Kinetics of humoral immune response over 17 months of COVID-19 pandemic in a large cohort of healthcare workers in Spain: the ProHEpiC-19 study

Understanding the immune response to the SARS-CoV-2 virus is critical for efficient monitoring and control strategies. The ProHEpic-19 cohort provides a fine-grained description of the kinetics of antibodies after SARS-CoV-2 infection with an exceptional resolution over 17 months. We established a c...

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Published in:	BMC infectious diseases Vol. 22; no. 1; pp. 1 - 721
Main Authors:	Violán, Concepción, Torán-Monserrat, Pere, Quirant, Bibiana, Lamonja-Vicente, Noemi, Carrasco-Ribelles, Lucía A, Chacón, Carla, Manresa-Dominguez, Josep Maria, Ramos-Roure, Francesc, Dacosta-Aguayo, Rosalia, Palacios-Fernández, Cristina, Roso-Llorach, Albert, Pujol, Aleix, Ouchi, Dan, Monteagudo, Mónica, Montero-Alia, Pilar, Garcia-Sierra, Rosa, Arméstar, Fernando, Doladé, Maria, Prat, Nuria, Bonet, Josep Maria, Clotet, Bonaventura, Blanco, Ignacio, Boigues-Pons, Marc, Moreno-Millán, Nemesio, Prado, Julia G, Cáceres, Eva María Martínez, Garcia, Marta Soldevilla, Roldan, Ester Moral, Costa, Magda Alemany, Ortega, Eva Olivares, Camacho, Alba Pachón, Devesa, Marta Bujalance, Espinoza, Mariella Soto, Palma, Antonio Negrete, de San José, Mariana Martinez, Varas, Ester Lucas, Perich, Ester Badia, Rodriguez, Mónica Piéa, Graells, Elena Domenech, Gabriel, Eduard Moreno, Cintas, VictÃ²ria Sabaté, González, MÂª Jose Argerich, Duran, Asumció Vazquez, Roca, Alex Ortega, Pradells, Anna Devesa, Kielpilanen, Athina, Lombarte, Oscar Blanch, Lopez, Miguel Angel Marin, Carabelli, Julieta, Poderós, Ruth Peéa, Moyano, Esther Jimenez, Segura, Eulalia Grau, Rosa, Laia Bernard, Caballero, Raul Pérez, Lozano, Felipe Rodriguez, Rivas, Gema Fernández, Abos, Sonia Molinos, de Osaba, Jaume Barallat Martinez, Trigo, Lorena Tello, Cano, Cristina Perez, Aguilar, Juan Matllo, Martínez, Anabel López, Iglesias, Inmaculada Agüera
Format:	Journal Article
Language:	English
Published:	London BioMed Central Ltd 03-09-2022 BioMed Central BMC
Subjects:	Analysis Antibodies Asymptomatic Coronaviruses COVID-19 Data collection Decay rate Diagnosis Disease transmission Enzymes Gender Health aspects Health care Health policy IgG IgM Immune response Immune response (humoral) Immune system Immunoglobulin G Immunoglobulin M Immunology Infections Kinetics Longitudinal studies Medical personnel Nucleocapsids Pandemics Public health SARS-CoV-2 Serology Seroprevalence Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Vaccination Variables Viral diseases Viruses Spain
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Summary:	Understanding the immune response to the SARS-CoV-2 virus is critical for efficient monitoring and control strategies. The ProHEpic-19 cohort provides a fine-grained description of the kinetics of antibodies after SARS-CoV-2 infection with an exceptional resolution over 17 months. We established a cohort of 769 healthcare workers including healthy and infected with SARS-CoV-2 in northern Barcelona to determine the kinetics of the IgM against the nucleocapsid (N) and the IgG against the N and spike (S) of SARS-CoV-2 in infected healthcare workers. The study period was from 5 May 2020 to 11 November 2021.We used non-linear mixed models to investigate the kinetics of IgG and IgM measured at nine time points over 17 months from the date of diagnosis. The model included factors of time, gender, and disease severity (asymptomatic, mild-moderate, severe-critical) to assess their effects and their interactions. 474 of the 769 participants (61.6%) became infected with SARS-CoV-2. Significant effects of gender and disease severity were found for the levels of all three antibodies. Median IgM(N) levels were already below the positivity threshold in patients with asymptomatic and mild-moderate disease at day 270 after the diagnosis, while IgG(N and S) levels remained positive at least until days 450 and 270, respectively. Kinetic modelling showed a general rise in both IgM(N) and IgG(N) levels up to day 30, followed by a decay with a rate depending on disease severity. IgG(S) levels remained relatively constant from day 15 over time.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1471-2334 1471-2334
DOI:	10.1186/s12879-022-07696-6