Search Results - "Varadi, K"

Pro- and anticoagulant factors facilitate thrombin generation and balance the haemostatic response to FEIBA® in prophylactic therapy by Varadi, K., Tangada, S., Loeschberger, M., Montsch, P., Schrenk, G., Ewenstein, B., Turecek, P. L.

“…Introduction FEIBA® consists of zymogens and traces of activated forms of procoagulant factors II, VII, IX, X, anticoagulants protein C and TFPI, and small…”
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Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors by Varadi, K, Michelfelder, S, Korff, T, Hecker, M, Trepel, M, Katus, H A, Kleinschmidt, J A, Müller, O J

“…We have demonstrated the potential of random peptide libraries displayed on adeno-associated virus (AAV)2 to select for AAV2 vectors with improved efficiency…”
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BAX 855, a PEGylated rFVIII product with prolonged half-life. Development, functional and structural characterisation by Turecek, P L, Bossard, M J, Graninger, M, Gritsch, H, Höllriegl, W, Kaliwoda, M, Matthiessen, P, Mitterer, A, Muchitsch, E-M, Purtscher, M, Rottensteiner, H, Schiviz, A, Schrenk, G, Siekmann, J, Varadi, K, Riley, T, Ehrlich, H J, Schwarz, H P, Scheiflinger, F

“…A longer acting recombinant FVIII is expected to serve patients' demand for a more convenient prophylactic therapy. We have developed BAX 855, a PEGylated form…”
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Inverse correlation of free and immune complex‐sequestered anti‐ADAMTS13 antibodies in a patient with acquired thrombotic thrombocytopenic purpura by FERRARI, S., KNÖBL, P., KOLOVRATOVA, V., PLAIMAUER, B., TURECEK, P. L., VARADI, K., ROTTENSTEINER, H., SCHEIFLINGER, F.

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Second international collaborative study evaluating performance characteristics of methods measuring the von Willebrand factor cleaving protease (ADAMTS‐13) by TRIPODI, A., PEYVANDI, F., CHANTARANGKUL, V., PALLA, R., AFRASIABI, A., CANCIANI, M. T., CHUNG, D. W., FERRARI, S., FUJIMURA, Y., KARIMI, M., KOKAME, K., KREMER HOVINGA, J. A., LÄMMLE, B., DE MEYER, S. F., PLAIMAUER, B., VANHOORELBEKE, K., VARADI, K., MANNUCCI, P. M.

“…Background: Over the last 4 years ADAMTS‐13 measurement underwent dramatic progress with newer and simpler methods. Aims: Blind evaluation of newer methods for…”
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Measurement of von Willebrand factor‐cleaving protease (ADAMTS‐13) activity in plasma: a multicenter comparison of different assay methods by Studt, J.‐D., Böhm, M., Budde, U., Girma, J‐P., Varadi, K., Lämmle, B.

“…A severely deficient ADAMTS‐13 activity (<5%) is a key laboratory finding confirming the diagnosis of thrombotic thrombocytopenic purpura (TTP), whereas a…”
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Development of a plasma- and albumin-free recombinant von Willebrand factor by Turecek, P L, Mitterer, A, Matthiessen, H P, Gritsch, H, Varadi, K, Siekmann, J, Schnecker, K, Plaimauer, B, Kaliwoda, M, Purtscher, M, Woehrer, W, Mundt, W, Muchitsch, E-M, Suiter, T, Ewenstein, B, Ehrlich, H J, Schwarz, H P

“…Baxter has developed a recombinant therapy for treating von Willebrand's disease. Recombinant VWF is co-expressed with the rFVIII in CHO cells used to produce…”
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Species‐dependent variability of ADAMTS13‐mediated proteolysis of human recombinant von Willebrand factor by VARADI, K., ROTTENSTEINER, H., VEJDA, S., WEBER, A., MUCHITSCH, E.‐M., TURECEK, P. L., EHRLICH, H. J., SCHEIFLINGER, F., SCHWARZ, H. P.

“…Background: von Willebrand factor (VWF) is composed of a series of multimers, the sizes of which are regulated by the plasma metalloprotease ADAMTS13…”
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Compression of homogeneous and graded SiC/EP rings : experimental results and FE modelling by TSOTRA, P, FRIEDRICH, K, FELHOS, D, VARADI, K

“…Functionally graded rings based on an epoxy matrix and SiC fillers were prepared and subjected to a compression test. For comparison, rings with homogeneous…”
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FEIBA®: mode of action by Turecek, P. L., Váradi, K., Gritsch, H., Schwarz, H. P.

“…FEIBA®(factor eight inhibitor bypassing activity) has a history of more than 30 years of successful use in controlling bleeding in haemophilic patients who…”
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Immunoadsorption for the treatment of a patient with severe thrombotic thrombocytopenic purpura resistant to plasma exchange: kinetics of an inhibitor of ADAMTS13 by Knöbl, P., Haas, M., Laczika, K., Varadi, K., Turecek, P. L.

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FE contact and thermal analysis of composite surfaces with different fibre orientations subjected to a sliding steel asperity by Váradi, Károly, Néder, Zoltán, Friedrich, Klaus

“…FE contact and thermal macro/micro-models have been developed to study the real contact and thermal behaviour of a fibre/matrix micro-structure under sliding…”
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Monitoring the bioavailability of FEIBA with a thrombin generation assay by Váradi, K., Negrier, C., Berntorp, E., Astermark, J., Bordet, J.‐C., Morfini, M., Linari, S., Schwarz, H. P., Turecek, P. L.

“…Background: Hemophilia A patients with inhibitors are generally treated with preparations containing activated coagulation factors to achieve hemostasis by…”
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Theoretical prediction of hysteretic rubber friction in ball on plate configuration by finite element method by Palfi, L., Goda, T., Varadi, K.

“…This paper has investigated theoretically the influence of sliding speed and temperature on the hysteretic friction in case of a smooth, reciprocating steel…”
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Influence of factor V and factor Va on APC-induced cleavage of human factor VIII by Váradi, K, Rosing, J, Tans, G, Schwarz, H P

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Evidence for Extracellular Processing of Pro-von Willebrand Factor After Infusion in Animals With and Without Severe von Willebrand Disease by Turecek, P.L., Pichler, L., Auer, W., Eder, G., Varadi, K., Mitterer, A., Mundt, W., Schlokat, U., Dorner, F., Drouet, L.O., Roussi, J., van Mourik, J.A., Schwarz, H.P.

“…Although proteolytic processing of pro-von Willebrand factor (pro-vWF) resulting in free propeptide and mature vWF is known to be initiated intracellularly,…”
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A chromogenic assay for activated protein C resistance by Váradi, K, Moritz, B, Lang, H, Bauer, K, Preston, E, Peake, I, Rivard, G E, Keil, B, Schwarz, H P

“…Resistance to activated protein C (APC) diagnosed on the basis of prolongation of clotting time in an activated partial thromboplastin time (aPTT) assay is now…”
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How bilateral iliolumbar fusion increases the stability of horizontal osteosynthesis in unstable pelvic ring injuries? by Bodzay, T., Sztrinkai, G., Gál, T., Simonovics, J., Váradi, K.

“…Objective In type C pelvic ring injuries, the operative stabilization of the posterior ring is absolutely indicated. There exist four different types of…”
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Evidence for Extracellular Processing of Pro-von Willebrand Factor After Infusion in Animals With and Without Severe von Willebrand Disease by Turecek, P.L., Pichler, L., Auer, W., Eder, G., Varadi, K., Mitterer, A., Mundt, W., Schlokat, U., Dorner, F., Drouet, L.O., Roussi, J., van Mourik, J.A., Schwarz, H.P.

“…Although proteolytic processing of pro-von Willebrand factor (pro-vWF) resulting in free propeptide and mature vWF is known to be initiated intracellularly,…”
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Viscoelastic characterization of an EPDM rubber and finite element simulation of its dry rolling friction by Felhos, D., Xu, D., Schlarb, A. K., Varadi, K., Goda, T.

“…The viscoelastic properties of an ethylene/propylene/diene rubber (EPDM) containing 30 parts per hundred parts rubber [phr] carbon black (CB) were determined…”
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