Search Results - "Vaque, Jose P."

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry by Feng, Xiaodong, Degese, Maria Sol, Iglesias-Bartolome, Ramiro, Vaque, Jose P., Molinolo, Alfredo A., Rodrigues, Murilo, Zaidi, M. Raza, Ksander, Bruce R., Merlino, Glenn, Sodhi, Akrit, Chen, Qianming, Gutkind, J. Silvio

“…Mutually exclusive activating mutations in the GNAQ and GNA11 oncogenes, encoding heterotrimeric Gαq family members, have been identified in ∼83% and ∼6% of…”
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PLCG1 mutations in cutaneous T-cell lymphomas by Vaqué, José P., Gómez-López, Gonzalo, Monsálvez, Verónica, Varela, Ignacio, Martínez, Nerea, Pérez, Cristina, Domínguez, Orlando, Graña, Osvaldo, Rodríguez-Peralto, José L., Rodríguez-Pinilla, Socorro M., González-Vela, Carmen, Rubio-Camarillo, Miriam, Martín-Sánchez, Esperanza, Pisano, David G., Papadavid, Evangelia, Papadaki, Theodora, Requena, Luis, García-Marco, José A., Méndez, Miriam, Provencio, Mariano, Hospital, Mercedes, Suárez-Massa, Dolores, Postigo, Concepción, San Segundo, David, López-Hoyos, Marcos, Ortiz-Romero, Pablo L., Piris, Miguel A., Sánchez-Beato, Margarita

“…Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of primary cutaneous T-cell lymphoproliferative processes, mainly composed of mycosis fungoides and…”
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Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters by GIULIANELLI, Sebastián, VAQUE, José P, SILVIO GUTKIND, J, LANARI, Claudia, SOLDATI, Rocio, WARGON, Victoria, VANZULLI, Silvia I, MARTINS, Rubén, ZEITLIN, Eduardo, MOLINOLO, Alfredo A, HELGUERO, Luisa A, LAMB, Caroline A

“…Synthetic progesterone used in contraception drugs (progestins) can promote breast cancer growth, but the mechanisms involved are unknown. Moreover, it remains…”
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Interaction between FGFR-2, STAT5, and Progesterone Receptors in Breast Cancer by CERLIANI, Juan P, GUILLARDOY, Tomás, GIULIANELLI, Sebastián, VAQUE, José P, SILVIO GUTKIND, J, VANZULLI, Silvia I, MARTINS, Rubén, ZEITLIN, Eduardo, LAMB, Caroline A, LANARI, Claudia

“…Fibroblast growth factor (FGF) receptor 2 (FGFR-2) polymorphisms have been associated with an increase in estrogen receptor and progesterone receptor…”
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A Genome-wide RNAi Screen Reveals a Trio-Regulated Rho GTPase Circuitry Transducing Mitogenic Signals Initiated by G Protein-Coupled Receptors by Vaqué, Jose P., Dorsam, Robert T., Feng, Xiaodong, Iglesias-Bartolome, Ramiro, Forsthoefel, David J., Chen, Qianming, Debant, Anne, Seeger, Mark A., Ksander, Bruce R., Teramoto, Hidemi, Gutkind, J. Silvio

“…Activating mutations in GNAQ and GNA11, encoding members of the Gαq family of G protein α subunits, are the driver oncogenes in uveal melanoma, and mutations…”
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Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells by Navascués, Joaquín, Bengoechea, Rocio, Tapia, Olga, Vaqué, José P, Lafarga, Miguel, Berciano, Maria T

“…The neuron-like UR61 cell is a stable PC12 subline that contains a mouse N-ras oncogene. Dexamethasone (Dex) treatment induces a neuron-like differentiation,…”
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Nuclear compartmentalization and dynamics of the poly(A)-binding protein nuclear 1 (PABPN1) inclusions in supraoptic neurons under physiological and osmotic stress conditions by Villagra, Nuria T., Bengoechea, Rocio, Vaqué, José P., Llorca, Javier, Berciano, Maria T., Lafarga, Miguel

“…Nuclear aggregation of the expanded polyalanine tract in the poly(A)-binding protein nuclear 1 (PABPN1) is the pathological hallmark of oculopharyngeal…”
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Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3 by Maruyama, Takashi, Li, Jun, Vaque, Jose P, Konkel, Joanne E, Wang, Weifeng, Zhang, Baojun, Zhang, Pin, Zamarron, Brian F, Yu, Dongyang, Wu, Yuntao, Zhuang, Yuan, Gutkind, J Silvio, Chen, WanJun

“…The molecular mechanisms that direct transcription of the gene encoding the transcription factor Foxp3 in CD4(+) T cells remain ill-defined. We show here that…”
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Interleukin‐21 Expression and Its Association With Proinflammatory Cytokines in Untreated Chronic Periodontitis Patients by Dutzan, Nicolás, Vernal, Rolando, Vaque, Jose P., García‐Sesnich, Jocelyn, Hernandez, Marcela, Abusleme, Loreto, Dezerega, Andrea, Gutkind, J. Silvio, Gamonal, Jorge

“…Background: Interleukin‐21 (IL‐21) controls the differentiation of T‐helper Th17 cells and induces the production of IL‐17 in this T‐cell subtype. The aim of…”
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MYC in chronic myeloid leukemia: induction of aberrant DNA synthesis and association with poor response to imatinib by Albajar, Marta, Gómez-Casares, M Teresa, Llorca, Javier, Mauleon, Itsaso, Vaqué, Jose P, Acosta, Juan C, Bermúdez, Arancha, Donato, Nicholas, Delgado, M Dolores, León, Javier

“…Untreated chronic myeloid leukemia (CML) progresses from chronic phase to blastic crisis (BC). Increased genomic instability, deregulated proliferation, and…”
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Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations by Curiel-Olmo, Soraya, Mondéjar, Rufino, Almaraz, Carmen, Mollejo, Manuela, Cereceda, Laura, Marès, Roso, Derdak, Sophia, Campos-Martín, Yolanda, Batlle, Ana, González de Villambrosía, Sonia, Gut, Marta, Blanc, Julie, Traverse-Glehen, Alexandra, Verney, Aurelie, Baseggio, Lucile, Camacho, Francisca I., Wotherspoon, Andrew, Stamatopoulos, Kostas, Xochelli, Aliki, Papadaki, Theodora, Kanellis, George, Ponzoni, Maurilio, García-Cosío, Monica, Vaqué, Jose P., Beltrán, Sergi, Gut, Ivo, Piris, Miguel Angel, Martínez, Nerea

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p73 Plays a Role in Erythroid Differentiation through GATA1 Induction by Marqués-García, Fernando, Ferrandiz, Nuria, Fernández-Alonso, Rosalía, González-Cano, Laura, Herreros-Villanueva, Marta, Rosa-Garrido, Manuel, Fernández-García, Belén, Vaque, José P., Marqués, Margarita M., Alonso, María Eugenia, Segovia, José Carlos, León, Javier, Marín, María C.

“…The TP73 gene gives rise to transactivation domain-p73 isoforms (TAp73) as well as ΔNp73 variants with a truncated N terminus. Although TAp73α and -Β proteins…”
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The role of estrogen receptor alpha in breast cancer cell proliferation mediated by progestins by Giulianelli, Sebastián, Vaqué, José P, Wargon, Victoria, Soldati, Rocío, Vanzulli, Silvia I, Martins, Rubén, Zeitlin, Eduardo, Helguero, Luisa, Lamb, Caroline, Molinolo, Alfredo A, Gutkind, J Silvio, Lanari, Claudia

“…In C4-HD murine mammary carcinomas and in human breast cancer T47D cells, we showed that medroxyprogesterone acetate (MPA) induces a nuclear physical…”
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Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors by Chiariello, Mario, Vaqué, Jose P, Crespo, Piero, Gutkind, J Silvio

“…A complex intracellular signaling network mediates the multiple biological activities of G-protein-coupled receptors (GPCRs). Among them, monomeric GTPases and…”
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Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc by Parreño, Matilde, Vaqué, Jose P, Casanova, Isolda, Frade, Pilar, Céspedes, M Virtudes, Pavón, Miguel Angel, Molins, Antoni, Camacho, Mercedes, Vila, Luis, Nomdedeu, Josep F, Mangues, Ramon, León, Javier

“…2,4,6-Triiodophenol (Bobel-24, AM-24) was originally described as a nonsteroid antiinflammatory molecule. We have synthesized three derivatives of Bobel-24…”
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Mutated JAK kinases and deregulated STAT activity are potential therapeutic targets in cutaneous T-cell lymphoma by Pérez, Cristina, González-Rincón, Julia, Onaindia, Arantza, Almaráz, Carmen, García-Díaz, Nuria, Pisonero, Helena, Curiel-Olmo, Soraya, Gómez, Sagrario, Cereceda, Laura, Madureira, Rebeca, Hospital, Mercedes, Suárez-Massa, Dolores, Rodriguez-Peralto, José L, Postigo, Concepción, Leon-Castillo, Alicia, González-Vela, Carmen, Martinez, Nerea, Ortiz-Romero, Pablo, Sánchez-Beato, Margarita, Piris, Miguel Á, Vaqué, José P

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B-cell lymphoma mutations: improving diagnostics and enabling targeted therapies by Vaque, J. P., Martinez, N., Batlle-Lopez, A., Perez, C., Montes-Moreno, S., Sanchez-Beato, M., Piris, M. A.

“…B-cell lymphomas comprise an increasing number of clinicopathological entities whose characterization has historically been based mainly on histopathological…”
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Colorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimens by Vaqué, José P, Martínez, Nerea, Varela, Ignacio, Fernández, Fidel, Mayorga, Marta, Derdak, Sophia, Beltrán, Sergi, Moreno, Thaidy, Almaraz, Carmen, De Las Heras, Gonzalo, Bayés, Mónica, Gut, Ivo, Crespo, Javier, Piris, Miguel A

“…We have performed a comparative ultrasequencing study of multiple colorectal lesions obtained simultaneously from four patients. Our data show that benign…”
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Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma by Wei, Jun S, Johansson, Peter, Chen, Li, Song, Young K, Tolman, Catherine, Li, Samuel, Hurd, Laura, Patidar, Rajesh, Wen, Xinyu, Badgett, Thomas C, Cheuk, Adam T C, Marshall, Jean-Claude, Steeg, Patricia S, Vaqué Díez, José P, Yu, Yanlin, Gutkind, J Silvio, Khan, Javed

“…Neuroblastoma is one of the most genomically heterogeneous childhood malignances studied to date, and the molecular events that occur during the course of the…”
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Myc Antagonizes Ras-mediated Growth Arrest in Leukemia Cells through the Inhibition of the Ras-ERK-p21Cip1 Pathway by Vaqué, Jose P., Navascues, Joaquin, Shiio, Yuzuru, Laiho, Marikki, Ajenjo, Nuria, Mauleon, Itsaso, Matallanas, David, Crespo, Piero, León, Javier

“…Even though RAS usually acts as a dominant transforming oncogene, in primary fibroblasts and some established cell lines Ras inhibits proliferation. This can…”
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