Changes in activities of circulating MMP-2 and MMP-9 in patients suffering from heart failure in relation to gender, hypertension and treatment: a cross-sectional study

Changes in activities of circulating MMP-2 and MMP-9 in patients suffering from heart failure in relation to gender, hypertension and treatment: a cross-sectional study

Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of heart failure (HF). Our aim was to determine the activities of circulating MMP-2 and MMP-9 in patients with HF in respect of gender, comorbidities and treatment (n=51). We did not reveal any differences in circulating pro...

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Bibliographic Details
Published in:Physiological research Vol. 65 Suppl 1; pp. S149 - S152
Main Authors: Giannakos, E, Vardali, E, Bartekova, M, Fogarassyova, M, Barancik, M, Radosinska, J
Format: Journal Article
Language:English
Published: Czech Republic Institute of Physiology 01-01-2016
Subjects:
Aged
Antihypertensive Agents - therapeutic use
Cardiovascular disease
Case-Control Studies
Cross-Sectional Studies
Female
Gender
Heart failure
Heart Failure - blood
Heart Failure - complications
Humans
Hypertension
Hypertension - blood
Hypertension - complications
Hypertension - drug therapy
Male
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 9 - blood
Mens health
Middle Aged
Sex Factors
Statins
Greece
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Summary:Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of heart failure (HF). Our aim was to determine the activities of circulating MMP-2 and MMP-9 in patients with HF in respect of gender, comorbidities and treatment (n=51). We did not reveal any differences in circulating pro-MMP-2 and pro-MMP-9 activities between the patients with HF and without it. However, there was a decrease in activity of pro-MMP-2 in treated hypertensive participants versus healthy ones. In contrast, we observed increased pro-MMP-2 activity in hypertensive participants with coexistent HF versus hypertensive participants without HF. In addition, a decrease in pro-MMP-2 activity was shown in women suffering from HF versus men suffering from HF. In conclusion, potential inhibitory effect of antihypertensive treatment on pro-MMP-2 activity was found. Coexistent HF with hypertension probably reduces the inhibitory effect of antihypertensive treatment on pro-MMP-2 activity. Our data also suggest the role of potential cardioprotective factors influencing the activity of pro-MMP-2 in women.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.933412