Search Results - "Varisco, M"

A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase by Joshi, Imani, Devine, Andrew J., Joshi, Rashika, Smith, Noah J., Varisco, Brian M.

“…Progressive emphysema often leads to end-stage lung disease. Most mouse models of emphysema are typically modest (i.e. cigarette smoke exposure), and changes…”
Get full text

Peripheral blood transcriptomic sub-phenotypes of pediatric acute respiratory distress syndrome by Yehya, Nadir, Varisco, Brian M, Thomas, Neal J, Wong, Hector R, Christie, Jason D, Feng, Rui

“…Acute respiratory distress syndrome (ARDS) is heterogeneous and may be amenable to sub-phenotyping to improve enrichment for trials. We aimed to identify…”
Get full text

Epigenetic regulation of thy-1 by histone deacetylase inhibitor in rat lung fibroblasts by Sanders, Yan Y, Tollefsbol, Trygve O, Varisco, Brian M, Hagood, James S

“…Thy-1 is a cell surface glycoprotein present on normal lung fibroblasts but absent from the fibroblastic foci of idiopathic pulmonary fibrosis. Thy-1…”
Get full text

Wntless is required for peripheral lung differentiation and pulmonary vascular development by Cornett, Bridget, Snowball, John, Varisco, Brian M., Lang, Richard, Whitsett, Jeffrey, Sinner, Debora

“…Wntless (Wls), a gene highly conserved across the animal kingdom, encodes for a transmembrane protein that mediates Wnt ligand secretion. Wls is expressed in…”
Get full text

Proteomic profiling of tracheal fluid in an ovine model of congenital diaphragmatic hernia and fetal tracheal occlusion by Peiro, Jose Luis, Oria, Marc, Aydin, Emrah, Joshi, Rashika, Cabanas, Nichole, Schmidt, Ronny, Schroeder, Christoph, Marotta, Mario, Varisco, Brian M

“…Congenital diaphragmatic hernia (CDH) occurs in ~1:2,000 pregnancies and is associated with substantial morbidity and mortality. Fetal tracheal occlusion (TO)…”
Get more information

Multi-omic characterization of pediatric ARDS via nasal brushings by Williams, James G, Joshi, Rashika, Haslam, David, Yehya, Nadir, Jones, Rhonda L, Paranjpe, Aditi, Pujato, Mario, Roskin, Krishna M, Lahni, Patrick M, Wong, Hector R, Varisco, Brian M

“…While nasal brushing transcriptomics can identify disease subtypes in chronic pulmonary diseases, it is unknown whether this is true in pediatric acute…”
Get full text

Gene Expression of Disease-related Genes in Alzheimer’s Disease is Impaired by Tau Aggregation by Siano, G., Varisco, M., Scarlatti, A., Caiazza, M.C., Dunville, K., Cremisi, F., Costa, M., Pancrazi, L., Di Primio, C., Cattaneo, A.

“…[Display omitted] •Nuclear Tau undergoes aggregation.•P301S mutant preserves Tau function on VGluT1 expression.•Aggregation in the nucleus leads to Tau loss of…”
Get full text

Lung microstructure in adolescent idiopathic scoliosis before and after posterior spinal fusion by Thomen, Robert P, Woods, Jason C, Sturm, Peter F, Jain, Viral, Walkup, Laura L, Higano, Nara S, Quirk, James D, Varisco, Brian M

“…Adolescent idiopathic scoliosis (AIS) is associated with decreased respiratory quality of life and impaired diaphragm function. Recent hyperpolarized helium…”
Get full text

Nuclear Factor-κB Keeps Basal Cells Undifferentiated in Congenital Diaphragmatic Hernia by Varisco, Brian M

“…Varisco discusses the study by Wagner et al which uses basal cells from the tracheal aspirates of infants with congenital diaphragmatic hernia (CDH) and a rat…”
Get full text

Excessive Reversal of Epidermal Growth Factor Receptor and Ephrin Signaling Following Tracheal Occlusion in Rabbit Model of Congenital Diaphragmatic Hernia by Varisco, Brian M, Sbragia, Lourenco, Chen, Jing, Scorletti, Federico, Joshi, Rashika, Wong, Hector R, Lopes-Figueira, Rebecca, Oria, Marc, Peiro, Jose

“…Congenital diaphragmatic hernia (CDH) causes severe pulmonary hypoplasia from herniation of abdominal contents into the thorax. Tracheal occlusion (TO) for…”
Get full text

Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling by Serapiglia, Vincent, Stephens, Chad A, Joshi, Rashika, Aydin, Emrah, Oria, Marc, Marotta, Mario, Peiro, Jose L, Varisco, Brian M

“…Fetal endoscopic tracheal occlusion (FETO) is an emerging surgical therapy for congenital diaphragmatic hernia (CDH). Ovine and rabbit data suggested altered…”
Get full text

Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model by Atkinson, Sarah J, Varisco, Brian M, Sandquist, Mary, Daly, Meghan N, Klingbeil, Lindsey, Kuethe, Joshua W, Midura, Emily F, Harmon, Kelli, Opaka, Amy, Lahni, Patrick, Piraino, Giovanna, Hake, Paul, Zingarelli, Basilia, Mortenson, Joel E, Wynn, James L, Wong, Hector R

“…Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8 ( ) improves survival in an adult murine sepsis model. Because developmental age…”
Get full text

In Memoriam: Hector R. Wong, MD (1963–2022) by Varisco, Brian M.

Get full text

Mouse lung organoid responses to reduced, increased, and cyclic stretch by Joshi, Rashika, Batie, Matthew R, Fan, Qiang, Varisco, Brian M

“…Most lung development occurs in the context of cyclic stretch. Alteration of the mechanical microenvironment is a common feature of many pulmonary diseases,…”
Get more information

Regulation of epithelial transitional states in murine and human pulmonary fibrosis by Wang, Fa, Ting, Christopher, Riemondy, Kent A, Douglas, Michael, Foster, Kendall, Patel, Nisha, Kaku, Norihito, Linsalata, Alexander, Nemzek, Jean, Varisco, Brian M, Cohen, Erez, Wilson, Jasmine A, Riches, David Wh, Redente, Elizabeth F, Toivola, Diana M, Zhou, Xiaofeng, Moore, Bethany B, Coulombe, Pierre A, Omary, M Bishr, Zemans, Rachel L

“…Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from impaired regeneration of the alveolar epithelium after injury. During…”
Get full text

Biomarker-Based Risk Stratification Tool in Pediatric Acute Respiratory Distress Syndrome: Single-Center, Longitudinal Validation in a 2014-2019 Cohort by Whitney, Jane E, Johnson, Grace M, Varisco, Brian M, Raby, Benjamin A, Yehya, Nadir

“…The Pediatric Acute Respiratory Distress Syndrome Biomarker Risk Model (PARDSEVERE) used age and three plasma biomarkers measured within 24 hours of pediatric…”
Get full text

Shipped but Not Sold: Material Culture and the Social Protocols of Trade during Yemen's Age of Coffee by Varisco, Daniel M.

“…Varisco reviews Shipped but Not Sold: Material Culture and the Social Protocols of Trade during Yemen's Age of Coffee by Nancy Um…”
Get full text

High-Frequency Jet Ventilation Is Making Slow Inroads to the Pediatric ICU by Maxwell, Andrea R, Frazier, Maria, Varisco, Brian M

Get full text

Sex-specific differences in emphysema using a murine antisense oligonucleotide model of α-1 antitrypsin deficiency by Joshi, Rashika, Ojha, Mohit, Lewis, Jana, Fan, Qiang, Monia, Brett, Guo, Shuling, Varisco, Brian M

“…α-1 Antitrypsin (AAT) deficiency is the leading genetic cause of emphysema; however, until recently, no genuine animal models of AAT deficiency existed,…”
Get more information

Comparison of 16 Pediatric Acute Respiratory Distress Syndrome-Associated Plasma Biomarkers With Changing Lung Injury Severity by Williams, James G., Jones, Rhonda L., Yunger, Toni L., Lahni, Patrick M., Yehya, Nadir, Varisco, Brian M.

“…Pediatric acute respiratory distress syndrome (PARDS) is a source of substantial morbidity and mortality in the PICU, and different plasma biomarkers have…”
Get full text