Search Results - "Vargas, Jorge L. Cueva"

Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma by Alarcon-Martinez, Luis, Shiga, Yukihiro, Villafranca-Baughman, Deborah, Belforte, Nicolas, Quintero, Heberto, Dotigny, Florence, Cueva Vargas, Jorge L, Di Polo, Adriana

“…Reduced blood flow and impaired neurovascular coupling are recognized features of glaucoma, the leading cause of irreversible blindness worldwide, but the…”
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Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation by Cueva Vargas, Jorge L, Osswald, Ingrid K, Unsain, Nicolas, Aurousseau, Mark R, Barker, Philip A, Bowie, Derek, Di Polo, Adriana

“…Loss of vision in glaucoma results from the selective death of retinal ganglion cells (RGCs). Tumor necrosis factor α (TNFα) signaling has been linked to RGC…”
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Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in Glaucoma by Chiasseu, Marius, Cueva Vargas, Jorge L, Destroismaisons, Laurie, Vande Velde, Christine, Leclerc, Nicole, Di Polo, Adriana

“…Glaucoma, the leading cause of irreversible blindness worldwide, is characterized by the selective death of retinal ganglion cells (RGCs). Ocular hypertension…”
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The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase a signaling by Vargas, Jorge L. Cueva, Belforte, Nicolas, Di Polo, Adriana

“…Abstract Glaucoma is a neurodegenerative disease and the leading cause of irreversible blindness worldwide. Vision deficits in glaucoma result from the…”
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AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma by Belforte, Nicolas, Agostinone, Jessica, Alarcon-Martinez, Luis, Villafranca-Baughman, Deborah, Dotigny, Florence, Cueva Vargas, Jorge L, Di Polo, Adriana

“…The maintenance of complex dendritic arbors and synaptic transmission are processes that require a substantial amount of energy. Bioenergetic decline is a…”
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Neurovascular dysfunction in glaucoma by Alarcon-Martinez, Luis, Shiga, Yukihiro, Villafranca-Baughman, Deborah, Cueva Vargas, Jorge L., Vidal Paredes, Isaac A., Quintero, Heberto, Fortune, Brad, Danesh-Meyer, Helen, Di Polo, Adriana

“…Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high metabolism requiring optimal provision of oxygen and nutrients to sustain…”
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Neuroinflammation in glaucoma：soluble tumor necrosis factor alpha and the connection with excitotoxic damage by Cueva Vargas, Jorge, Di Polo, Adriana

“…Inflammation is a complex and highly regulated response that occurs early after infection or injury.This process is initiated by cells of the immune system to…”
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A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice by Ito, Yoko A, Belforte, Nicolas, Cueva Vargas, Jorge L, Di Polo, Adriana

“…The use of rodent models of glaucoma has been essential to understand the molecular mechanisms that underlie the pathophysiology of this multifactorial…”
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Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells by Korecki, Andrea J., Cueva-Vargas, Jorge L., Fornes, Oriol, Agostinone, Jessica, Farkas, Rachelle A., Hickmott, Jack W., Lam, Siu Ling, Mathelier, Anthony, Zhou, Michelle, Wasserman, Wyeth W., Di Polo, Adriana, Simpson, Elizabeth M.

“…Small and cell-type restricted promoters are important tools for basic and preclinical research, and clinical delivery of gene therapies. In clinical gene…”
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Neuroinlfammation in glaucoma:soluble tumor necrosis factor alpha and the connection with excitotoxic damage by Jorge L. Cueva Vargas, Adriana Di Polo

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A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice by Ito, Yoko A., Belforte, Nicolas, Cueva Vargas, Jorge L., Di Polo, Adriana

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