Search Results - "Varadarajan, Srinivasan G"

Reverse electron flow-induced ROS production is attenuated by activation of mitochondrial Ca2+-sensitive K+ channels by Heinen, André, Aldakkak, Mohammed, Stowe, David F, Rhodes, Samhita S, Riess, Matthias L, Varadarajan, Srinivasan G, Camara, Amadou K S

“…Mitochondria generate reactive oxygen species (ROS) dependent on substrate conditions, O(2) concentration, redox state, and activity of the mitochondrial…”
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Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts by Novalija, Enis, Varadarajan, Srinivasan G, Camara, Amadou K S, An, Jianzhong, Chen, Qun, Riess, Matthias L, Hogg, Neil, Stowe, David F

“…We postulated that anesthetic preconditioning (APC) is triggered by reactive oxygen/nitrogen species (ROS/RNS). We used the isolated guinea pig heart perfused…”
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Cardiac mitochondrial preconditioning by Big Ca2+-sensitive K+ channel opening requires superoxide radical generation by Stowe, David F, Aldakkak, Mohammed, Camara, Amadou K S, Riess, Matthias L, Heinen, Andre, Varadarajan, Srinivasan G, Jiang, Ming-Tao

“…ATP-sensitive K+ channel opening in inner mitochondrial membranes protects hearts from ischemia-reperfusion (I/R) injury. Opening of the Big conductance…”
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Sevoflurane before or after ischemia improves contractile and metabolic function while reducing myoplasmic Ca(2+) loading in intact hearts by Varadarajan, Srinivasan G, An, Jianzhong, Novalija, Enis, Stowe, David F

“…Ca(2+) loading occurs during myocardial reperfusion injury. Volatile anesthetics can reduce reperfusion injury. The authors tested whether sevoflurane…”
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Sevoflurane before or after Ischemia improves contractile and metabolic function while reducing myoplasmic Ca2+ loading in intact hearts by VARADARAJAN, Srinivasan G, JIANZHONG AN, NOVALIJA, Enis, STOWE, David F

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Reduced cytosolic Ca(2+) loading and improved cardiac function after cardioplegic cold storage of guinea pig isolated hearts by Stowe, D F, Varadarajan, S G, An, J, Smart, S C

“…Hypothermia is cardioprotective, but it causes Ca(2+) loading and reduced function on rewarming. The aim was to associate changes in cytosolic Ca(2+) with…”
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Modulation of myocardial function and [Ca2+] sensitivity by moderate hypothermia in guinea pig isolated hearts by Stowe, D F, Fujita, S, An, J, Paulsen, R A, Varadarajan, S G, Smart, S C

“…Cardiac hypothermia alters contractility and intracellular Ca2+ concentration ([Ca2+]i) homeostasis. We examined how left ventricular pressure (LVP) is altered…”
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Improved Mitochondrial Bioenergetics by Anesthetic Preconditioning During and After 2 Hours of 27°C Ischemia in Isolated Hearts by An, Jianzhong, Camara, Amadou K. S, Riess, Matthias L, Rhodes, Samhita S, Varadarajan, Srinivasan G, Stowe, David F

“…We examined if sevoflurane given before cold ischemia of intact hearts (anesthetic preconditioning, APC) affords additional protection by further improving…”
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Reduced cytosolic Ca2+ loading and improved cardiac function after cardioplegic cold storage of guinea pig isolated hearts by STOWE, D. F, VARADARAJAN, S. G, JIANZHONG AN, SMART, S. C

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Na+/H+ Exchange Inhibition with Cardioplegia Reduces Cytosolic [Ca2+] and Myocardial Damage after Cold Ischemia by Camara, Amadou K. S, An, Jianzhong, Chen, Qun, Novalija, Enis, Varadarajan, Srinivasan G, Schelling, Pierre, Stowe, David F

“…Cold cardioplegia protects against reperfusion damage. Blocking Na/H exchange may be as protective as cardioplegia by improving the left ventricular pressure…”
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Inhibition of Na(+)/H(+) isoform-1 exchange protects hearts perfused after 6-hour cardioplegic cold storage by Stowe, David F, Heisner, James S, An, Jianzhong, Camara, Amadou, Varadarajan, Srinivasan G, Novalija, Enis, Chen, Qun, Schelling, Pierre

“…Cardiac ischemia-reperfusion activates Na(+)/H(+) exchange; excess Na(+) and the resulting Ca(2+) overload, through reverse Na(+)/Ca(2+) exchange, cause…”
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Cardiac mitochondrial Ca 2+ ‐dependent big K + channels are open during early reperfusion by Varadarajan, Srinivasan G, Camara, Amadou K.S., Rhodes, Samhita S., Aldakkak, Mohammed, Heisner, James S., Stowe, David F.

“…Abstract only…”
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Cardiac mitochondrial Ca2+ ‐dependent big K+ channels are open during early reperfusion by Varadarajan, Srinivasan G, Camara, Amadou K.S., Rhodes, Samhita S., Aldakkak, Mohammed, Heisner, James S., Stowe, David F.

“…Ca2+ ‐dependent “Big” conductance K+ (mBKCa) channels exist in inner mitochondrial (m) membranes of guinea pig myocytes. Our aim was to explore if mBKCa…”
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Mitochondrial Ca2+ ‐Dependent Big K+ Channels in Postconditioning of Guinea Pig Isolated Hearts by Varadarajan, Srinivasan G, Johnson, Chris S, Camara, Amadou KS, Heisner, James S, Heinen, Andre, Stowe, David F

“…Ca2+ ‐dependent “Big” conductance K+ (mBKCa) channels are believed to exist in inner mitochondrial (m) membranes of guinea pig myocytes. Our aim was to explore…”
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Mitochondrial Ca 2+ ‐Dependent Big K + Channels in Postconditioning of Guinea Pig Isolated Hearts by Varadarajan, Srinivasan G, Johnson, Chris S, Camara, Amadou KS, Heisner, James S, Heinen, Andre, Stowe, David F

“…Abstract only…”
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Na + /H + exchange inhibition protects against ischemic injury by preserving mitochondrial redox state, and by reducing mitochondrial Ca 2+ overload and ROS production by Spence, Marisha, Aldakkak, Mohammed, Heisner, James S, Stowe, David F, Rhodes, Samhita S, Varadarajan, Srinivasan G, Camara, Amadou KS

“…Abstract only…”
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Na+/H+ exchange inhibition protects against ischemic injury by preserving mitochondrial redox state, and by reducing mitochondrial Ca2+ overload and ROS production by Spence, Marisha, Aldakkak, Mohammed, Heisner, James S, Stowe, David F, Rhodes, Samhita S, Varadarajan, Srinivasan G, Camara, Amadou KS

“…Inhibition of Na+/H+ exchange (NHE) during ischemia reduces cardiac injury due to reduced Na+/Ca+ exchange coupled to inhibited NHE. We tested if NHE inhibitor…”
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Improved mitochondrial Ca2+ handling and functional recovery after ischemia reperfusion injury in hearts from old vs. young guinea pigs by Johnson, Christopher, Camara, Amadou KS, Aldakkak, Mohammed, Varadarajan, Srinivasan G, Heisner, James S, Stowe, David F, Rhodes, Samhita S

“…We hypothesized that aging‐induced oxidative damage to mitochondria would result in mitochondrial [Ca2+] (m[Ca2+]) overload, depressed contractile function,…”
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Improved mitochondrial Ca 2+ handling and functional recovery after ischemia reperfusion injury in hearts from old vs. young guinea pigs by Johnson, Christopher, Camara, Amadou KS, Aldakkak, Mohammed, Varadarajan, Srinivasan G, Heisner, James S, Stowe, David F, Rhodes, Samhita S

“…Abstract only…”
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Activation of Mitochondrial Ca 2+ Sensitive Potassium Channels Enhances Mitochondrial Reactive Oxygen Species Production by Heinen, Andre, Aldakkak, Mohammed, Camara, Amadou KS, Rhodes, Samhita S, Riess, Matthias L, Varadarajan, Srinivasan G, Stowe, David F

“…Abstract only…”
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