Search Results - "Varadhachary, Gauri R"

Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer by Blando, Jorge, Sharma, Anu, Higa, Maria Gisela, Zhao, Hao, Vence, Luis, Yadav, Shalini S., Kim, Jiseong, Sepulveda, Alejandro M., Sharp, Michael, Maitra, Anirban, Wargo, Jennifer, Tetzlaff, Michael, Broaddus, Russell, Katz, Matthew H. G., Varadhachary, Gauri R., Overman, Michael, Wang, Huamin, Yee, Cassian, Bernatchez, Chantale, Iacobuzio-Donahue, Christine, Basu, Sreyashi, Allison, James P., Sharma, Padmanee

“…Immune checkpoint therapy (ICT) has transformed cancer treatment in recent years; however, treatment response is not uniform across tumor types. The tumor…”
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Radiographic and Serologic Predictors of Pathologic Major Response to Preoperative Therapy for Pancreatic Cancer by Perri, Giampaolo, Prakash, Laura, Wang, Huamin, Bhosale, Priya, Varadhachary, Gauri R., Wolff, Robert, Fogelman, David, Overman, Michael, Pant, Shubham, Javle, Milind, Koay, Eugene, Herman, Joseph, Kim, Michael, Ikoma, Naruhiko, Tzeng, Ching-Wei, Lee, Jeffrey E., Katz, Matthew H. G.

“…OBJECTIVE:We sought to identify potential radiologic and serologic markers of pancreatic tumor response to therapy, using pathologic major response (pMR) as…”
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Validation of a Proposed Tumor Regression Grading Scheme for Pancreatic Ductal Adenocarcinoma After Neoadjuvant Therapy as a Prognostic Indicator for Survival by Lee, Sun Mi, Katz, Matthew H.G, Liu, Li, Sundar, Manonmani, Wang, Hua, Varadhachary, Gauri R, Wolff, Robert A, Lee, Jeffrey E, Maitra, Anirban, Fleming, Jason B, Rashid, Asif, Wang, Huamin

“…Neoadjuvant therapy has been increasingly used to treat patients with potentially resectable pancreatic ductal adenocarcinoma (PDAC). Although the College of…”
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Phase II Trial of Cetuximab, Gemcitabine, and Oxaliplatin Followed by Chemoradiation With Cetuximab for Locally Advanced (T4) Pancreatic Adenocarcinoma: Correlation of Smad4(Dpc4) Immunostaining With Pattern of Disease Progression by CRANE, Christopher H, VARADHACHARY, Gauri R, DAS, Prajnan, LEE, Jeffrey E, ABBRUZZESE, James L, WOLFF, Robert A, YORDY, John S, STAERKEL, Gregg A, JAVLE, Milind M, SAFRAN, Howard, HAQUE, Waqar, HOBBS, Bridgett D, KRISHNAN, Sunil, FLEMING, Jason B

“…This phase II trial was designed to assess the efficacy and safety of cetuximab, gemcitabine, and oxaliplatin followed by cetuximab, capecitabine, and…”
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Postoperative Chemotherapy Benefits Patients Who Received Preoperative Therapy and Pancreatectomy for Pancreatic Adenocarcinoma by Perri, Giampaolo, Prakash, Laura, Qiao, Wei, Varadhachary, Gauri R., Wolff, Robert, Fogelman, David, Overman, Michael, Pant, Shubham, Javle, Milind, Koay, Eugene J., Herman, Joseph, Kim, Michael, Ikoma, Naruhiko, Tzeng, Ching-Wei, Lee, Jeffrey E., Katz, Matthew H. G.

“…OBJECTIVE:We sought to determine whether postoperative chemotherapy after preoperative therapy and pancreatectomy for pancreatic ductal adenocarcinoma (PDAC)…”
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Preoperative Gemcitabine-Based Chemoradiation for Patients With Resectable Adenocarcinoma of the Pancreatic Head by EVANS, Douglas B, VARADHACHARY, Gauri R, CHARNSANGAVEJ, Chusilp, LANO, Elizabeth A, HO, Linus, LENZI, Renato, ABBRUZZESE, James L, WOLFF, Robert A, CRANE, Christopher H, SUN, Charlotte C, LEE, Jeffrey E, PISTERS, Peter W. T, VAUTHEY, Jean-Nicolas, HUAMIN WANG, CLEARY, Karen R, STAERKEL, Gregg A

“…We conducted a phase II trial to assess the outcomes of patients who received preoperative gemcitabine-based chemoradiation and pancreaticoduodenectomy (PD)…”
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Treatment Sequencing for Resectable Pancreatic Cancer: Influence of Early Metastases and Surgical Complications on Multimodality Therapy Completion and Survival by Tzeng, Ching-Wei D., Cao, Hop S. Tran, Lee, Jeffrey E., Pisters, Peter W. T., Varadhachary, Gauri R., Wolff, Robert A., Abbruzzese, James L., Crane, Christopher H., Evans, Douglas B., Wang, Huamin, Abbott, Daniel E., Vauthey, Jean-Nicolas, Aloia, Thomas A., Fleming, Jason B., Katz, Matthew H. G.

“…Barriers to multimodality therapy (MMT) completion among patients with resectable pancreatic adenocarcinoma include early cancer progression and postoperative…”
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Borderline Resectable Pancreatic Cancer: The Importance of This Emerging Stage of Disease by Katz, Matthew H.G., MD, Pisters, Peter W.T., MD, FACS, Evans, Douglas B., MD, FACS, Sun, Charlotte C., DrPH, MPH, Lee, Jeffrey E., MD, FACS, Fleming, Jason B., MD, FACS, Vauthey, J. Nicolas, MD, FACS, Abdalla, Eddie K., MD, FACS, Crane, Christopher H., MD, Wolff, Robert A., MD, Varadhachary, Gauri R., MD, Hwang, Rosa F., MD

“…Background Patients with borderline resectable pancreatic adenocarcinoma (PA) include those with localized disease who have tumor or patient characteristics…”
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Metastatic patterns in adenocarcinoma by Hess, Kenneth R., Varadhachary, Gauri R., Taylor, Sarah H., Wei, Wei, Raber, Martin N., Lenzi, Renato, Abbruzzese, James L.

“…BACKGROUND Unique metastatic patterns cited in the literature often arise from anecdotal clinical observations and autopsy reports. The authors analyzed…”
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Transport properties of pancreatic cancer describe gemcitabine delivery and response by Koay, Eugene J, Truty, Mark J, Cristini, Vittorio, Thomas, Ryan M, Chen, Rong, Chatterjee, Deyali, Kang, Ya'an, Bhosale, Priya R, Tamm, Eric P, Crane, Christopher H, Javle, Milind, Katz, Matthew H, Gottumukkala, Vijaya N, Rozner, Marc A, Shen, Haifa, Lee, Jeffery E, Wang, Huamin, Chen, Yuling, Plunkett, William, Abbruzzese, James L, Wolff, Robert A, Varadhachary, Gauri R, Ferrari, Mauro, Fleming, Jason B

“…The therapeutic resistance of pancreatic ductal adenocarcinoma (PDAC) is partly ascribed to ineffective delivery of chemotherapy to cancer cells. We…”
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Phase II Study of Capecitabine and Oxaliplatin for Advanced Adenocarcinoma of the Small Bowel and Ampulla of Vater by OVERMAN, Michael J, VARADHACHARY, Gauri R, KOPETZ, Scott, ADININ, Rosni, LIN, E, MORRIS, Jeffrey S, ENG, Cathy, ABBRUZZESE, James L, WOLFF, Robert A

“…Adenocarcinomas of the small bowel and ampulla of Vater represent rare cancers that have limited data regarding first-line therapy. We conducted a phase II…”
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Cancer of Unknown Primary in Adolescents and Young Adults: Clinicopathological Features, Prognostic Factors and Survival Outcomes by Raghav, Kanwal, Mhadgut, Hemendra, McQuade, Jennifer L, Lei, Xiudong, Ross, Alicia, Matamoros, Aurelio, Wang, Huamin, Overman, Michael J, Varadhachary, Gauri R

“…Cancer in adolescents and young adults (AYAs) (15-39 years) is increasingly recognized as a distinct clinical and biological entity. Cancer of unknown primary…”
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Preoperative Gemcitabine and Cisplatin Followed by Gemcitabine-Based Chemoradiation for Resectable Adenocarcinoma of the Pancreatic Head by VARADHACHARY, Gauri R, WOLFF, Robert A, LEE, Jeffrey H, ROSS, William A, TAMM, Eric P, BHOSALE, Priya R, KRISHNAN, Sunil, DAS, Prajnan, HO, Linus, XIONG, Henry, ABBRUZZESE, James L, EVANS, Douglas B, CRANE, Christopher H, SUN, Charlotte C, LEE, Jeffrey E, PISTERS, Peter W. T, VAUTHEY, Jean-Nicolas, ABDALLA, Eddie, HUAMIN WANG, STAERKEL, Gregg A

“…We conducted a phase II trial of preoperative gemcitabine and cisplatin chemotherapy in addition to chemoradiation (Gem-Cis-XRT) and pancreaticoduodenectomy…”
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Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma by Liu, Qingqing, Stewart, John, Wang, Hua, Rashid, Asif, Zhao, Jun, Katz, Matthew H, Lee, Jeffrey E, Fleming, Jason B, Maitra, Anirban, Wolff, Robert A, Varadhachary, Gauri R, Krishnan, Sunil, Wang, Huamin

“…Argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme for arginine biosynthesis, is expressed in many types of human malignancies. Recent studies…”
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Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy by Varadhachary, Gauri R, Tamm, Eric P, Abbruzzese, James L, Xiong, Henry Q, Crane, Christopher H, Wang, Huamin, Lee, Jeffrey E, Pisters, Peter W T, Evans, Douglas B, Wolff, Robert A

“…With recent advances in pancreatic imaging and surgical techniques, a distinct subset of pancreatic tumors is emerging that blurs the distinction between…”
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Molecular Profiling of Carcinoma of Unknown Primary and Correlation With Clinical Evaluation by VARADHACHARY, Gauri R, TALANTOV, Dmitri, ABBRUZZESE, James L, HAINSWORTH, John D, RABER, Martin N, MENG, Christina, HESS, Kenneth R, JATKOE, Tim, LENZI, Renato, SPIGEL, David R, YIXIN WANG, GRECO, F. Anthony

“…To evaluate the feasibility of a 10-gene reverse transcriptase polymerase chain reaction assay to identify the tissue of origin in patients with carcinoma of…”
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Impact of hypofractionated and standard fractionated chemoradiation before pancreatoduodenectomy for pancreatic ductal adenocarcinoma by Cloyd, Jordan M., Crane, Christopher H., Koay, Eugene J., Das, Prajnan, Krishnan, Sunil, Prakash, Laura, Snyder, Rebecca A., Varadhachary, Gauri R., Wolff, Robert A., Javle, Milind, Shroff, Rachna T., Fogelman, David, Overman, Michael, Wang, Huamin, Maitra, Anirban, Lee, Jeffrey E., Fleming, Jason B., Katz, Matthew H. G.

“…BACKGROUND Previous studies have suggested that preoperative chemoradiation (CRT) is associated with an improved margin‐negative resection rate among patients…”
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PIONEER-Panc: a platform trial for phase II randomized investigations of new and emerging therapies for localized pancreatic cancer by Douglas, Julia E, Liu, Suyu, Ma, Junsheng, Wolff, Robert A, Pant, Shubham, Maitra, Anirban, Tamm, Eric P, Bhosale, Priya, Katz, Matthew H G, Varadhachary, Gauri R, Koay, Eugene J

“…Personalized and effective treatments for pancreatic ductal adenocarcinoma (PDAC) continue to remain elusive. Novel clinical trial designs that enable…”
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Physical activity and exercise during preoperative pancreatic cancer treatment by Parker, Nathan H., Ngo-Huang, An, Lee, Rebecca E., O’Connor, Daniel P., Basen-Engquist, Karen M., Petzel, Maria Q.B., Wang, Xuemei, Xiao, Lianchun, Fogelman, David R., Schadler, Keri L., Simpson, Richard J., Fleming, Jason B., Lee, Jeffrey E., Varadhachary, Gauri R., Sahai, Sunil K., Katz, Matthew H.G.

“…Purpose Guidelines recommend exercise to cancer survivors, but limited data exists regarding exercise among patients undergoing preoperative cancer treatment…”
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Sarcomatoid carcinoma presenting as cancers of unknown primary: a clinicopathological portrait by Huey, Ryan W, Makawita, Shalini, Xiao, Lianchun, Matamoros, Aurelio, Estrella, Jeannelyn S, Overman, Michael J, Varadhachary, Gauri R, Raghav, Kanwal

“…Sarcomatoid carcinoma of unknown primary (SCUP) is a rare entity of either poorly differentiated carcinoma with sarcoma-like differentiation or a true mixed…”
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