Search Results - "Varela, Marina T."

Piperazine amides with desirable solubility, physicochemical and drug-like properties: Synthesis and evaluation of the anti-Trypanosoma cruzi activity by Varela, Marina T., Romanelli, Maiara, Amaral, Maiara, Tempone, Andre G., Fernandes, João Paulo S.

“…The absence of effective chronic treatment, expansion to non-endemic countries and the significant burden in public health have stimulated the search for novel…”
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Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in Trypanosoma cruzi by Amaral, Maiara, Varela, Marina T, Kant, Ravi, Christodoulides, Myron, Fernandes, João Paulo S, Tempone, Andre G

“…Chagas disease is an endemic tropical disease caused by the protozoan , which affects around 7 million people worldwide, mostly in development countries. The…”
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Investigation of Structure–Activity Relationships for Benzoyl and Cinnamoyl Piperazine/Piperidine Amides as Tyrosinase Inhibitors by Varela, Marina T., de Castro Levatti, Erica V., Tempone, Andre G., Fernandes, João Paulo S.

“…Melanin is a substance that plays important roles in several organisms. Its function as an antioxidant and metal-complexing agent makes tyrosinase, the key…”
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Esterification of p -Coumaric Acid Improves the Control over Melanoma Cell Growth by Carmo-Martins, Joana I, Gonzatti, Michelangelo B, Varela, Marina T, Sousa, Maria Eduarda P, Costa, Lucas V S, Rodrigues, Elaine Guadelupe, Fernandes, João Paulo S, Keller, Alexandre C

“…Previous studies reported that p-coumaric acid modulates melanoma growth. Because the esterification of p-coumaric acid (p-CA) enhanced its activity as an…”
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Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi by Varela, Marina T., Amaral, Maiara, Romanelli, Maiara M., de Castro Levatti, Erica V., Tempone, Andre G., Fernandes, João Paulo S.

“…Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without efficient treatment for chronic patients. Despite the efforts, no new…”
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Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A by Morais, Thiago R., Conserva, Geanne A. Alves, Varela, Marina T., Costa-Silva, Thais A., Thevenard, Fernanda, Ponci, Vitor, Fortuna, Ana, Falcão, Amílcar C., Tempone, Andre G., Fernandes, João Paulo S., Lago, João Henrique G.

“…Neolignan licarin A ( 1 ) was isolated from leaves of Nectandra oppositifolia (Lauraceae) and displayed activity against trypomastigote forms of the etiologic…”
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Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands – Functional characterization and modeling studies on H3 and H4 receptors by Corrêa, Michelle F., Balico-Silva, André L., Kiss, Dóra J., Fernandes, Gustavo A.B., Maraschin, Jhonatan C., Parreiras-e-Silva, Lucas T., Varela, Marina T., Simões, Sarah C., Bouvier, Michel, Keserű, György M., Costa-Neto, Claudio M., Fernandes, João Paulo S.

“…[Display omitted] •Allylpiperazine analogues of LINS01 compounds are potent H3 receptor antagonists.•The benzofuranyl-piperazinecarboxamide 2c is a partial…”
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Antiparasitic activity of new gibbilimbol analogues and SAR analysis through efficiency and statistical methods by Varela, Marina T., Romaneli, Maiara M., Lima, Marta L., Borborema, Samanta E.T., Tempone, Andre G., Fernandes, João P.S.

“…Chagas' disease and leishmaniasis are parasitic infections enrolled among the neglected tropical diseases, which urge for new treatments. In the search for new…”
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New alkenyl derivative from Piper malacophyllum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum by Varela, Marina T., Lima, Marta L., Galuppo, Mariana K., Tempone, Andre G., Oliveira, Alberto, Lago, João Henrique G., Fernandes, João Paulo S.

“…Alkylphenols isolated from Piper malacophyllum (Piperaceae), gibbilimbols A and B, showed interesting activity against the parasites Trypanosoma cruzi and…”
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Profiling of LINS01 compounds at human dopamine D2 and D3 receptors by Corrêa, Michelle F, Reiner, David, Fernandes, Gustavo A B, Varela, Marina T, Aranha, Cecília M S Q, Stark, Holger, Fernandes, João Paulo S

“…Histamine and dopamine neuronal pathways display interesting overlapping in the CNS, especially in the limbic areas, making them very attractive to designing…”
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Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives by Varela, Marina T., Costa-Silva, Thais A., Lago, João Henrique G., Tempone, Andre G., Fernandes, João Paulo S.

“…[Display omitted] •LINS03 are potent anti-Trypanosoma cruzi agents.•These compounds did not disrupt the plasma membrane.•Balance between lipophilicity and…”
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Gibbilimbol analogues as antiparasitic agents—Synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum by Varela, Marina T., Dias, Roberto Z., Martins, Ligia F., Ferreira, Daiane D., Tempone, Andre G., Ueno, Anderson K., Lago, João Henrique G., Fernandes, João Paulo S.

“…[Display omitted] The essential oils from leaves of Piper malacophyllum (Piperaceae) showed to be mainly composed by two alkenylphenol derivatives:…”
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Pyrazinoates as antiparasitic agents against Trypanosoma cruzi by Vasconcelos, Camilla I., Varela, Marina T., Torrecilhas, Ana C., Fernandes, João P. S.

“…This work reports a repurposing study of pyrazinoic acid (1) and methyl (2), ethyl (3) and 2‐chloroethyl (4) ester derivatives with antimycobacterial activity,…”
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Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in ITrypanosoma cruzi/I by Amaral, Maiara, Varela, Marina T, Kant, Ravi, Christodoulides, Myron, Fernandes, João Paulo S, Tempone, Andre G

“…Chagas disease is an endemic tropical disease caused by the protozoan Trypanosoma cruzi, which affects around 7 million people worldwide, mostly in development…”
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Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H 3 and H 4 receptors by Corrêa, Michelle F, Balico-Silva, André L, Kiss, Dóra J, Fernandes, Gustavo A B, Maraschin, Jhonatan C, Parreiras-E-Silva, Lucas T, Varela, Marina T, Simões, Sarah C, Bouvier, Michel, Keserű, György M, Costa-Neto, Claudio M, Fernandes, João Paulo S

“…Histamine acts through four different receptors (H R-H R), the H R and H R being the most explored in the last years as drug targets. The H R is a potential…”
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