Search Results - "Variath, Prasanna"

Effect of amino acid substitutions at the subunit interface on the stability and aggregation properties of a dimeric protein: Role of Arg 178 and Arg 218 at the dimer interface of thymidylate synthase by Prasanna, Variath, Gopal, B., Murthy, M.R.N., Santi, Daniel V., Balaram, Padmanabhan

“…The significance of two interface arginine residues on the structural integrity of an obligatory dimeric enzyme thymidylate synthase (TS) from Lactobacillus…”
Get full text

Synthetic Interface Peptides as Inactivators of Multimeric Enzymes:  Inhibitory and Conformational Properties of Three Fragments from Lactobacillus casei Thymidylate Synthase by PRASANNA, Variath, BHATTACHARJYA, Surajit, BALARAM, Padmanabhan

“…Three synthetic peptides corresponding to distinct segments of the subunit interface of the dimeric enzyme thymidylate synthase (residues 17-38, N 22; residues…”
Get full text

Synthetic Interface Peptides as Inactivators of Multimeric Enzymes:  Inhibitory and Conformational Properties of Three Fragments from Lactobacillus c asei Thymidylate Synthase by Prasanna, Variath, Bhattacharjya, Surajit, Balaram, Padmanabhan

“…Three synthetic peptides corresponding to distinct segments of the subunit interface of the dimeric enzyme thymidylate synthase (residues 17−38, N 22; residues…”
Get full text

Effects of Subunit Occupancy on Partitioning of an Intermediate in Thymidylate Synthase Mutants by Variath, Prasanna, Liu, Yaoquan, Lee, Tom T, Stroud, Robert M, Santi, Daniel V

“…Experimental evidence for a 5-exocyclic methylene-dUMP intermediate in the thymidylate synthase reaction was recently obtained by demonstrating that tryptophan…”
Get full text