Search Results - "Vargas, Marcelo"

Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models by Harlan, Benjamin A., Killoy, Kelby M., Pehar, Mariana, Liu, Liping, Auwerx, Johan, Vargas, Marcelo R.

“…Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons. Astrocytes from diverse ALS models induce motor neuron death…”
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Nicotinamide Adenine Dinucleotide (NAD + )-Dependent Signaling in Neurological Disorders by Bresque, Mariana, Esteve, Daniel, Pehar, Mariana, Vargas, Marcelo R

“…Nicotinamide adenine dinucleotide (NAD ) participates in redox reactions and NAD -dependent signaling processes, which couples the enzymatic degradation of NAD…”
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Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration by Pehar, Mariana, Harlan, Benjamin A, Killoy, Kelby M, Vargas, Marcelo R

“…Nicotinamide adenine dinucleotide (NAD ) participates in redox reactions and NAD -dependent signaling processes, which involve the cleavage of NAD coupled to…”
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FABP7 upregulation induces a neurotoxic phenotype in astrocytes by Killoy, Kelby M., Harlan, Benjamin A., Pehar, Mariana, Vargas, Marcelo R.

“…Fatty acid binding proteins (FABPs) are key regulators of lipid metabolism, energy homeostasis, and inflammation. They participate in fatty acid metabolism by…”
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Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS‐linked mutant SOD1 by Harlan, Benjamin A., Pehar, Mariana, Killoy, Kelby M., Vargas, Marcelo R.

“…ABSTRACT Sirtuins (SIRTs) are NAD+‐dependent deacylases that play a key role in transcription, DNA repair, metabolism, and oxidative stress resistance…”
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Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model by Gan, Li, Vargas, Marcelo R, Johnson, Delinda A, Johnson, Jeffrey A

“…Alpha synuclein (SYN) is a central player in the pathogenesis of sporadic and familial Parkinson's disease (PD). SYN aggregation and oxidative stress are…”
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A balancing act: Independent and interdependent effects of board of directors and top management team gender composition on innovation by Alvarado-Vargas, Marcelo J., Lorenz, Melanie P., Hermans, Michel

“…The demographic composition of a firm's Board of Directors (BoD) and Top Management Team (TMT) has important consequences for organizational processes and…”
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Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis by Vargas, Marcelo R, Johnson, Delinda A, Sirkis, Daniel W, Messing, Albee, Johnson, Jeffrey A

“…Activation of the transcription factor Nrf2 in astrocytes coordinates the upregulation of antioxidant defenses and confers protection to neighboring neurons…”
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The Nrf2-ARE cytoprotective pathway in astrocytes by Vargas, Marcelo R, Johnson, Jeffrey A

“…The expression of phase-II detoxification and antioxidant enzymes is governed by a cis-acting regulatory element named the antioxidant response element (ARE)…”
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Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte by Chen, Pei-Chun, Vargas, Marcelo R, Pani, Amar K, Smeyne, Richard J, Johnson, Delinda A, Kan, Yuet Wai, Johnson, Jeffrey A

“…Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of…”
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Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis by Pehar, Mariana, Harlan, Benjamin A, Killoy, Kelby M, Vargas, Marcelo R

“…Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motor neurons in the spinal cord, brain stem, and motor cortex. The…”
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Extrasolar planets as a probe of modified gravity by Vargas dos Santos, Marcelo, Mota, David F.

“…We propose a new method to test modified gravity theories, taking advantage of the available data on extrasolar planets. We computed the deviations from the…”
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Enhancing NAD+ Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1) by Harlan, Benjamin A., Pehar, Mariana, Sharma, Deep R., Beeson, Gyda, Beeson, Craig C., Vargas, Marcelo R.

“…Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and NAD+-dependent signaling pathways. Although the redox reactions are critical for…”
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NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons by Killoy, Kelby M., Harlan, Benjamin A., Pehar, Mariana, Vargas, Marcelo R.

“…Nuclear receptor subfamily 1 group D member 1 (NR1D1, also known as Rev‐erbα) is a nuclear transcription factor that is part of the molecular clock encoding…”
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Nicotinamide Adenine Dinucleotide Precursor Supplementation Modulates Neurite Complexity and Survival in Motor Neurons from Amyotrophic Lateral Sclerosis Models by Hamilton, Haylee L, Akther, Mahbuba, Anis, Shaheer, Colwell, Christopher B, Vargas, Marcelo R, Pehar, Mariana

“…Increasing nicotinamide adenine dinucleotide (NAD ) availability has been proposed as a therapeutic approach to prevent neurodegeneration in amyotrophic…”
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Altered expression of clock and clock‐controlled genes in a hSOD1‐linked amyotrophic lateral sclerosis mouse model by Killoy, Kelby M., Pehar, Mariana, Harlan, Benjamin A., Vargas, Marcelo R.

“…Most physiological processes in mammals are subjected to daily oscillations that are governed by a circadian system. The circadian rhythm orchestrates…”
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Astrogliosis in Amyotrophic Lateral Sclerosis: Role and Therapeutic Potential of Astrocytes by Vargas, Marcelo R., Johnson, Jeffrey A.

“…Amyotrophic lateral sclerosis (ALS) is a fatal disorder characterized by the progressive loss of motor neurons. Although the molecular mechanism underlying…”
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Geographical diversification as a predictor of MNC reputations in their home nations by Thams, Yannick, Alvarado-Vargas, Marcelo J., Newburry, William

“…This study explores the link between geographical diversification and firms' home-nation reputations. We hypothesize a u-shaped relationship between geographic…”
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On the cosmological performance of photometrically classified supernovae with machine learning by Santos, Marcelo Vargas dos, Quartin, Miguel, Reis, Ribamar R R

“…ABSTRACT The efficient classification of different types of supernovae is one of the most important problems for observational cosmology. However,…”
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The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration by Johnson, Jeffrey A, Johnson, Delinda A, Kraft, Andrew D, Calkins, Marcus J, Jakel, Rebekah J, Vargas, Marcelo R, Chen, Pei-Chun

“…Transcriptional activation of protective genes is mediated by a cis-acting element called the antioxidant responsive element (ARE). The transcription factor…”
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