Search Results - "Varga, John J"

Bacterial Quorum Sensing Allows Graded and Bimodal Cellular Responses to Variations in Population Density by Rattray, Jennifer B, Thomas, Stephen A, Wang, Yifei, Molotkova, Evgeniya, Gurney, James, Varga, John J, Brown, Sam P

“…Quorum sensing (QS) is a mechanism of cell-cell communication that connects gene expression to environmental conditions (e.g., cell density) in many bacterial…”
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Type IV Pili and the CcpA Protein Are Needed for Maximal Biofilm Formation by the Gram-Positive Anaerobic Pathogen Clostridium perfringens by Varga, John J, Therit, Blair, Melville, Stephen B

“…The predominant organizational state of bacteria in nature is biofilms. Biofilms have been shown to increase bacterial resistance to a variety of stresses. We…”
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Comparative Metabolic Systems Analysis of Pathogenic Burkholderia by Bartell, Jennifer A, Yen, Phillip, Varga, John J, Goldberg, Joanna B, Papin, Jason A

“…Burkholderia cenocepacia and Burkholderia multivorans are opportunistic drug-resistant pathogens that account for the majority of Burkholderia cepacia complex…”
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Analysis of the Pseudomonas aeruginosa Regulon Controlled by the Sensor Kinase KinB and Sigma Factor RpoN by Damron, F. Heath, Owings, Joshua P, Okkotsu, Yuta, Varga, John J, Schurr, Jill R, Goldberg, Joanna B, Schurr, Michael J, Yu, Hongwei D

“…Alginate overproduction by Pseudomonas aeruginosa, also known as mucoidy, is associated with chronic endobronchial infections in cystic fibrosis. Alginate…”
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Antibiotics Drive Expansion of Rare Pathogens in a Chronic Infection Microbiome Model by Varga, John J, Zhao, Conan Y, Davis, Jacob D, Hao, Yiqi, Farrell, Jennifer M, Gurney, James R, Voit, Eberhard, Brown, Sam P

“…Chronic (long-lasting) infections are globally a major and rising cause of morbidity and mortality. Unlike typical acute infections, chronic infections are…”
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Type IV pili‐dependent gliding motility in the Gram‐positive pathogen Clostridium perfringens and other Clostridia by Varga, John J., Nguyen, Van, O'Brien, David K., Rodgers, Katherine, Walker, Richard A., Melville, Stephen B.

“…Summary Bacteria can swim in liquid media by flagellar rotation and can move on surfaces via gliding or twitching motility. One type of gliding motility…”
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The temporal dynamics of differential gene expression in Aspergillus fumigatus interacting with human immature dendritic cells in vitro by Morton, Charles O, Varga, John J, Hornbach, Anke, Mezger, Markus, Sennefelder, Helga, Kneitz, Susanne, Kurzai, Oliver, Krappmann, Sven, Einsele, Hermann, Nierman, William C, Rogers, Thomas R, Loeffler, Juergen

“…Dendritic cells (DC) are the most important antigen presenting cells and play a pivotal role in host immunity to infectious agents by acting as a bridge…”
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Genome sequencing and analysis of Yersina pestis KIM D27, an avirulent strain exempt from select agent regulation by Losada, Liliana, Varga, John J, Hostetler, Jessica, Radune, Diana, Kim, Maria, Durkin, Scott, Schneewind, Olaf, Nierman, William C

“…Yersinia pestis is the causative agent of the plague. Y. pestis KIM 10+ strain was passaged and selected for loss of the 102 kb pgm locus, resulting in an…”
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Draft Genome Sequence Determination for Cystic Fibrosis and Chronic Granulomatous Disease Burkholderia multivorans Isolates by Varga, John J, Losada, Liliana, Zelazny, Adrian M, Brinkac, Lauren, Harkins, Derek, Radune, Diana, Hostetler, Jessica, Sampaio, Elizabeth P, Ronning, Catherine M, Nierman, William C, Greenberg, David E, Holland, Steven M, Goldberg, Joanna B

“…Burkholderia multivorans is a Gram-negative bacterium and a member of the Burkholderia cepacia complex, which is frequently associated with respiratory…”
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Efficacy of a Pseudomonas aeruginosa serogroup O9 vaccine by Moustafa, Dina A, DiGiandomenico, Antonio, Raghuram, Vishnu, Schulman, Marc, Scarff, Jennifer M, Davis, Jr, Michael R, Varga, John J, Dean, Charles R, Goldberg, Joanna B

“…There are currently no approved vaccines against the opportunistic pathogen . Among vaccine targets, the lipopolysaccharide (LPS) O antigen of is the most…”
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Microbiome Data Enhances Predictive Models of Lung Function in People With Cystic Fibrosis by Zhao, Conan Y, Hao, Yiqi, Wang, Yifei, Varga, John J, Stecenko, Arlene A, Goldberg, Joanna B, Brown, Sam P

“…Abstract Background Microbiome sequencing has brought increasing attention to the polymicrobial context of chronic infections. However, clinical microbiology…”
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Exogenous Yersinia pestis quorum sensing molecules N-octanoyl-homoserine lactone and N-(3-oxooctanoyl)-homoserine lactone regulate the LcrV virulence factor by Gelhaus, H. Carl, Rozak, David A., Nierman, William C., Chen, Dan, Mojgan Zadeh, John J. Varga, Ulrich, Ricky L., Adamovicz, Jeffrey J.

“…LcrV is a key Yersinia pestis antigen, immune regulator, and component of the type III secretion system (T3SS). Researchers have shown that N-acyl-homoserine…”
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Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase by Owings, Joshua P., Kuiper, Emily G., Prezioso, Samantha M., Meisner, Jeffrey, Varga, John J., Zelinskaya, Natalia, Dammer, Eric B., Duong, Duc M., Seyfried, Nicholas T., Albertí, Sebastián, Conn, Graeme L., Goldberg, Joanna B.

“…Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that trimethylates elongation factor-thermo-unstable (EF-Tu) on lysine 5. Lysine 5 methylation…”
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Genotypic and phenotypic analyses of a Pseudomonas aeruginosa chronic bronchiectasis isolate reveal differences from cystic fibrosis and laboratory strains by Varga, John J, Barbier, Mariette, Mulet, Xavier, Bielecki, Piotr, Bartell, Jennifer A, Owings, Joshua P, Martinez-Ramos, Inmaculada, Hittle, Lauren E, Davis, Jr, Michael R, Damron, F Heath, Liechti, George W, Puchałka, Jacek, dos Santos, Vitor A P Martins, Ernst, Robert K, Papin, Jason A, Albertí, Sebastian, Oliver, Antonio, Goldberg, Joanna B

“…Pseudomonas aeruginosa is an environmentally ubiquitous Gram-negative bacterium and important opportunistic human pathogen, causing severe chronic respiratory…”
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Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK) by Shapiro, Justin A., Varga, John J., Parsonage, Derek, Walton, William, Redinbo, Matthew R., Ross, Larry J., White, E. Lucile, Bostwick, Robert, Wuest, William M., Claiborne, Al, Goldberg, Joanna B.

“…Antibiotics with novel mechanisms of action are desperately needed to combat the increasing rates of multidrug‐resistant infections. Bacterial pantothenate…”
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Distinct human antibody response to the biological warfare agent Burkholderia mallei by Varga, John J, Vigil, Adam, DeShazer, David, Waag, David M, Felgner, Philip, Goldberg, Joanna B

“…The genetic similarity between Burkholderia mallei (glanders) and Burkholderia pseudomallei (melioidosis) had led to the general assumption that pathogenesis…”
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Draft Genome Sequences of Burkholderia cenocepacia ET12 Lineage Strains K56-2 and BC7 by Varga, John J, Losada, Liliana, Zelazny, Adrian M, Kim, Maria, McCorrison, Jamison, Brinkac, Lauren, Sampaio, Elizabeth P, Greenberg, David E, Singh, Indresh, Heiner, Cheryl, Ashby, Meredith, Nierman, William C, Holland, Steven M, Goldberg, Joanna B

“…The Burkholderia cepacia complex (BCC) is a group of closely related bacteria that are responsible for respiratory infections in immunocompromised humans, most…”
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Type IV Pili and the CcpA Protein Are Needed for Maximal Biofilm Formation by the Gram-Positive Anaerobic Pathogen Clostridium perfrigens by VARGA, John J, THERIT, Blair, MELVILLE, Stephen B

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Distinct human antibody response to the biological warfare agent Burkholderia mallei by Adam Vigil, David M. Waag, Philip Felgner, John J. Varga, David DeShazer, Joanna B. Goldberg

“…The genetic similarity between Burkholderia mallei (glanders) and Burkholderia pseudomallei (melioidosis) had led to the general assumption that pathogenesis…”
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Type IV pili-dependent egliding motility in the Gram-positive pathogen Clostridium perfringens and other Clostridia by VARGA, John J, NGUYEN, Van, O'BRIEN, David K, RODGERS, Katherine, WALKER, Richard A, MELVILLE, Stephen B

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