Search Results - "Vargo, Melissa A"

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo by Lucas, David M., Edwards, Ryan B., Lozanski, Gerard, West, Derek A., Shin, Jungook D., Vargo, Melissa A., Davis, Melanie E., Rozewski, Darlene M., Johnson, Amy J., Su, Bao-Ning, Goettl, Virginia M., Heerema, Nyla A., Lin, Thomas S., Lehman, Amy, Zhang, Xiaoli, Jarjoura, David, Newman, David J., Byrd, John C., Kinghorn, A. Douglas, Grever, Michael R.

“…Therapeutic options for advanced B-cell acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) are limited. Available treatments can also…”
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Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis by Vargo, Melissa A, Martucci, W Edward, Anderson, Karen S

“…In contrast with most species, including humans, which have monofunctional forms of the folate biosynthetic enzymes TS (thymidylate synthase) and DHFR…”
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Apigenin Blocks Lipopolysaccharide-Induced Lethality In Vivo and Proinflammatory Cytokines Expression by Inactivating NF-κB through the Suppression of p65 Phosphorylation by Nicholas, Courtney, Batra, Sanjay, Vargo, Melissa A., Voss, Oliver H., Gavrilin, Mikhail A., Wewers, Mark D., Guttridge, Denis C., Grotewold, Erich, Doseff, Andrea I.

“…Abstract LPS stimulates monocytes/macrophages through the activation of signaling events that modulate the production of inflammatory cytokines. Apigenin, a…”
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Apigenin-induced-apoptosis is mediated by the activation of PKCδ and caspases in leukemia cells by Vargo, Melissa A., Voss, Oliver H., Poustka, Frantisek, Cardounel, Arturo J., Grotewold, Erich, Doseff, Andrea I.

“…Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly…”
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First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling by Sharma, Hitesh, Landau, Mark J, Vargo, Melissa A, Spasov, Krasimir A, Anderson, Karen S

“…Most species, such as humans, have monofunctional forms of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) that are key folate metabolism enzymes…”
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Subunit Interface Residues of Glutathione S-Transferase A1-1 that Are Important in the Monomer−Dimer Equilibrium by Vargo, Melissa A, Nguyen, Lucia, Colman, Roberta F

“…Alpha class glutathione S-transferase, isozyme A1-1, is a dimer (51 kDa) of identical subunits. Using the crystal structure, two main areas of subunit…”
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Explaining an Unusually Fast Parasitic Enzyme: Folate Tail-Binding Residues Dictate Substrate Positioning and Catalysis in Cryptosporidium hominis Thymidylate Synthase by Martucci, W. Edward, Vargo, Melissa A, Anderson, Karen S

“…The essential enzyme TS-DHFR from Cryptosporidium hominis undergoes an unusually rapid rate of catalysis at the conserved TS domain, facilitated by two…”
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Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen by Edward Martucci, W., Udier-Blagovic, Marina, Atreya, Chloe, Babatunde, Oladapo, Vargo, Melissa A., Jorgensen, William L., Anderson, Karen S.

“…The essential enzyme thymidylate synthase-dihydrofolate reductase (TS-DHFR) is a validated drug target for many pathogens, but has been elusive in…”
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Nonconserved Residues Ala287 and Ser290 of the Cryptosporidium hominis Thymidylate Synthase Domain Facilitate Its Rapid Rate of Catalysis by Doan, Lanxuan T, Martucci, W. Edward, Vargo, Melissa A, Atreya, Chloé E, Anderson, Karen S

“…Cryptosporidium hominis TS-DHFR exhibits an unusually high rate of catalysis at the TS domain, at least 10-fold greater than those of other TS enzymes. Using…”
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Heterodimers of wild‐type and subunit interface mutant enzymes of glutathione S‐transferase A1–1: Interactive or independent active sites? by Vargo, Melissa A., Colman, Roberta F.

“…Heterodimers of rat glutathione S‐transferase A1–1 were formed using one wild‐type subunit and one subunit with a mutation at the interface to evaluate whether…”
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Chemical modification at subunit 1 of rat kidney Alpha class glutathione transferase with 2,3,5,6-tetrachloro-1,4-benzoquinone: Close structural connectivity between glutathione conjugation activity and non-substrate ligand binding by O'Sullivan, Siobhan M., McCarthy, Ronan M., Vargo, Melissa A., Colman, Roberta F., Sheehan, David

“…2, 3, 5, 6-Tetrachloro-1, 4-benzoquinone (TCBQ) is a metabolite of pentachlorophenol known to react with cysteines of glutathione transferases (GSTs). TCBQ…”
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Explaining an Unusually Fast Parasitic Enzyme: Folate Tail-Binding Residues Dictate Substrate Positioning and Catalysis in by Martucci, W. Edward, Vargo, Melissa A., Anderson, Karen S.

“…The essential enzyme TS-DHFR from Cryptosporidium hominis undergoes an unusually rapid rate of catalysis at the conserved TS domain, facilitated by two…”
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Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells by Vargo, Melissa A, Voss, Oliver H, Poustka, Frantisek, Cardounel, Arturo J, Grotewold, Erich, Doseff, Andrea I

“…Apigenin, a flavone abundantly found in fruits and vegetables, exhibits antiproliferative, anti-inflammatory, and antimetastatic activities through poorly…”
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Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation by Nicholas, Courtney, Batra, Sanjay, Vargo, Melissa A, Voss, Oliver H, Gavrilin, Mikhail A, Wewers, Mark D, Guttridge, Denis C, Grotewold, Erich, Doseff, Andrea I

“…LPS stimulates monocytes/macrophages through the activation of signaling events that modulate the production of inflammatory cytokines. Apigenin, a flavonoid…”
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Affinity Labeling of Rat Glutathione S-Transferase Isozyme 1-1 by 17β-Iodoacetoxy-estradiol-3-sulfate by Melissa A. Vargo, Roberta F. Colman

“…Rat liver glutathione S -transferase, isozyme 1-1, catalyzes the glutathione-dependent isomerization of Δ 5 -androstene-3,17-dione and also binds steroid…”
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Affinity Labeling of Rat Glutathione S-Transferase Isozyme 1-1 by 17β-Iodoacetoxy-estradiol-3-sulfate by Vargo, Melissa A., Colman, Roberta F.

“…Rat liver glutathione S-transferase, isozyme 1-1, catalyzes the glutathione-dependent isomerization of Δ5-androstene-3,17-dione and also binds steroid sulfates…”
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Glutathione S-transferase A1-1: Affinity labeling of the nonsubstrate site and probing interface interactions using mutagenesis by Vargo, Melissa A

“…The affinity label 17beta-iodoacetoxy-estradiol-3-sulfate was used to elucidate binding determinants of the nonsubstrate steroid binding site of glutathione…”
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Glutathione S -transferase A1-1: Affinity labeling of the nonsubstrate site and probing interface interactions using mutagenesis by Vargo, Melissa A

“…The affinity label 17β-iodoacetoxy-estradiol-3-sulfate was used to elucidate binding determinants of the nonsubstrate steroid binding site of glutathione…”
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Apigenin Blocks Lipopolysaccharide-Induced Lethality In Vivo and Proinflammatory Cytokines Expression by Inactivating NF-{kappa}B through the Suppression of p65 Phosphorylation by Nicholas, Courtney, Batra, Sanjay, Vargo, Melissa A, Voss, Oliver H, Gavrilin, Mikhail A, Wewers, Mark D, Guttridge, Denis C, Grotewold, Erich, Doseff, Andrea I

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