Search Results - "Vargas, Servando Hernandez"

Development of a drug–device combination for fluorescence-guided surgery in neuroendocrine tumors by Hernandez Vargas, Servando, Lin, Christie, Voss, Julie, Ghosh, Sukhen C, Halperin, Daniel M, AghaAmiri, Solmaz, Cao, Hop S. Tran, Ikoma, Naruhiko, Uselmann, Adam J, Azhdarinia, Ali

“…Significance: The use of cancer-targeted contrast agents in fluorescence-guided surgery (FGS) has the potential to improve intraoperative visualization of…”
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Targeted Dual-Modal PET/SPECT-NIR Imaging: From Building Blocks and Construction Strategies to Applications by Usama, Syed Muhammad, Marker, Sierra C, Hernandez Vargas, Servando, AghaAmiri, Solmaz, Ghosh, Sukhen C, Ikoma, Naruhiko, Tran Cao, Hop S, Schnermann, Martin J, Azhdarinia, Ali

“…Molecular imaging is an emerging non-invasive method to qualitatively and quantitively visualize and characterize biological processes. Among the imaging…”
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Receptor-Targeted Fluorescence-Guided Surgery With Low Molecular Weight Agents by Hernandez Vargas, Servando, Lin, Christie, Tran Cao, Hop S., Ikoma, Naruhiko, AghaAmiri, Solmaz, Ghosh, Sukhen C., Uselmann, Adam J., Azhdarinia, Ali

“…Cancer surgery remains the primary treatment option for most solid tumors and can be curative if all malignant cells are removed. Surgeons have historically…”
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Comparison of HER2-Targeted Antibodies for Fluorescence-Guided Surgery in Breast Cancer by AghaAmiri, Solmaz, Simien, Jo, Thompson, Alastair M., Voss, Julie, Ghosh, Sukhen C., Hernandez Vargas, Servando, Kim, Sarah, Azhdarinia, Ali, Tran Cao, Hop S.

“…Background. Although therapeutic advances have led to enhanced survival in patients with human epidermal growth factor receptor 2 (HER2)-positive breast…”
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New Developments in Dual-Labeled Molecular Imaging Agents by Hernandez Vargas, Servando, Ghosh, Sukhen C, Azhdarinia, Ali

“…Intraoperative detection of tumors has had a profound impact on how cancer surgery is performed and addresses critical unmet needs in surgical oncology. Tumor…”
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A translational blueprint for developing intraoperative imaging agents via radiopharmaceutical-guided drug design by Sullivan, Teresa E., Vargas, Servando Hernandez, Ghosh, Sukhen C., AghaAmiri, Solmaz, Ikoma, Naruhiko, Azhdarinia, Ali

“…Cancer imaging is a rapidly evolving field due to the discovery of novel molecular targets and the availability of corresponding techniques to detect them with…”
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A simple and rapid in vitro assay for identification of direct inhibitors of O6-methylguanine-DNA methyltransferase by Khalaj, Vahid, AghaAmiri, Solmaz, Ghosh, Sukhen C, Vargas, Servando Hernandez, Momeny, Majid, Azhdarinia, Ali

“…O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that is overexpressed in certain tumors and is associated with resistance to the DNA…”
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Specific Targeting of Somatostatin Receptor Subtype-2 for Fluorescence-Guided Surgery by Hernandez Vargas, Servando, Kossatz, Susanne, Voss, Julie, Ghosh, Sukhen C, Tran Cao, Hop S, Simien, Jo, Reiner, Thomas, Dhingra, Sadhna, Fisher, William E, Azhdarinia, Ali

“…Clinically available intraoperative imaging tools to assist surgeons in identifying occult lesions are limited and partially responsible for the high rate of…”
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Translational Potential of a Contrast Agent for FGS Applications in pNETs by AghaAmiri, Solmaz, Estrella, Jeannelyn S., Vargas, Servando Hernandez, Hurd, Mark W., Ghosh, Sukhen C., Azhdarinia, Ali, Ikoma, Naruhiko

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Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine by Buettner, Ralf, Nguyen, Le Xuan Truong, Morales, Corey, Chen, Min-Hsuan, Wu, Xiwei, Chen, Lisa S, Hoang, Dinh Hoa, Hernandez Vargas, Servando, Pullarkat, Vinod, Gandhi, Varsha, Marcucci, Guido, Rosen, Steven T

“…BCL-2 inhibition through venetoclax (VEN) targets acute myeloid leukemia (AML) blast cells and leukemic stem cells (LSCs). Although VEN-containing regimens…”
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High-Contrast Detection of Somatostatin Receptor Subtype‑2 for Fluorescence-Guided Surgery by Hernandez Vargas, Servando, AghaAmiri, Solmaz, Ghosh, Sukhen C., Luciano, Michael P., Borbon, Luis C., Ear, Po Hien, Howe, James R., Bailey-Lundberg, Jennifer M., Simonek, Gregory D., Halperin, Daniel M., Tran Cao, Hop S., Ikoma, Naruhiko, Schnermann, Martin J., Azhdarinia, Ali

“…Dye design can influence the ability of fluorescently labeled imaging agents to generate tumor contrast and has become an area of significant interest in the…”
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Evaluation of Anti-LGR5 Antibodies by ImmunoPET for Imaging Colorectal Tumors and Development of Antibody–Drug Conjugates by Azhdarinia, Ali, Voss, Julie, Ghosh, Sukhen C, Simien, Jo A, Hernandez Vargas, Servando, Cui, Jie, Yu, Wangsheng A, Liu, Qingyun, Carmon, Kendra S

“…Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is highly expressed in colorectal tumors and marks colon cancer stem cells that drive tumor…”
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Establishment of Novel Neuroendocrine Carcinoma Patient-Derived Xenograft Models for Receptor Peptide-Targeted Therapy by Tran, Catherine G, Borbon, Luis C, Mudd, Jacqueline L, Abusada, Ellen, AghaAmiri, Solmaz, Ghosh, Sukhen C, Vargas, Servando Hernandez, Li, Guiying, Beyer, Gabriella V, McDonough, Mary, Li, Rachel, Chan, Carlos H F, Walsh, Susan A, Wadas, Thaddeus J, O'Dorisio, Thomas, O'Dorisio, M Sue, Govindan, Ramaswamy, Cliften, Paul F, Azhdarinia, Ali, Bellizzi, Andrew M, Fields, Ryan C, Howe, James R, Ear, Po Hien

“…Gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) are rare cancers consisting of neuroendocrine carcinomas (NECs) and neuroendocrine tumors (NETs),…”
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A simple and rapid in vitro assay for identification of direct inhibitors of O 6 -methylguanine-DNA methyltransferase by Khalaj, Vahid, AghaAmiri, Solmaz, Ghosh, Sukhen C, Vargas, Servando Hernandez, Momeny, Majid, Azhdarinia, Ali

“…O -Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that is overexpressed in certain tumors and is associated with resistance to the DNA…”
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Somatostatin Receptor Subtype‑2 Targeting System for Specific Delivery of Temozolomide by AghaAmiri, Solmaz, Ghosh, Sukhen C., Hernandez Vargas, Servando, Halperin, Daniel M., Azhdarinia, Ali

“…Temozolomide (TMZ) is a DNA alkylating agent that produces objective responses in patients with neuroendocrine tumors (NETs) when the DNA repair enzyme…”
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Abstract LB120: A novel peptide-drug conjugate induces DNA damage in SSTR2-expressing cells by AghaAmiri, Solmaz, Ghosh, Sukhen C., Stitzlein, Lea, Vargas, Servando Hernandez, Perlatti, Bruno, Halperin, Daniel M., Azhdarinia, Ali

“…Abstract Introductory statement: To overcome enzyme-mediated resistance mechanisms associated with the DNA alkylating agent, temozolomide (TMZ), we seek to…”
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A highly specific somatostatin analog for fluorescence-guided surgery by Vargas, Servando Hernandez, Ghosh, Sukhen, Voss, Julie, Simien, Jo, Kossatz, Susanne, Reiner, Thomas, Azhdarinia, Ali

“…Objectives: The introduction of contrast agents for fluorescence-guided surgery (FGS) has equipped surgeons with real-time imaging to complement standard…”
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Abstract 5953: DUSP6 is a novel target in neuroendocrine tumors by Momeny, Majid, Khalaj, Vahid, AghaAmiri, Solmaz, Ear, Po Hien, Vargas, Servando Hernandez, Ghosh, Sukhen, Azhdarinia, Ali

“…Abstract Background: Neuroendocrine tumors (NETs) are rare malignancies derived from enterochromaffin cells of the diffuse neuroendocrine system and most…”
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Characterization of a dual-labeled somatostatin analog for fluorescence-guided surgery by Vargas, Servando Hernandez, Voss, Julie, Ghosh, Sukhen C, Simien, Jo, Azhdarinia, Ali

“…Objectives: Surgery is the primary treatment option for most solid tumors and can be curative if all cancer cells are removed. For several types of…”
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Arenicolins: C‑Glycosylated Depsides from Penicillium arenicola by Perlatti, Bruno, Lan, Nan, Earp, Cody E, AghaAmiri, Solmaz, Vargas, Servando Hernandez, Azhdarinia, Ali, Bills, Gerald F, Gloer, James B

“…During investigation of the secondary metabolism of four strains of Penicillium arenicola, two new depsides, arenicolins A (1) and B (2), were isolated and…”
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