compound, 2-Chloroethylphosphonic Acid, as a Tool to Study Ethylene Response in Bacteria by Augimeri, Richard V, Varley, Andrew J, Strap, Janice L

“…Ethylene (C2H4) is a gaseous phytohormone that is involved in numerous aspects of plant development, playing a dominant role in senescence and fruit ripening…”
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Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing by Li, Bowen, Manan, Rajith Singh, Liang, Shun-Qing, Gordon, Akiva, Jiang, Allen, Varley, Andrew, Gao, Guangping, Langer, Robert, Xue, Wen, Anderson, Daniel

“…The expanding applications of nonviral genomic medicines in the lung remain restricted by delivery challenges. Here, leveraging a high-throughput platform, we…”
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Synthesis of 5'-fluorophosphate-modified short-interfering RNAs by Varley, Andrew, Desaulniers, Jean-Paul

“…We have developed an improved scheme for the synthesis of a mono-fluorinated phosphoramidite for the 5'-modification of nucleic acids using standard…”
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Tumor‐Tailored Ionizable Lipid Nanoparticles Facilitate IL‐12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy by Xu, Shufen, Xu, Yue, Solek, Nicholas C., Chen, Jingan, Gong, Fanglin, Varley, Andrew James, Golubovic, Alex, Pan, Anni, Dong, Songtao, Zheng, Gang, Li, Bowen

“…The advancement of message RNA (mRNA) ‐based immunotherapies for cancer is highly dependent on the effective delivery of RNA (Ribonucleic) payloads using…”
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Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects by Chen, Jingan, Xu, Yue, Zhou, Muye, Xu, Shufen, Varley, Andrew James, Golubovic, Alex, Lu, Rick Xing Ze, Wang, Kevin Chang, Yeganeh, Mina, Vosoughi, Daniel, Li, Bowen

“…Ionizable lipid nanoparticles (LNPs) pivotal to the success of COVID-19 mRNA (messenger RNA) vaccines hold substantial promise for expanding the landscape of…”
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Tumor‐Tailored Ionizable Lipid Nanoparticles Facilitate IL‐12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy (Adv. Mater. 29/2024) by Xu, Shufen, Xu, Yue, Solek, Nicholas C., Chen, Jingan, Gong, Fanglin, Varley, Andrew James, Golubovic, Alex, Pan, Anni, Dong, Songtao, Zheng, Gang, Li, Bowen

“…Inhalable RNA Immunotherapy In article number 2400307, Bowen Li and co‐workers develop a tumor‐tailored lipid nanoparticle system to deliver IL‐12 circular RNA…”
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Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry by Li, Bowen, Raji, Idris O., Gordon, Akiva G. R., Sun, Lizhuang, Raimondo, Theresa M., Oladimeji, Favour A., Jiang, Allen Y., Varley, Andrew, Langer, Robert S., Anderson, Daniel G.

“…To unlock the full promise of messenger (mRNA) therapies, expanding the toolkit of lipid nanoparticles is paramount. However, a pivotal component of lipid…”
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Fine mapping of the Cepaea nemoralis shell colour and mid-banded loci using a high-density linkage map by Johansen, Margrethe, Saenko, Suzanne, Schilthuizen, Menno, Blaxter, Mark, Davison, Angus

“…Molluscs are a highly speciose phylum that exhibits an astonishing array of colours and patterns, yet relatively little progress has been made in identifying…”
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Utilizing the Ethylene-releasing Compound, 2-Chloroethylphosphonic Acid, as a Tool to Study Ethylene Response in Bacteria by Augimeri, Richard V., Varley, Andrew J., Strap, Janice L.

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The transcription factor, FixK, plays a central role in carbon source metabolism and cellulose synthesis in Komagataeibacter species by Varley, Andrew James

“…Komagataeibacter xylinus ATCC 53582 and K. hansenii ATCC 23769 are model bacterial cellulose producers. This thesis investigated both carbon source utilization…”
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Cyberspace saint by Varley, Andrew

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Alcohol addiction by Varley, Andrew

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