Search Results - "Vargas Honorato, Rodrigo"
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ParKVFinder: A thread-level parallel approach in biomolecular cavity detection
Published in SoftwareX (01-07-2020)“…Biological processes are regulated mainly by the binding of small molecules into cavities distributed throughout the biomolecular structure. Computational…”
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Kinase inhibitor profile for human nek1, nek6, and nek7 and analysis of the structural basis for inhibitor specificity
Published in Molecules (Basel, Switzerland) (13-01-2015)“…Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential drug targets for the…”
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Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO)
Published in PloS one (07-10-2013)“…Cytoskeleton and protein trafficking processes, including vesicle transport to synapses, are key processes in neuronal differentiation and axon outgrowth. The…”
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Structural Biology in the Clouds: The WeNMR-EOSC Ecosystem
Published in Frontiers in molecular biosciences (28-07-2021)“…Structural biology aims at characterizing the structural and dynamic properties of biological macromolecules at atomic details. Gaining insight into three…”
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Oligomerization as a strategy for cold adaptation: Structure and dynamics of the GH1 β-glucosidase from Exiguobacterium antarcticum B7
Published in Scientific reports (31-03-2016)“…Psychrophilic enzymes evolved from a plethora of structural scaffolds via multiple molecular pathways. Elucidating their adaptive strategies is instrumental to…”
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Molecular Mechanisms Associated with Xylan Degradation by Xanthomonas Plant Pathogens
Published in The Journal of biological chemistry (14-11-2014)“…Xanthomonas pathogens attack a variety of economically relevant plants, and their xylan CUT system (carbohydrate utilization with TonB-dependent outer membrane…”
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Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor
Published in The Journal of biological chemistry (27-09-2013)“…The phosphate-dependent transition between enzymatically inert dimers into catalytically capable tetramers has long been the accepted mechanism for the…”
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Structural basis of exo-β-mannanase activity in the GH2 family
Published in The Journal of biological chemistry (31-08-2018)“…The classical microbial strategy for depolymerization of β-mannan polysaccharides involves the synergistic action of at least two enzymes,…”
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Pyrrole-indolinone SU11652 targets the nucleoside diphosphate kinase from Leishmania parasites
Published in Biochemical and biophysical research communications (01-07-2017)“…Nucleoside diphosphate kinases (NDKs) are key enzymes in the purine-salvage pathway of trypanosomatids and have been associated with the maintenance of…”
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Negative regulation of bacterial killing and inflammation by two novel CD16 ligands
Published in European journal of immunology (01-08-2016)“…Sepsis, a leading cause of death worldwide, involves exacerbated proinflammatory responses and inefficient bacterial clearance. Phagocytic cells play a crucial…”
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Combining Mass Spectrometry Cross‐Linking, Molecular Docking and NMR Titration to Dissect ZapA‐FtsZ Protein Interaction
Published in The FASEB journal (01-04-2016)“…Abstract only The cell division is a key event in a bacteria cycle of life and in most rod shaped bacteria. This cell divion involves a septum formation. FtsZ…”
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Oligomerization as a strategy for cold adaptation: Structure and dynamics of the GH1 [beta]-glucosidase from Exiguobacterium antarcticum B7
Published in Scientific reports (01-03-2016)“…Psychrophilic enzymes evolved from a plethora of structural scaffolds via multiple molecular pathways. Elucidating their adaptive strategies is instrumental to…”
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13
The mechanism by which a distinguishing arabinofuranosidase can cope with internal di-substitutions in arabinoxylans
Published in Biotechnology for biofuels (11-08-2018)“…Arabinoxylan is an abundant polysaccharide in industrially relevant biomasses such as sugarcane, corn stover and grasses. However, the arabinofuranosyl…”
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14
Structural biology in the clouds: The WeNMR-EOSC Ecosystem
Published 02-07-2021“…Structural biology aims at characterizing the structural and dynamic properties of biological macromolecules at atomic details. Gaining insight into three…”
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