Search Results - "Vargas, Mariángela"

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms by León, Guillermo, Herrera, María, Segura, Álvaro, Villalta, Mauren, Vargas, Mariángela, Gutiérrez, José María

“…Snake antivenoms are formulations of immunoglobulins, or immunoglobulin fragments, purified from the plasma of animals immunized with snake venoms. Their…”
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Design, development and preclinical assessment of MENAVip-ICP, a new snake antivenom with potential coverage of species in the Middle East and North Africa regions by Segura, Álvaro, Moscoso, Edwin, Umaña, Deibid, Vargas, Mariángela, Sánchez, Andrés, Hernández, Andrés, Durán, Gina, Villalta, Mauren, Gómez, Aarón, Herrera, María, Arguedas, Mauricio, Gutiérrez, José María, León, Guillermo

“…Snakebite in the Middle East and North Africa (MENA) is a public health problem whose magnitude is not fully known. Several antivenoms are available in these…”
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Assessment of snake antivenom purity by comparing physicochemical and immunochemical methods by Segura, Álvaro, Herrera, María, Villalta, Mauren, Vargas, Mariángela, Gutiérrez, José María, León, Guillermo

“…Purity is a characteristic that, together with effectiveness and safety, must be tested to determine the quality of biopharmaceutical products. In therapeutic…”
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Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step by Vargas, Mariángela, Segura, Álvaro, Villalta, Mauren, Herrera, María, Gutiérrez, José María, León, Guillermo

“…There is a need to introduce innovations in the manufacture of snake antivenoms to increase the supply of these products worldwide. In this work, the…”
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Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19 by León, Guillermo, Herrera, María, Vargas, Mariángela, Arguedas, Mauricio, Sánchez, Andrés, Segura, Álvaro, Gómez, Aarón, Solano, Gabriela, Corrales-Aguilar, Eugenia, Risner, Kenneth, Narayanan, Aarthi, Bailey, Charles, Villalta, Mauren, Hernández, Andrés, Sánchez, Adriana, Cordero, Daniel, Solano, Daniela, Durán, Gina, Segura, Eduardo, Cerdas, Maykel, Umaña, Deibid, Moscoso, Edwin, Estrada, Ricardo, Gutiérrez, Jairo, Méndez, Marcos, Castillo, Ana Cecilia, Sánchez, Laura, Sánchez, Ronald, Gutiérrez, José María, Díaz, Cecilia, Alape, Alberto

“…In the current global emergency due to SARS-CoV-2 outbreak, passive immunotherapy emerges as a promising treatment for COVID-19. Among animal-derived products,…”
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Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead by Gutiérrez, José María, Solano, Gabriela, Pla, Davinia, Herrera, María, Segura, Álvaro, Vargas, Mariángela, Villalta, Mauren, Sánchez, Andrés, Sanz, Libia, Lomonte, Bruno, León, Guillermo, Calvete, Juan J

“…Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of…”
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Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice by Rivel, Mario, Solano, Daniela, Herrera, María, Vargas, Mariángela, Villalta, Mauren, Segura, Álvaro, Arias, Ana Silvia, León, Guillermo, Gutiérrez, José María

“…The pathogenesis of dermonecrosis induced by the venom of the African spitting cobra Naja nigricollis was investigated in a mouse model. Intradermal injection…”
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Snake Venomics of African Spitting Cobras: Toxin Composition and Assessment of Congeneric Cross-Reactivity of the Pan-African EchiTAb-Plus-ICP Antivenom by Antivenomics and Neutralization Approaches by Petras, Daniel, Sanz, Libia, Segura, Álvaro, Herrera, María, Villalta, Mauren, Solano, Daniela, Vargas, Mariángela, León, Guillermo, Warrell, David A, Theakston, R. David G, Harrison, Robert A, Durfa, Nandul, Nasidi, Abdulsalam, Gutiérrez, José María, Calvete, Juan J

“…Venomic analysis of the venoms of Naja nigricollis, N. katiensis, N. nubiae, N. mossambica, and N. pallida revealed similar compositional trends. The high…”
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Current technology for the industrial manufacture of snake antivenoms by León, Guillermo, Vargas, Mariángela, Segura, Álvaro, Herrera, María, Villalta, Mauren, Sánchez, Andrés, Solano, Gabriela, Gómez, Aarón, Sánchez, Melvin, Estrada, Ricardo, Gutiérrez, José María

“…Snake antivenoms are formulations of animal immunoglobulins used in the treatment of snakebite envenomation. The general scheme for producing snake antivenoms…”
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Comparison of the intrageneric neutralization scope of monospecific, bispecific/monogeneric and polyspecific/monogeneric antisera raised in horses immunized with sub-Saharan African snake venoms by Sánchez, Andrés, Durán, Gina, Segura, Álvaro, Herrera, María, Vargas, Mariángela, Villalta, Mauren, Arguedas, Mauricio, Moscoso, Edwin, Umaña, Deibid, Gómez, Aarón, Gutiérrez, José María, León, Guillermo

“…Snakebite envenomation inflicts a high burden of mortality and morbidity in sub-Saharan Africa. Antivenoms are the mainstay in the therapy of envenomation, and…”
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In Vitro Tests for Assessing the Neutralizing Ability of Snake Antivenoms: Toward the 3Rs Principles by Gutiérrez, José María, Vargas, Mariángela, Segura, Álvaro, Herrera, María, Villalta, Mauren, Solano, Gabriela, Sánchez, Andrés, Herrera, Cristina, León, Guillermo

“…There is an urgent need to strengthen the implementation of the 3Rs principle (Replacement, Reduction and Refinement) in the use of experimental animals in…”
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Minipool caprylic acid fractionation of plasma using disposable equipment: a practical method to enhance immunoglobulin supply in developing countries by El-Ekiaby, Magdy, Vargas, Mariángela, Sayed, Makram, Gorgy, George, Goubran, Hadi, Radosevic, Mirjana, Burnouf, Thierry

“…Immunoglobulin G (IgG) is an essential plasma-derived medicine that is lacking in developing countries. IgG shortages leave immunodeficient patients without…”
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Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Bitis spp. and Echis spp. African snakes by Gómez, Aarón, Sánchez, Andrés, Durán, Gina, Cordero, Daniel, Segura, Álvaro, Vargas, Mariángela, Solano, Daniela, Herrera, María, Chaves-Araya, Stephanie, Villalta, Mauren, Sánchez, Melvin, Arguedas, Mauricio, Díaz, Cecilia, Gutiérrez, José María, León, Guillermo

“…Snakebite envenomation exerts a heavy toll in sub-Saharan Africa. The design and production of effective polyspecific antivenoms for this region demand a…”
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Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Naja spp. African snakes by Gómez, Aarón, Sánchez, Andrés, Durán, Gina, Villalta, Mauren, Segura, Álvaro, Vargas, Mariángela, Solano, Daniela, Herrera, María, Sánchez, Melvin, Gutiérrez, José María, León, Guillermo

“…Background Envenomations by African snakes represent a high burden in the sub-Sahara region. The design and fabrication of polyspecific antivenoms with a…”
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Neutralization, by a polyspecific antivenom, of the coagulopathy induced by the venom of Bothrops asper: Assessment by standard coagulation tests and rotational thromboelastometry in a murine model by Camacho, Erika, Ramírez-Vargas, Gabriel, Vargas, Karol, Rucavado, Alexandra, Escalante, Teresa, Vargas, Mariángela, Segura, Álvaro, Argüello, Ivette, Campos, Marlen, Guerrero, German, Méndez, Marilla Lamela, Gutiérrez, José María

“…Venom-induced consumption coagulopathy and thrombocytopenia are common and potentially severe manifestations of viperid snakebite envenoming since they…”
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Toxicological profile of medically relevant Crotalus species from Mexico and their neutralization by a Crotalus basiliscus/Bothrops asper antivenom by Sánchez, Melvin, Solano, Gabriela, Vargas, Mariángela, Reta-Mares, Francisco, Neri-Castro, Édgar, Alagón, Alejandro, Sánchez, Andrés, Villalta, Mauren, León, Guillermo, Segura, Álvaro

“…Specimens of the Crotalus genus represent a potential snakebite problem in Mexico, and despite the great number of species of Crotalus present in this country,…”
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Proteomic, toxicological and immunogenic characterization of Mexican west-coast rattlesnake (Crotalus basiliscus) venom and its immunological relatedness with the venom of Central American rattlesnake (Crotalus simus) by Segura, Álvaro, Herrera, María, Reta Mares, Francisco, Jaime, Claudia, Sánchez, Andrés, Vargas, Mariángela, Villalta, Mauren, Gómez, Aarón, Gutiérrez, José María, León, Guillermo

“…The venom of the Mexican west-coast rattlesnake (Crotalus basiliscus) was characterized for its protein composition, toxicological profile and immunogenic…”
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Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of mamba (Elapidae: Dendroaspis spp.) snakes by Gómez, Aarón, Sánchez, Andrés, Durán, Gina, Villalta, Mauren, Segura, Álvaro, Vargas, Mariángela, Herrera, María, Sánchez, Melvin, Gutiérrez, José María, León, Guillermo

“…Snakebite envenomation is a neglected tropical disease posing a high toll of mortality and morbidity in sub-Saharan Africa. Polyspecific antivenoms of broad…”
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Comparative venomics and preclinical efficacy evaluation of a monospecific Hemachatus antivenom towards sub-Saharan Africa cobra venoms by Sánchez, Andrés, Segura, Álvaro, Pla, Davinia, Munuera, José, Villalta, Mauren, Quesada-Bernat, Sarai, Chavarría, Daniel, Herrera, María, Gutiérrez, José María, León, Guillermo, Calvete, Juan J., Vargas, Mariángela

“…Cobras are the most medically important elapid snakes in Africa. The African genera Naja and Hemachatus include snakes with neurotoxic and cytotoxic venoms,…”
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An improved technique for the assessment of venom-induced haemorrhage in a murine model by Jenkins, Timothy P., Sánchez, Andrés, Segura, Álvaro, Vargas, Mariángela, Herrera, María, Stewart, Trenton K., León, Guillermo, Gutiérrez, José María

“…Haemorrhage is a common clinical manifestation in envenomings caused by bites from snakes of the family Viperidae. Therefore, knowing the haemorrhagic…”
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