Search Results - "Varga, Steven M."

The CD8 T Cell Response to Respiratory Virus Infections by Schmidt, Megan E, Varga, Steven M

“…Humans are highly susceptible to infection with respiratory viruses including respiratory syncytial virus (RSV), influenza virus, human metapneumovirus,…”
Get full text

Respiratory viruses and the inflammasome: The double-edged sword of inflammation by Waldstein, Kody A, Varga, Steven M

“…Upon direct interaction with viral particles, pro-inflammatory cytokines, or pattern/danger-associated molecular patterns (PAMPs/DAMPs), AMϕ detach from the…”
Get full text

Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity by Van Braeckel-Budimir, Natalija, Varga, Steven M., Badovinac, Vladimir P., Harty, John T.

“…Lung-resident primary memory CD8+ T cell populations (Trm) induced by a single influenza infection decline within months, rendering the host susceptible to new…”
Get full text

Topical Adenosine Inhibits Inflammation and Mucus Production in Viral Acute Rhinosinusitis by Waldstein, Kody A., Ganama, Maria, Varga, Steven M., Tilley, Stephen, Hua, Xiaoyang

“…Objective Viral acute rhinosinusitis (ARS) is the leading cause of work and school absence and antibiotic over‐prescription. There are limited treatment…”
Get full text

Use of compressed sensing to expedite high-throughput diagnostic testing for COVID-19 and beyond by Waldstein, Kody A, Yi, Jirong, Cho, Myung, Mudumbai, Raghu, Wu, Xiaodong, Varga, Steven M, Xu, Weiyu

“…The rapid spread of SARS-CoV-2 has placed a significant burden on public health systems to provide swift and accurate diagnostic testing highlighting the…”
Get full text

RSV vaccine-enhanced disease is orchestrated by the combined actions of distinct CD4 T cell subsets by Knudson, Cory J, Hartwig, Stacey M, Meyerholz, David K, Varga, Steven M

“…There is no currently licensed vaccine for respiratory syncytial virus (RSV) despite being the leading cause of lower respiratory tract infections in children…”
Get full text

Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection by Schmidt, Megan E, Knudson, Cory J, Hartwig, Stacey M, Pewe, Lecia L, Meyerholz, David K, Langlois, Ryan A, Harty, John T, Varga, Steven M

“…Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory CD8…”
Get full text

Considerations for a Respiratory Syncytial Virus Vaccine Targeting an Elderly Population by Stephens, Laura M., Varga, Steven M.

“…Respiratory syncytial virus (RSV) is most commonly associated with acute lower respiratory tract infections in infants and children. However, RSV also causes a…”
Get full text

Modulation of the host immune response by respiratory syncytial virus proteins by Schmidt, Megan E., Varga, Steven M.

“…Respiratory syncytial virus (RSV) causes severe respiratory disease in both the very young and the elderly. Nearly all individuals become infected in early…”
Get full text

Current Insights in the Development of Efficacious Vaccines Against RSV by Soto, Jorge A, Stephens, Laura M, Waldstein, Kody A, Canedo-Marroquín, Gisela, Varga, Steven M, Kalergis, Alexis M

Get full text

Function and Modulation of Type I Interferons during Respiratory Syncytial Virus Infection by Stephens, Laura M, Varga, Steven M

“…Respiratory syncytial virus (RSV) is the leading cause of lower respiratory infections in infants and young children, accounting for an estimated 3 million…”
Get full text

Limitations of Foxp3+ Treg depletion following viral infection in DEREG mice by Christiaansen, Allison F., Boggiatto, Paola M., Varga, Steven M.

“…Regulatory T cells (Tregs) play a critical role in maintaining tissue homeostasis and preventing the development of immunopathology. Depletion of REGulatory T…”
Get full text

Determining the Breadth of the Respiratory Syncytial Virus-Specific T Cell Response by McDermott, Daniel S, Knudson, Cory J, Varga, Steven M

“…Classifications Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Editorial: Orchestration of an Immune Response to Respiratory Pathogens by Varga, Steven M, Sant, Andrea J

Get full text

Depletion of alveolar macrophages ameliorates virus-induced disease following a pulmonary coronavirus infection by Hartwig, Stacey M, Holman, Kaitlyn M, Varga, Steven M

“…Coronaviruses cause respiratory disease in humans that can range from mild to severe. However, the pathogenesis of pulmonary coronavirus infections is poorly…”
Get full text

Sirolimus alters lung pathology and viral load following influenza A virus infection by Alsuwaidi, Ahmed R, George, Junu A, Almarzooqi, Saeeda, Hartwig, Stacey M, Varga, Steven M, Souid, Abdul-Kader

“…Inhibitors of mTOR, such as sirolimus, have been shown to induce thymus involution and inflammatory lung disease in mice. The latter effect supports the role…”
Get full text

Protective function and durability of mouse lymph node-resident memory CD8+ T cells by Anthony, Scott M, Van Braeckel-Budimir, Natalija, Moioffer, Steven J, van de Wall, Stephanie, Shan, Qiang, Vijay, Rahul, Sompallae, Ramakrishna, Hartwig, Stacey M, Jensen, Isaac J, Varga, Steven M, Butler, Noah S, Xue, Hai-Hui, Badovinac, Vladimir P, Harty, John T

“…Protective lung tissue-resident memory CD8 + T cells (Trm) form after influenza A virus (IAV) infection. We show that IAV infection of mice generates CD69 +…”
Get full text

Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy by Zaher, Amira, Stephens, Laura M, Miller, Ann M, Hartwig, Stacey M, Stolwijk, Jeffrey M, Petronek, Michael S, Zacharias, Zeb R, Wadas, Thaddeus J, Monga, Varun, Cullen, Joseph J, Furqan, Muhammad, Houtman, Jon C D, Varga, Steven M, Spitz, Douglas R, Allen, Bryan G

“…Pharmacological ascorbate (i.e., intravenous infusions of vitamin C reaching ~ 20 mM in plasma) is under active investigation as an adjuvant to standard of…”
Get full text

Pharmacological ascorbate improves the response to platinum-based chemotherapy in advanced stage non-small cell lung cancer by Furqan, Muhammad, Abu-Hejleh, Taher, Stephens, Laura M., Hartwig, Stacey M., Mott, Sarah L., Pulliam, Casey F., Petronek, Michael, Henrich, John B., Fath, Melissa A., Houtman, Jon C., Varga, Steven M., Bodeker, Kellie L., Bossler, Aaron D., Bellizzi, Andrew M., Zhang, Jun, Monga, Varun, Mani, Hariharasudan, Ivanovic, Marina, Smith, Brian J., Byrne, Margaret M., Zeitler, William, Wagner, Brett A., Buettner, Garry R., Cullen, Joseph J., Buatti, John M., Spitz, Douglas R., Allen, Bryan G.

“…Platinum-based chemotherapy with or without immunotherapy is the mainstay of treatment for advanced stage non-small cell lung cancer (NSCLC) lacking a…”
Get full text

504 Topical adenosine treatment inhibits inflammation and mucus production in viral acute rhinosinusitis by Hua, Xiaoyang, Waldstein, Kody A., Ganama, Maria, Varga, Steven M., Tilley, Stephen

“…OBJECTIVES/GOALS: Viral acute rhinosinusitis (ARS), a.k.a, the common cold, affects millions every year. The symptoms caused by viral ARS dramatically affect…”
Get full text