Search Results - "Vanzela, Emerielle C"
-
1
Taurine supplementation: involvement of cholinergic/phospholipase C and protein kinase A pathways in potentiation of insulin secretion and Ca2+ handling in mouse pancreatic islets
Published in British journal of nutrition (28-10-2010)“…Taurine (TAU) supplementation increases insulin secretion in response to high glucose concentrations in rodent islets. This effect is probably due to an…”
Get full text
Journal Article -
2
Taurine supplementation enhances nutrient-induced insulin secretion in pancreatic mice islets
Published in Diabetes/metabolism research and reviews (01-05-2009)“…Background Taurine (TAU), a naturally occurring sulfur‐containing amino acid, is found at high concentrations in plasma and mammalian tissues and regulates…”
Get full text
Journal Article -
3
Exercise increases pancreatic β‐cell viability in a model of type 1 diabetes through IL‐6 signaling
Published in The FASEB journal (01-05-2015)“…ABSTRACT Type 1 diabetes (T1D) is provoked by an autoimmune assault against pancreatic β cells. Exercise training enhances β‐cell mass in T1D. Here, we…”
Get full text
Journal Article -
4
A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes
Published in Molecular endocrinology (Baltimore, Md.) (01-01-2016)“…Activation of the transcription factor nuclear factor kappa B (NFkB) contributes to β-cell death in type 1 diabetes (T1D). Genome-wide association studies have…”
Get full text
Journal Article -
5
Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibition
Published in Journal of molecular endocrinology (01-07-2018)“…Type 1 diabetes is caused by an autoimmune assault that induces progressive beta-cell dysfunction and dead. Pro-inflammatory cytokines, such as interleukin 1…”
Get full text
Journal Article -
6
Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function
Published in The Journal of biological chemistry (15-04-2011)“…Type 2 diabetes mellitus results from the complex association of insulin resistance and pancreatic β-cell failure. Obesity is the main risk factor for type 2…”
Get full text
Journal Article -
7
Early decrease in Cx36 is associated with increased cell adhesion molecules (CAMs) junctional content in mouse pancreatic islets after short-term high-fat diet feeding
Published in Annals of anatomy (01-04-2022)“…Cell-to-cell interactions mediated by intercellular junctions (IJs) are crucial for beta-cell functioning and proper insulin secretion, however, their role in…”
Get full text
Journal Article -
8
Early onset of obesity induces reproductive deficits in female rats
Published in Physiology & behavior (20-03-2012)“…Abstract The incidence of obesity is increasing rapidly all over the world and results in numerous health detriments, including disruptions in reproduction…”
Get full text
Journal Article -
9
Diet-induced glucose homeostasis dysregulation is enhanced by taurine supplementation in ovariectomized mice
Published in Amino acids (01-04-2018)“…Low levels of estrogens are associated with obesity-related comorbidities. Mice with lower levels of estrogens are thereby more sensitive to the effects of a…”
Get full text
Journal Article -
10
Reduced insulin secretion function is associated with pancreatic islet redistribution of cell adhesion molecules (CAMs) in diabetic mice after prolonged high-fat diet
Published in Histochemistry and cell biology (01-07-2016)“…Intercellular junctions play a role in regulating islet cytoarchitecture, insulin biosynthesis and secretion. In this study, we investigated the animal…”
Get full text
Journal Article -
11
Inflammation of the hypothalamus leads to defective pancreatic islet function
Published in The Journal of biological chemistry (23-12-2016)Get full text
Journal Article -
12
Reduced AMPKα2 protein expression restores glucose‐induced insulin secretion in islets from calorie‐restricted rats
Published in International journal of experimental pathology (01-02-2016)“…Summary In a state of caloric restriction (CR), improved insulin action was associated with the activation of AMP‐activated kinase (AMPK). Here, we verified…”
Get full text
Journal Article -
13
Short-term calorie restriction improves glucose homeostasis in old rats: involvement of AMPK
Published in Applied physiology, nutrition, and metabolism (01-08-2014)“…The occurrence of metabolic disorders, such as diabetes, obesity, atherosclerosis, and hypertension, increases with age. Inappropriate food intake, when…”
Get more information
Journal Article -
14
Cholesteryl Ester Transfer Protein (CETP) expression does not affect glucose homeostasis and insulin secretion: studies in human CETP transgenic mice
Published in Lipids in health and disease (13-01-2016)“…Cholesteryl ester transfer protein (CETP) is a plasma protein that mediates the exchange of triglycerides for esterified cholesterol between HDL and…”
Get full text
Journal Article -
15
Leucine supplementation does not affect protein turnover and impairs the beneficial effects of endurance training on glucose homeostasis in healthy mice
Published in Amino acids (01-04-2015)“…Endurance exercise training as well as leucine supplementation modulates glucose homeostasis and protein turnover in mammals. Here, we analyze whether leucine…”
Get full text
Journal Article -
16
Altered glucose homeostasis and hepatic function in obese mice deficient for both kinin receptor genes
Published in PloS one (19-07-2012)“…The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and adiposity. Kinins…”
Get full text
Journal Article -
17
Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats
Published in The Journal of nutritional biochemistry (01-06-2011)“…Alterations in food intake such as caloric restriction modulate the expression of SIRT1 and SIRT4 proteins that are involved in pancreatic β-cell function…”
Get full text
Journal Article -
18
Metformin acts in the gut and induces gut-liver crosstalk
Published in Proceedings of the National Academy of Sciences - PNAS (24-01-2023)“…Metformin is the most prescribed drug for DM2, but its site and mechanism of action are still not well established. Here, we investigated the effects of…”
Get full text
Journal Article -
19
Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis
Published in Molecular human reproduction (10-12-2020)“…Abstract Offspring born to obese and diabetic mothers are prone to metabolic diseases, a phenotype that has been linked to mitochondrial dysfunction and…”
Get full text
Journal Article -
20
A20 Inhibits [beta]-Cell Apoptosis by Multiple Mechanisms and Predicts Residual [beta]-Cell Function in Type 1 Diabetes
Published in Molecular endocrinology (Baltimore, Md.) (01-01-2016)“…Activation of the transcription factor nuclear factor kappa B (NFkB) contributes to [beta]-cell death in type 1 diabetes (T1D). Genome-wide association studies…”
Get full text
Journal Article