Search Results - "Varaksin, Mikhail V."

Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities by Kovalev, Igor S, Zyryanov, Grigory V, Santra, Sougata, Majee, Adinath, Varaksin, Mikhail V, Charushin, Valery N

“…Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most…”
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Triazavirin-A Novel Effective Antiviral Drug by Chupakhin, Oleg N, Rusinov, Vladimir L, Varaksin, Mikhail V, Ulomskiy, Evgeny N, Savateev, Konstantin V, Butorin, Ilya I, Du, Weijie, Sun, Zhiyong, Charushin, Valery N

“…This review outlines the data of numerous studies relating to the broad-spectrum antiviral drug Triazavirin that was launched on the Russian pharmaceutical…”
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Design and Antioxidant Properties of Bifunctional 2H-Imidazole-Derived Phenolic Compounds—A New Family of Effective Inhibitors for Oxidative Stress-Associated Destructive Processes by Gerasimova, Elena L., Gazizullina, Elena R., Borisova, Maria V., Igdisanova, Dinara I., Nikiforov, Egor A., Moseev, Timofey D., Varaksin, Mikhail V., Chupakhin, Oleg N., Charushin, Valery N., Ivanova, Alla V.

“…The synthesis of inhibitors for oxidative stress-associated destructive processes based on 2H-imidazole-derived phenolic compounds affording the bifunctional…”
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Transition metal-free oxidative and deoxygenative C–H/C–Li cross-couplings of 2H-imidazole 1-oxides with carboranyl lithium as an efficient synthetic approach to azaheterocyclic carboranes by Smyshliaeva, Lidia A, Varaksin, Mikhail V, Slepukhin, Pavel A, Chupakhin, Oleg N, Charushin, Valery N

“…The direct C–H functionalization methodology has first been applied to perform transition metal-free C–H/C–Li cross-couplings of 2H-imidazole 1-oxides with…”
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Metal-Free Eliminative C-H Arylthiolation of 2H-Imidazole N-Oxides with Thiophenols by Nikiforov, Egor A., Vaskina, Nailya F., Moseev, Timofey D., Varaksin, Mikhail V., Charushin, Valery N., Chupakhin, Oleg N.

“…A synthetic strategy based on reactions of cyclic imine oxides, namely 2H-imidazole 1-oxides, with thiophenols mediated by acetyl chloride was successfully…”
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Direct Functionalization of C(sp2)–H Bond in Nonaromatic Azaheterocycles: Palladium-Catalyzed Cross-Dehydrogenative Coupling (CDC) of 2H‑Imidazole 1‑Oxides with Pyrroles and Thiophenes by Akulov, Alexey A, Varaksin, Mikhail V, Charushin, Valery N, Chupakhin, Oleg N

“…The C­(sp2)–H bond functionalization methodology was first applied to carry out the palladium-catalyzed oxidative C–H/C–H coupling reactions of 2H-imidazole…”
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Bioactive Pyrrolo[2,1-f][1,2,4]triazines: Synthesis, Molecular Docking, In Vitro Cytotoxicity Assay and Antiviral Studies by Mochulskaya, Nataliya N., Kotovskaya, Svetlana K., Butorin, Ilya I., Varaksin, Mikhail V., Charushin, Valery N., Rusinov, Vladimir L., Esaulkova, Yana L., Slita, Alexander V., Ilyina, Polina A., Zarubaev, Vladimir V.

“…A series of 2,4-disubstituted pyrrolo[2,1-f][1,2,4]triazines containing both aryl and thienyl substituents were synthesized by exploiting the 1,3-cycloaddition…”
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Transition-Metal-Free C–H/C–Li Coupling of Nonaromatic 2H‑Imidazole 1‑Oxides with Pentafluorophenyl Lithium in the Design of Novel Fluorophores with Intramolecular Charge Transfer Effect by Moseev, Timofey D, Varaksin, Mikhail V, Gorlov, Denis A, Charushin, Valery N, Chupakhin, Oleg N

“…Methodology of nucleophilic substitution of hydrogen (SN H) was first applied for the direct modification of nonaromatic 2H-imidazoles to afford novel…”
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Rapid and sensitive determination of nitrobenzene in solutions and commercial honey samples using a screen-printed electrode modified by 1,3-/1,4-diazines by Svalova, Tatiana S., Saigushkina, Anna A., Verbitskiy, Egor V., Chistyakov, Konstantin A., Varaksin, Mikhail V., Rusinov, Gennady L., Charushin, Valery N., Kozitsina, Alisa N.

“…[Display omitted] •A 1,3/1,4-diazine’s modified SPE for NB determination in honey was prepared.•Cathodic currents of NB reduction enhanced the diazine-modified…”
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Metal-Free C–H/C–H Coupling of 2H‑Imidazole 1‑Oxides with Polyphenols toward Imidazole-Linked Polyphenolic Compounds by Moseev, Timofey D, Nikiforov, Egor A, Varaksin, Mikhail V, Charushin, Valery N, Chupakhin, Oleg N

“…The methodology of nucleophilic substitution of hydrogen (SN H) was successfully applied as a convenient synthetic tool to afford azaheterocyclic derivatives…”
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Synthesis, characterization, and in vitro assessment of cytotoxicity for novel azaheterocyclic nido-carboranes – Candidates in agents for boron neutron capture therapy (BNCT) of cancer by Varaksin, Mikhail V., Smyshliaeva, Lidia A., Rusinov, Vladimir L., Makeev, Oleg G., Melekhin, Vsevolod V., Baldanshirieva, Alexandra D., Gubina, Olesya G., Charushin, Valery N., Chupakhin, Oleg N.

“…A series of novel water-soluble azaheterocyclic derivatives of nido-carborane bearing quinoxaline, 2H-imidazole or 1,2,4-triazine moieties were first…”
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Iodine-Catalyzed Radical C–H Amination of Nonaromatic Imidazole Oxides: Access to Cyclic α‑Aminonitrones by Akulov, Alexey A., Varaksin, Mikhail V., Nelyubina, Anna A., Tsmokaluk, Anton N., Mazhukin, Dmitrii G., Tikhonov, Alexsei Y., Charushin, Valery N., Chupakhin, Oleg N.

“…A straightforward cross-dehydrogenative coupling approach to incorporate alicyclic amino residues into the structure of model cyclic aldonitrones, 2H-imidazole…”
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Cu(I)-Catalyzed Cycloaddition of Vinylacetylene ortho-Carborane and Arylazides in the Design of 1,2,3-Triazolyl-Modified Vinylcarborane Fluorophores by Smyshliaeva, Lidia A, Varaksin, Mikhail V, Fomina, Ekaterina I, Joy, Muthipeedika N, Bakulev, Vasiliy A, Charushin, Valery N, Chupakhin, Oleg N

“…The methodology of Cu­(I)-mediated 1,3-dipolar cycloaddition was first applied in the synthesis of photoactive 1,2,3-triazolyl-modified vinylcarboranes of…”
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1,3,7-Triazapyrene-Based ortho-Carborane Fluorophores: Convenient Synthesis, Theoretical Studies, and Aggregation-Induced Emission Properties by Smyshliaeva, Lidia A, Varaksin, Mikhail V, Fomina, Ekaterina I, Medvedeva, Margarita V, Svalova, Tatiana S, Kozitsina, Alisa N, Demidov, Oleg P, Borovlev, Ivan V, Mensch, Carl, Mampuys, Pieter, Maes, Bert U. W, Charushin, Valery N, Chupakhin, Oleg N

“…A convenient transition-metal-free approach, based on nucleophilic substitution of hydrogen (SN H), for consecutive regioselective C–H functionalization of…”
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2,7-Diazapyrenes: a brief review on synthetic strategies and application opportunities by Mukherjee, Anindita, Akulov, Alexey A, Santra, Sougata, Varaksin, Mikhail V, Kim, Grigory A, Kopchuk, Dmitry S, Taniya, Olga S, Zyryanov, Grigory V, Chupakhin, Oleg. N

“…2,7-Diazapyrenes are promising azaaromatic scaffolds with a unique structural geometry and supramolecular properties. This core moiety and its derivatives with…”
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Synthesis of Functionalized Pyrazin-2(1H)‑ones via Tele-Nucleophilic Substitution of Hydrogen Involving Grignard Reactants and Electrophiles by Mampuys, Pieter, Moseev, Timofey D, Varaksin, Mikhail V, De Houwer, Johan, Vande Velde, Christophe M. L, Chupakhin, Oleg N, Charushin, Valery N, Maes, Bert U. W

“…The reaction of 6-chloro-1-methylpyrazin-2­(1H)-one with Grignard reactants followed by quenching with different electrophiles gave access to a variety of…”
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Meso -functionalization of calix[4]arene with 1,3,7-triazapyrene in the design of novel fluorophores with the dual target detection of Al 3+ and Fe 3+ cations by Moseev, Timofey D, Lavrinchenko, Igor A, Varaksin, Mikhail V, Pobedinskaya, Diana Yu, Demidov, Oleg P, Borovlev, Ivan V, Charushin, Valery N, Chupakhin, Oleg N

“…A -functionalization strategy has successfully been applied to the synthesis of novel 1,3,7-triazapyrene derivatives of calixarenes. The key synthetic step in…”
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Blue‐Emitting 2‐Fluoroaryl‐1,2,3‐Triazole Fluorophores: Synthesis, Theoretical Calculations, and Optical Properties by Lavrinchenko, Igor A., Moseev, Timofey D., Seleznev, Yuri A., Varaksin, Mikhail V., Tsmokaluk, Anton N., Charushin, Valery N., Chupakhin, Oleg N.

“…A convenient multistep synthetic methodology to afford prospective push‐pull fluorophores based on the N(2)‐fluoroaryl‐1,2,3‐triazole scaffold as valuable…”
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The First Example of Palladium(II)-Catalyzed Oxidative C–N Cross Coupling of 2H-Imidazole 1-Oxide with Azoles by Akulov, Alexey A., Varaksin, Mikhail V., Charushin, Valery N., Chupakhin, Oleg N.

“…We report the first example of the direct nucleophilic C–H functionalization of cyclic aldonitrone, a derivative of 2 H -imidazole 1-oxide, with 1 H -imidazole…”
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Direct CH/CLi coupling of 1,2,4-triazines with C6F5Li followed by aza-Diels-Alder reaction as a pot, atom, and step economy (PASE) approach towards novel fluorinated 2,2′-bipyridine fluorophores by Moseev, Timofey D., Varaksin, Mikhail V., Gorlov, Denis A., Nikiforov, Egor A., Kopchuk, Dmitry S., Starnovskaya, Ekaterina S., Khasanov, Albert F., Zyryanov, Grigory V., Charushin, Valery N., Chupakhin, Oleg N.

“…[Display omitted] •Pot, atom, and step economy (PASE) strategy towards push-pull fluorophores.•Perfluorophenyl-modified 3-pyridyl-2-yl-1,2,4-triazines and…”
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