Search Results - "Vargiu, Giulia"

Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery by Booth, Daniel G, Takagi, Masatoshi, Sanchez-Pulido, Luis, Petfalski, Elizabeth, Vargiu, Giulia, Samejima, Kumiko, Imamoto, Naoko, Ponting, Chris P, Tollervey, David, Earnshaw, William C, Vagnarelli, Paola

“…When the nucleolus disassembles during open mitosis, many nucleolar proteins and RNAs associate with chromosomes, establishing a perichromosomal compartment…”
Get full text

Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance by Molina, Oscar, Vargiu, Giulia, Abad, Maria Alba, Zhiteneva, Alisa, Jeyaprakash, A. Arockia, Masumoto, Hiroshi, Kouprina, Natalay, Larionov, Vladimir, Earnshaw, William C.

“…Centromeres consist of specialized centrochromatin containing CENP-A nucleosomes intermingled with H3 nucleosomes carrying transcription-associated…”
Get full text

Activity of Birinapant, a SMAC Mimetic Compound, Alone or in Combination in NSCLCs With Different Mutations by Colombo, Marika, Marabese, Mirko, Vargiu, Giulia, Broggini, Massimo, Caiola, Elisa

“…Liver kinase B1 ( LKB1/STK11 ) is the second tumor suppressor gene most frequently mutated in non-small-cell lung cancer (NSCLC) and its activity is impaired…”
Get full text

Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly by Hori, Tetsuya, Shang, Wei-Hao, Toyoda, Atsushi, Misu, Sadahiko, Monma, Norikazu, Ikeo, Kazuho, Molina, Oscar, Vargiu, Giulia, Fujiyama, Asao, Kimura, Hiroshi, Earnshaw, William C., Fukagawa, Tatsuo

“…In vertebrate cells, centromeres are specified epigenetically through the deposition of the centromere-specific histone CENP-A. Following CENP-A deposition,…”
Get full text

Stepwise unfolding supports a subunit model for vertebrate kinetochores by Vargiu, Giulia, Makarov, Alexandr A., Allan, James, Fukagawa, Tatsuo, Booth, Daniel G., Earnshaw, William C.

“…During cell division, interactions between microtubules and chromosomes are mediated by the kinetochore, a proteinaceous structure located at the primary…”
Get full text

Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1 by Mattiuzzo, Marta, Vargiu, Giulia, Totta, Pierangela, Fiore, Mario, Ciferri, Claudio, Musacchio, Andrea, Degrassi, Francesca

“…Highly Expressed in Cancer protein 1 (Hec1) is a constituent of the Ndc80 complex, a kinetochore component that has been shown to have a fundamental role in…”
Get full text

Auxin/AID versus conventional knockouts: distinguishing the roles of CENP-T/W in mitotic kinetochore assembly and stability by Wood, Laura, Booth, Daniel G., Vargiu, Giulia, Ohta, Shinya, deLima Alves, Flavia, Samejima, Kumiko, Fukagawa, Tatsuo, Rappsilber, Juri, Earnshaw, William C.

“…Most studies using knockout technologies to examine protein function have relied either on shutting off transcription (conventional conditional knockouts with…”
Get full text

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis by Samejima, Kumiko, Platani, Melpomeni, Wolny, Marcin, Ogawa, Hiromi, Vargiu, Giulia, Knight, Peter J., Peckham, Michelle, Earnshaw, William C.

“…The chromosome passenger complex (CPC) is a master regulator of mitosis. Inner centromere protein (INCENP) acts as a scaffold regulating CPC localization and…”
Get full text

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase IIα by Samejima, Kumiko, Samejima, Itaru, Vagnarelli, Paola, Ogawa, Hiromi, Vargiu, Giulia, Kelly, David A, de Lima Alves, Flavia, Kerr, Alastair, Green, Lydia C, Hudson, Damien F, Ohta, Shinya, Cooke, Carol A, Farr, Christine J, Rappsilber, Juri, Earnshaw, William C

“…Mitotic chromosome formation involves a relatively minor condensation of the chromatin volume coupled with a dramatic reorganization into the characteristic…”
Get full text

In vitro BioID: mapping the CENP-A microenvironment with high temporal and spatial resolution by Remnant, Lucy, Booth, Daniel G, Vargiu, Giulia, Spanos, Christos, Kerr, Alastair R W, Earnshaw, William C

“…The centromere is located at the primary constriction of condensed chromosomes where it acts as a platform regulating chromosome segregation. The histone H3…”
Get full text

Studying the structure of vertebrate kinetochore using a high-resolution microscopy approach by Vargiu, Giulia

“…The kinetochore is a highly complex proteinaceous structure located at the primary constriction of mitotic chromosomes. Here, it performs an essential role in…”
Get full text

Mitotic chromosomes are compacted laterally by KIF4 and condensin and axially by topoisomerase II[alpha] by Samejima, Kumiko, Samejima, Itaru, Vagnarelli, Paola, Ogawa, Hiromi, Vargiu, Giulia, Kelly, David A, Alves, Flavia de Lima, Kerr, Alastair, Green, Lydia C, Hudson, Damien F, Ohta, Shinya, Cooke, Carol A, Farr, Christine J, Rappsilber, Juri, Earnshaw, William C

“…Mitotic chromosome formation involves a relatively minor condensation of the chromatin volume coupled with a dramatic reorganization into the characteristic…”
Get full text