Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21

Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21

The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+ channel expressed in human heart, has been determined by three independent methodologies: somatic cell hybrid mapping, chromosomal microdissection-polymerase chain reaction, and fluorescence in situ hybridization. T...

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Bibliographic Details
Published in:Cytogenetics and cell genetics Vol. 68; no. 1-2; p. 67
Main Authors: George, Jr, A L, Varkony, T A, Drabkin, H A, Han, J, Knops, J F, Finley, W H, Brown, G B, Ward, D C, Haas, M
Format: Journal Article
Language:English
Published: Switzerland 01-01-1995
Subjects:
Animals
Base Sequence
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 3
DNA Primers
Drug Resistance
Hominidae - genetics
Humans
Hybrid Cells
In Situ Hybridization, Fluorescence
Molecular Sequence Data
Myocardium - metabolism
Polymerase Chain Reaction - methods
Rodentia
Sodium Channels - drug effects
Sodium Channels - genetics
Tetrodotoxin - pharmacology
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Summary:The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+ channel expressed in human heart, has been determined by three independent methodologies: somatic cell hybrid mapping, chromosomal microdissection-polymerase chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the short arm of chromosome 3 (band 3p21) by all three approaches. These data are further evidence that striated muscle Na+ channel genes are dispersed in the genome.
ISSN:0301-0171
DOI:10.1159/000133892