Search Results - "Varani, Luca"

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection by Stettler, Karin, Beltramello, Martina, Espinosa, Diego A., Graham, Victoria, Cassotta, Antonino, Bianchi, Siro, Vanzetta, Fabrizia, Minola, Andrea, Jaconi, Stefano, Mele, Federico, Foglierini, Mathilde, Pedotti, Mattia, Simonelli, Luca, Dowall, Stuart, Atkinson, Barry, Percivalle, Elena, Simmons, Cameron P., Varani, Luca, Blum, Johannes, Baldanti, Fausto, Cameroni, Elisabetta, Hewson, Roger, Harris, Eva, Lanzavecchia, Antonio, Sallusto, Federica, Corti, Davide

“…Zika virus (ZIKV), a mosquito-borne flavivirus with homology to Dengue virus (DENV), has become a public health emergency. By characterizing memory lymphocytes…”
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Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia by Arcangeli, Silvia, Rotiroti, Maria Caterina, Bardelli, Marco, Simonelli, Luca, Magnani, Chiara Francesca, Biondi, Andrea, Biagi, Ettore, Tettamanti, Sarah, Varani, Luca

“…Chimeric antigen receptor (CAR)-redirected T lymphocytes are a promising immunotherapeutic approach and object of pre-clinical evaluation for the treatment of…”
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Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules by Stravalaci, Matteo, Pagani, Isabel, Paraboschi, Elvezia Maria, Pedotti, Mattia, Doni, Andrea, Scavello, Francesco, Mapelli, Sarah N., Sironi, Marina, Perucchini, Chiara, Varani, Luca, Matkovic, Milos, Cavalli, Andrea, Cesana, Daniela, Gallina, Pierangela, Pedemonte, Nicoletta, Capurro, Valeria, Clementi, Nicola, Mancini, Nicasio, Invernizzi, Pietro, Bayarri-Olmos, Rafael, Garred, Peter, Rappuoli, Rino, Duga, Stefano, Bottazzi, Barbara, Uguccioni, Mariagrazia, Asselta, Rosanna, Vicenzi, Elisa, Mantovani, Alberto, Garlanda, Cecilia

“…The humoral arm of innate immunity includes diverse molecules with antibody-like functions, some of which serve as disease severity biomarkers in coronavirus…”
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Terahertz Detection and Imaging Using Graphene Ballistic Rectifiers by Auton, Gregory, But, Dmytro B, Zhang, Jiawei, Hill, Ernie, Coquillat, Dominique, Consejo, Christophe, Nouvel, Philippe, Knap, Wojciech, Varani, Luca, Teppe, Frederic, Torres, Jeremie, Song, Aimin

“…A graphene ballistic rectifier is used in conjunction with an antenna to demonstrate a rectenna as a terahertz (THz) detector. A small-area (<1 μm2) local gate…”
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Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity by Garofalo, Maura, Piccoli, Luca, Romeo, Margherita, Barzago, Maria Monica, Ravasio, Sara, Foglierini, Mathilde, Matkovic, Milos, Sgrignani, Jacopo, De Gasparo, Raoul, Prunotto, Marco, Varani, Luca, Diomede, Luisa, Michielin, Olivier, Lanzavecchia, Antonio, Cavalli, Andrea

“…In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains (LC) form toxic aggregates and amyloid fibrils in target organs…”
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Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery by Fumagalli, Fiorenza, Noack, Julia, Bergmann, Timothy J., Cebollero, Eduardo, Pisoni, Giorgia Brambilla, Fasana, Elisa, Fregno, Ilaria, Galli, Carmela, Loi, Marisa, Soldà, Tatiana, D’Antuono, Rocco, Raimondi, Andrea, Jung, Martin, Melnyk, Armin, Schorr, Stefan, Schreiber, Anne, Simonelli, Luca, Varani, Luca, Wilson-Zbinden, Caroline, Zerbe, Oliver, Hofmann, Kay, Peter, Matthias, Quadroni, Manfredo, Zimmermann, Richard, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the…”
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Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus by Corti, Davide, Zhao, Jincun, Pedotti, Mattia, Simonelli, Luca, Agnihothram, Sudhakar, Fett, Craig, Fernandez-Rodriguez, Blanca, Foglierini, Mathilde, Agatic, Gloria, Vanzetta, Fabrizia, Gopal, Robin, Langrish, Christopher J., Barrett, Nicholas A, Sallusto, Federica, Baric, Ralph S., Varani, Luca, Zambon, Maria, Perlman, Stanley, Lanzavecchia, Antonio

“…Middle East Respiratory Syndrome (MERS) is a highly lethal pulmonary infection caused by a previously unidentified coronavirus (CoV), likely transmitted to…”
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Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release by Venereau, Emilie, Casalgrandi, Maura, Schiraldi, Milena, Antoine, Daniel J, Cattaneo, Angela, De Marchis, Francesco, Liu, Jaron, Antonelli, Antonella, Preti, Alessandro, Raeli, Lorenzo, Shams, Sara Samadi, Yang, Huan, Varani, Luca, Andersson, Ulf, Tracey, Kevin J, Bachi, Angela, Uguccioni, Mariagrazia, Bianchi, Marco E

“…Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1…”
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The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer by Yasinska, Inna M, Sakhnevych, Svetlana S, Pavlova, Ludmila, Teo Hansen Selnø, Anette, Teuscher Abeleira, Ana Maria, Benlaouer, Ouafa, Gonçalves Silva, Isabel, Mosimann, Marianne, Varani, Luca, Bardelli, Marco, Hussain, Rohanah, Siligardi, Giuliano, Cholewa, Dietmar, Berger, Steffen M, Gibbs, Bernhard F, Ushkaryov, Yuri A, Fasler-Kan, Elizaveta, Klenova, Elena, Sumbayev, Vadim V

“…Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the…”
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Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity by Yasinska, Inna M, Meyer, N Helge, Schlichtner, Stephanie, Hussain, Rohanah, Siligardi, Giuliano, Casely-Hayford, Maxwell, Fiedler, Walter, Wellbrock, Jasmin, Desmet, Cloe, Calzolai, Luigi, Varani, Luca, Berger, Steffen M, Raap, Ulrike, Gibbs, Bernhard F, Fasler-Kan, Elizaveta, Sumbayev, Vadim V

“…Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal malignancy. AML cells are capable of impairing the anti-cancer activities…”
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The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells by Gonçalves Silva, Isabel, Yasinska, Inna M., Sakhnevych, Svetlana S., Fiedler, Walter, Wellbrock, Jasmin, Bardelli, Marco, Varani, Luca, Hussain, Rohanah, Siligardi, Giuliano, Ceccone, Giacomo, Berger, Steffen M., Ushkaryov, Yuri A., Gibbs, Bernhard F., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.

“…Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating…”
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Humoral and cell-mediated response against SARS-CoV-2 variants elicited by mRNA vaccine BNT162b2 in healthcare workers: a longitudinal observational study by Cassaniti, Irene, Bergami, Federica, Percivalle, Elena, Gabanti, Elisa, Sammartino, Josè Camilla, Ferrari, Alessandro, Adzasehoun, Kodjo Messan Guy, Zavaglio, Federica, Zelini, Paola, Comolli, Giuditta, Sarasini, Antonella, Piralla, Antonio, Ricciardi, Alessandra, Zuccaro, Valentina, Maggi, Fabrizio, Novazzi, Federica, Simonelli, Luca, Varani, Luca, Lilleri, Daniele, Baldanti, Fausto

“…To assess the humoral and cell-mediated response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicited by the mRNA BNT162b2 vaccine in…”
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Plasma wave resonances in Graphene channels under controlled gate for high frequency applications by Mahi, AbdelHamid, Mahi, Fatima Zohra, Varani, Luca

“…Abstract Several devices based on 2D materials have become interesting for high-frequency applications especially sensors, amplifiers and modulators of…”
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Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer by Guerrini, Giuditta, Mehn, Dora, Fumagalli, Francesco, Gioria, Sabrina, Pedotti, Mattia, Simonelli, Luca, Bianchini, Filippo, Robbiani, Davide F, Varani, Luca, Calzolai, Luigi

“…Analytical ultracentrifugation (AUC) analysis shows that the SARS-CoV-2 trimeric Spike (S) protein adopts different quaternary conformations in solution. The…”
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Out-of-Equilibrium Collective Oscillation as Phonon Condensation in a Model Protein by Nardecchia, Ilaria, Torres, Jeremie, Lechelon, Mathias, Giliberti, Valeria, Ortolani, Michele, Nouvel, Philippe, Gori, Matteo, Meriguet, Yoann, Donato, Irene, Preto, Jordane, Varani, Luca, Sturgis, James, Pettini, Marco

“…We describe the activation of out-of-equilibrium collective oscillations of a macromolecule as a classical phonon condensation phenomenon. If a macromolecule…”
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Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells by Gonçalves Silva, Isabel, Gibbs, Bernhard F, Bardelli, Marco, Varani, Luca, Sumbayev, Vadim V

“…The T cell immunoglobulin and mucin domain 3 (Tim-3) is a plasma membrane-associated receptor which is involved in a variety of biological responses in human…”
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A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity by Bardelli, Marco, Frontzek, Karl, Simonelli, Luca, Hornemann, Simone, Pedotti, Mattia, Mazzola, Federica, Carta, Manfredi, Eckhardt, Valeria, D'Antuono, Rocco, Virgilio, Tommaso, González, Santiago F, Aguzzi, Adriano, Varani, Luca

“…Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies…”
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Rational engineering of the lccβ T. versicolor laccase for the mediator-less oxidation of large polycyclic aromatic hydrocarbons by Chiadò, Alessandro, Bosco, Francesca, Bardelli, Marco, Simonelli, Luca, Pedotti, Mattia, Marmo, Luca, Varani, Luca

“…[Display omitted] •Computational-assisted protein engineering of the binding pocket of laccases.•Mutants have activity increased up to ~ 300% in a broader pH…”
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Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses by Cervantes Rincón, Tomás, Kapoor, Tania, Keeffe, Jennifer R., Simonelli, Luca, Hoffmann, Hans-Heinrich, Agudelo, Marianna, Jurado, Andrea, Peace, Avery, Lee, Yu E., Gazumyan, Anna, Guidetti, Francesca, Cantergiani, Jasmine, Cena, Benedetta, Bianchini, Filippo, Tamagnini, Elia, Moro, Simone G., Svoboda, Pavel, Costa, Federico, Reis, Mitermayer G., Ko, Albert I., Fallon, Brian A., Avila-Rios, Santiago, Reyes-Téran, Gustavo, Rice, Charles M., Nussenzweig, Michel C., Bjorkman, Pamela J., Ruzek, Daniel, Varani, Luca, MacDonald, Margaret R., Robbiani, Davide F.

“…Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in…”
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The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells by Gonçalves Silva, Isabel, Rüegg, Laura, Gibbs, Bernhard F., Bardelli, Marco, Fruehwirth, Alexander, Varani, Luca, Berger, Steffen M., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.

“…The immune receptor Tim-3 is often highly expressed in human acute myeloid leukemia (AML) cells where it acts as a growth factor and inflammatory receptor…”
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