Search Results - "Varhaug, Kristin N."

Neurofilament Light Chain as a Biomarker in Multiple Sclerosis by Varhaug, Kristin N, Torkildsen, Øivind, Myhr, Kjell-Morten, Vedeler, Christian A

“…Due to the unpredictable course and heterogenous treatment response in multiple sclerosis (MS), there is a clear need for biomarkers that reflect disease…”
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Natural Variation of Vitamin D and Neurofilament Light Chain in Relapsing-Remitting Multiple Sclerosis by Røsjø, Egil, Lindstrøm, Jonas C, Holmøy, Trygve, Myhr, Kjell-Morten, Varhaug, Kristin N, Torkildsen, Øivind

“…High serum levels of 25-hydroxyvitamin D (25(OH)D) have been found among patients with a favorable disease course in relapsing-remitting MS (RRMS), indicating…”
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Using urine to diagnose large‐scale mtDNA deletions in adult patients by Varhaug, Kristin N., Nido, Gonzalo S., Coo, Irenaeus, Isohanni, Pirjo, Suomalainen, Anu, Tzoulis, Charalampos, Knappskog, Per, Bindoff, Laurence A.

“…Objective The aim of this study was to evaluate if urinary sediment cells offered a robust alternative to muscle biopsy for the diagnosis of single mtDNA…”
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Neurofilament light chain predicts disease activity in relapsing-remitting MS by Varhaug, Kristin N, Barro, Christian, Bjørnevik, Kjetil, Myhr, Kjell-Morten, Torkildsen, Øivind, Wergeland, Stig, Bindoff, Laurence A, Kuhle, Jens, Vedeler, Christian

“…To investigate whether serum neurofilament light chain (NF-L) and chitinase 3-like 1 (CHI3L1) predict disease activity in relapsing-remitting MS (RRMS). A…”
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Safety of drug use in patients with a primary mitochondrial disease: An international Delphi‐based consensus by De Vries, Maaike C., Brown, David A., Allen, Mitchell E., Bindoff, Laurence, Gorman, Gráinne S., Karaa, Amel, Keshavan, Nandaki, Lamperti, Costanza, McFarland, Robert, Ng, Yi Shiau, O'Callaghan, Mar, Pitceathly, Robert D. S., Rahman, Shamima, Russel, Frans G. M., Varhaug, Kristin N., Schirris, Tom J. J., Mancuso, Michelangelo

“…Clinical guidance is often sought when prescribing drugs for patients with primary mitochondrial disease. Theoretical considerations concerning drug safety in…”
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Elevated cholesterol in ATAD3 mutants is a compensatory mechanism that leads to membrane cholesterol aggregation by Muñoz-Oreja, Mikel, Sandoval, Abigail, Bruland, Ove, Perez-Rodriguez, Diego, Fernandez-Pelayo, Uxoa, de Arbina, Amaia Lopez, Villar-Fernandez, Marina, Hernández-Eguiazu, Haizea, Hernández, Ixiar, Park, Yohan, Goicoechea, Leire, Pascual-Frías, Nerea, Garcia-Ruiz, Carmen, Fernandez-Checa, Jose, Martí-Carrera, Itxaso, Gil-Bea, Francisco Javier, Hasan, Mazahir T, Gegg, Matthew E, Bredrup, Cecilie, Knappskog, Per-Morten, Gereñu-Lopetegui, Gorka, Varhaug, Kristin N, Bindoff, Laurence A, Spinazzola, Antonella, Yoon, Wan Hee, Holt, Ian J

“…Aberrant cholesterol metabolism causes neurological disease and neurodegeneration, and mitochondria have been linked to perturbed cholesterol homeostasis via…”
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Increased levels of cell-free mitochondrial DNA in the cerebrospinal fluid of patients with multiple sclerosis by Varhaug, Kristin N, Vedeler, Christian A, Myhr, Kjell-Morten, Aarseth, Jan Harald, Tzoulis, Charalampos, Bindoff, Laurence A

“…Mitochondrial DNA (mtDNA) can act as damage-associated molecular pattern molecule (DAMP) and initiate an inflammatory response. We hypothesized that the…”
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Mitochondrial complex IV is lost in neurons in the cuprizone mouse model by Varhaug, Kristin N., Kråkenes, Torbjørn, Alme, Maria N., Vedeler, Christian A., Bindoff, Laurence A.

“…•Neurons are affected by cuprizone- treatment.•There is a selective loss of neuronal complex IV after cuprizone exposure.•Mitochondrial dysfunction may play a…”
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Serum neurofilament as a predictor of 10-year grey matter atrophy and clinical disability in multiple sclerosis: a longitudinal study by Lie, Ingrid Anne, Kaçar, Sezgi, Wesnes, Kristin, Brouwer, Iman, Kvistad, Silje S, Wergeland, Stig, Holmøy, Trygve, Midgard, Rune, Bru, Alla, Edland, Astrid, Eikeland, Randi, Gosal, Sonia, Harbo, Hanne F, Kleveland, Grethe, Sørenes, Yvonne S, Øksendal, Nina, Varhaug, Kristin N, Vedeler, Christian A, Barkhof, Frederik, Teunissen, Charlotte E, Bø, Lars, Torkildsen, Øivind, Myhr, Kjell-Morten, Vrenken, Hugo

“…BackgroundThe predictive value of serum neurofilament light chain (sNfL) on long-term prognosis in multiple sclerosis (MS) is still…”
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Management of seizures in patients with primary mitochondrial diseases: consensus statement from the InterERNs Mitochondrial Working Group by Mancuso, Michelangelo, Papadopoulou, Maria T., Ng, Yi Shiau, Ardissone, Anna, Bellusci, Marcello, Bertini, Enrico, Di Vito, Lidia, Evangelista, Teresinha, Fons, Carmen, Hikmat, Omar, Horvath, Rita, Klopstock, Thomas, Kornblum, Cornelia, Lamperti, Costanza, Licchetta, Laura, Molnar, Maria Judit, Varhaug, Kristin N., O'Callaghan, Mar, Pressler, Ronit M., Schiff, Manuel, Servidei, Serenella, Szabo, Nora, Gorman, Gráinne S., Cross, J Helen, Rahman, Shamima

“…Background and purpose Primary mitochondrial diseases (PMDs) are common inborn errors of energy metabolism, with an estimated prevalence of one in 4300. These…”
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Research priorities for mitochondrial disorders: Current landscape and patient and professional views by Thomas, Rhys H., Hunter, Amy, Butterworth, Lyndsey, Feeney, Catherine, Graves, Tracey D., Holmes, Sarah, Hossain, Pushpa, Lowndes, Jo, Sharpe, Jenny, Upadhyaya, Sheela, Varhaug, Kristin N., Votruba, Marcela, Wheeler, Russell, Staley, Kristina, Rahman, Shamima

“…Primary mitochondrial disorders encompass a wide range of clinical presentations and a spectrum of severity. They currently lack effective disease‐modifying…”
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Serum biomarkers in primary mitochondrial disorders by Varhaug, Kristin N, Hikmat, Omar, Nakkestad, Hanne Linda, Vedeler, Christian A, Bindoff, Laurence A

“…Abstract The aim of this study was to explore the utility of the serum biomarkers neurofilament light chain, fibroblast growth factor 21 and growth and…”
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Comment on “A severe linezolid‐induced rhabdomyolysis and lactic acidosis in Leigh syndrome” by Bindoff, Laurence A., Brown, David A., Gorman, Gráinne S., Karaa, Amel, Keshavan, Nandaki, Lamperti, Constanza, Mancuso, Michelangelo, McFarland, Robert, Ng, Yi Shiau, O'Callaghan, Mar, Pitceathly, Robert D. S., Rahman, Shamima, Russel, Frans G. M., Schirris, Tom J. J., Varhaug, Kristin N., De Vries, Maaike C.

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Mitochondrial disease caused by the m.3243A>G mutation by Varhaug, Kristin N, Hikmat, Omar, Bindoff, Laurence A

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Eye disease with myotonic dystrophy type 1 by Boonstra, Nils-Erik, Varhaug, Kristin N

“…Myotonic dystrophy type 1 is one of the most common genetic neuromuscular diseases in adults. The disease not only affects the musculoskeletal system, but is…”
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Øyesykdom ved dystrophia myotonica type 1 by Boonstra, Nils-Erik, Varhaug, Kristin N.

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Mitokondriesykdom forårsaket av m.3243A>G-mutasjonen by Varhaug, Kristin N., Hikmat, Omar, Bindoff, Laurence A.

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Multiple sclerosis - a mitochondria-mediated disease? by Varhaug, Kristin N, Vedeler, Christian A, Tzoulis, Charalampos, Bindoff, Laurence A

“…BACKGROUND Mitochondria play an important role in the pathogenesis of various neurodegenerative disorders, including Parkinson's disease. Neurodegenerative…”
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Multippel sklerose - en mitokondriemediert sykdom? by Varhaug, Kristin Nielsen, Vedeler, Christian A, Tzoulis, Charalampos, Bindoff, Laurence A

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