Search Results - "Varghese, N"

The molecular regulation of Janus kinase (JAK) activation by Babon, Jeffrey J, Lucet, Isabelle S, Murphy, James M, Nicola, Nicos A, Varghese, Leila N

“…The JAK (Janus kinase) family members serve essential roles as the intracellular signalling effectors of cytokine receptors. This family, comprising JAK1,…”
Get more information

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity by Babon, Jeffrey J., Kershaw, Nadia J., Murphy, James M., Varghese, Leila N., Laktyushin, Artem, Young, Samuel N., Lucet, Isabelle S., Norton, Raymond S., Nicola, Nicos A.

“…Janus kinases (JAKs) are key effectors in controlling immune responses and maintaining hematopoiesis. SOCS3 (suppressor of cytokine signaling-3) is a major…”
Get full text

Inhibition of IL-6 family cytokines by SOCS3 by Babon, Jeffrey J, Varghese, Leila N, Nicola, Nicos A

“…Highlights • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response…”
Get full text

Oral Health and Quality of Life: Current Concepts by Baiju, R M, Peter, Elbe, Varghese, N O, Sivaram, Remadevi

“…The recognition of health related quality of life began ever since WHO expanded the definition of health in 1948. This has resulted in the paradigm shift of…”
Get full text

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism by Murphy, James M., Czabotar, Peter E., Hildebrand, Joanne M., Lucet, Isabelle S., Zhang, Jian-Guo, Alvarez-Diaz, Silvia, Lewis, Rowena, Lalaoui, Najoua, Metcalf, Donald, Webb, Andrew I., Young, Samuel N., Varghese, Leila N., Tannahill, Gillian M., Hatchell, Esme C., Majewski, Ian J., Okamoto, Toru, Dobson, Renwick C.J., Hilton, Douglas J., Babon, Jeffrey J., Nicola, Nicos A., Strasser, Andreas, Silke, John, Alexander, Warren S.

“…Mixed lineage kinase domain-like (MLKL) is a component of the “necrosome,” the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell…”
Get full text

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition by Kershaw, Nadia J, Murphy, James M, Liau, Nicholas P D, Varghese, Leila N, Laktyushin, Artem, Whitlock, Eden L, Lucet, Isabelle S, Nicola, Nicos A, Babon, Jeffrey J

“…The inhibitory protein SOCS3 plays a key part in hematopoiesis by regulating signaling induced by specific cytokines. The crystal structure of SOCS3 bound to…”
Get full text

Exploring the Link between Metabolic Remodelling and Reactive Oxygen Species in the Aged and Diseased Heart by Varghese, Lijo N, Katare, Rajesh

Get full text

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties by Murphy, James M, Zhang, Qingwei, Young, Samuel N, Reese, Michael L, Bailey, Fiona P, Eyers, Patrick A, Ungureanu, Daniela, Hammaren, Henrik, Silvennoinen, Olli, Varghese, Leila N, Chen, Kelan, Tripaydonis, Anne, Jura, Natalia, Fukuda, Koichi, Qin, Jun, Nimchuk, Zachary, Mudgett, Mary Beth, Elowe, Sabine, Gee, Christine L, Liu, Ling, Daly, Roger J, Manning, Gerard, Babon, Jeffrey J, Lucet, Isabelle S

“…Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl transfer, termed pseudokinases, have emerged as important signalling…”
Get more information

Neuronal function spontaneously recovers in organotypic hippocampal slice cultures after repetitive exposure to occupational-level shock waves by Kim, C. Y., Varghese, N., Kleinberger, M., Morrison, B.

“…Blast-induced traumatic brain injury has long been a prevalent health issue. There is growing concern for repeated exposures to low-level blasts with studies…”
Get full text

Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop by Tanzer, Maria C, Tripaydonis, Anne, Webb, Andrew I, Young, Samuel N, Varghese, Leila N, Hall, Cathrine, Alexander, Warren S, Hildebrand, Joanne M, Silke, John, Murphy, James M

“…The pseudokinase MLKL (mixed lineage kinase domain-like), has recently emerged as a critical component of the necroptosis cell death pathway. Although it is…”
Get more information

The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin by Varghese, Leila N, Defour, Jean-Philippe, Pecquet, Christian, Constantinescu, Stefan N

“…A well-functioning hematopoietic system requires a certain robustness and flexibility to maintain appropriate quantities of functional mature blood cells, such…”
Get full text

Naturally occurring polyphenolic inhibitors of amyloid beta aggregation by Churches, Quentin I., Caine, Joanne, Cavanagh, Kate, Epa, Vidana Chandana, Waddington, Lynne, Tranberg, C. Elisabet, Meyer, Adam G., Varghese, Jose N., Streltsov, Victor, Duggan, Peter J.

“…Alzheimer’s disease is the most common neurodegenerative disease and is one of the main causes of death in developed countries. Consumption of foods rich in…”
Get full text

Resistance to torsional failure and cyclic fatigue resistance of ProTaper Next, WaveOne, and Mtwo files in continuous and reciprocating motion: An in vitro study by Varghese, N, Pillai, Rajesh, Sujathen, U-Nu, Sainudeen, Shan, Antony, Abe, Paul, Sinju

“…Aims: The purpose of this study was to evaluate the resistance to torsional failure and cyclic fatigue resistance of ProTaper Next (PTN), WaveOne, and Mtwo…”
Get full text

Complementary Metagenomic Approaches Improve Reconstruction of Microbial Diversity in a Forest Soil by Alteio, L V, Schulz, F, Seshadri, R, Varghese, N, Rodriguez-Reillo, W, Ryan, E, Goudeau, D, Eichorst, S A, Malmstrom, R R, Bowers, R M, Katz, L A, Blanchard, J L, Woyke, T

“…Soil ecosystems harbor diverse microorganisms and yet remain only partially characterized as neither single-cell sequencing nor whole-community sequencing…”
Get full text

Do children of working mothers experience more dental caries? by Baiju, R, Peter, Elbe, Narayan, Vivek, Varughese, Jolly, Varghese, N

“…Background: Pain and discomfort due to untreated dental caries lead to eating and sleep disruptions, behavioral changes, and poor quality of life. Among…”
Get full text

Ethics, zoonoses, and human-nonhuman conflict: Covid-19 and beyond by Humphreys, R, Chakraborty, R, Varghese, N

“…While the causes of human-animal conflict are numerous, many are intertwined with food production systems and the wildlife trade. The emergence and spread of…”
Get full text

A typical acute lymphoblastic leukemia JAK2 variant, R683G, causes an aggressive form of familial thrombocytosis when germline by Carreño-Tarragona, Gonzalo, Varghese, Leila N., Sebastián, Elena, Gálvez, Eva, Marín-Sánchez, Alberto, López-Muñoz, Nieves, Nam-Cha, Syonghyun, Martínez-López, Joaquín, Constantinescu, Stefan N., Sevilla, Julián, Ayala, Rosa

Get full text

Role of noncoding RNAs in cardiac ageing by Varghese, Lijo N, Schwenke, Daryl O, Katare, Rajesh

“…The global population is estimated to reach 9.8 billion by 2050, of which 2.1 billion will comprise individuals above 60 years of age. As the number of elderly…”
Get full text

An in vitro study of comparative evaluation of efficacy of electrochemically activated water as a root canal irrigant in smear layer removal by Mahesh, M, Pillai, Rajesh, Varghese, N, Salim, Afzal, Murali, Nikhil, Nair, Saranya

“…Aim: The aim was to compare and evaluate the efficacy of electrochemically activated water (ECA) against maleic acid, Mixture of tetracycline, acid and…”
Get full text

Oral health-related quality of life in surgery-first vs traditional orthognathic approach by Peter, Elbe, Baiju, R.M., Kumar, Sreejith, Varghese, N.O.

Get full text