Search Results - "Vanzela, Emerielle"

Exercise increases pancreatic β‐cell viability in a model of type 1 diabetes through IL‐6 signaling by Paula, Flavia M. M., Leite, Nayara C., Vanzela, Emerielle C., Kurauti, Mirian A., Freitas‐Dias, Ricardo, Carneiro, Everardo M., Boschero, Antonio C., Zoppi, Claudio C.

“…ABSTRACT Type 1 diabetes (T1D) is provoked by an autoimmune assault against pancreatic β cells. Exercise training enhances β‐cell mass in T1D. Here, we…”
Get full text

A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes by Fukaya, Makiko, Brorsson, Caroline A, Meyerovich, Kira, Catrysse, Leen, Delaroche, Diane, Vanzela, Emerielle C, Ortis, Fernanda, Beyaert, Rudi, Nielsen, Lotte B, Andersen, Marie L, Mortensen, Henrik B, Pociot, Flemming, van Loo, Geert, Størling, Joachim, Cardozo, Alessandra K

“…Activation of the transcription factor nuclear factor kappa B (NFkB) contributes to β-cell death in type 1 diabetes (T1D). Genome-wide association studies have…”
Get full text

Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibition by Nardelli, Tarlliza R, Vanzela, Emerielle C, Benedicto, Keli C, Brozzi, Flora, Fujita, André, Cardozo, Alessandra K, Eizirik, Décio L, Boschero, Antonio C, Ortis, Fernanda

“…Type 1 diabetes is caused by an autoimmune assault that induces progressive beta-cell dysfunction and dead. Pro-inflammatory cytokines, such as interleukin 1…”
Get full text

Inflammation of the Hypothalamus Leads to Defective Pancreatic Islet Function by Calegari, Vivian C., Torsoni, Adriana S., Vanzela, Emerielle C., Araújo, Eliana P., Morari, Joseane, Zoppi, Claudio C., Sbragia, Lourenço, Boschero, Antonio C., Velloso, Lício A.

“…Type 2 diabetes mellitus results from the complex association of insulin resistance and pancreatic β-cell failure. Obesity is the main risk factor for type 2…”
Get full text

Taurine supplementation: involvement of cholinergic/phospholipase C and protein kinase A pathways in potentiation of insulin secretion and Ca2+ handling in mouse pancreatic islets by Ribeiro, Rosane A., Vanzela, Emerielle C., Oliveira, Camila A. M., Bonfleur, Maria L., Boschero, Antonio C., Carneiro, Everardo M.

“…Taurine (TAU) supplementation increases insulin secretion in response to high glucose concentrations in rodent islets. This effect is probably due to an…”
Get full text

Early decrease in Cx36 is associated with increased cell adhesion molecules (CAMs) junctional content in mouse pancreatic islets after short-term high-fat diet feeding by Martinez, Carolina, Maschio, Daniela A., de Fontes, Camila C., Vanzela, Emerielle C., Benfato, Izabelle D., Gazarini, Marcos L., Carneiro, Everardo M., de Oliveira, Camila A.M., Collares-Buzato, Carla B., Carvalho, Carolina P.F.

“…Cell-to-cell interactions mediated by intercellular junctions (IJs) are crucial for beta-cell functioning and proper insulin secretion, however, their role in…”
Get full text

Early onset of obesity induces reproductive deficits in female rats by Sagae, Sara C, Menezes, Everson Ferreira, Bonfleur, Maria L, Vanzela, Emerielle C, Zacharias, Patrícia, Lubaczeuski, Camila, Franci, Celso R, Sanvitto, Gilberto L

“…Abstract The incidence of obesity is increasing rapidly all over the world and results in numerous health detriments, including disruptions in reproduction…”
Get full text

Diet-induced glucose homeostasis dysregulation is enhanced by taurine supplementation in ovariectomized mice by de Souza Santos, Roberta, Camargo, Rafael L., Vanzela, Emerielle C., Batista, Thiago M., Morato, Priscila N., Leite, Nayara C., Rovani, Juliana C., García-Arévalo, Marta, Clegg, Deborah J., Carneiro, Everardo M.

“…Low levels of estrogens are associated with obesity-related comorbidities. Mice with lower levels of estrogens are thereby more sensitive to the effects of a…”
Get full text

Reduced insulin secretion function is associated with pancreatic islet redistribution of cell adhesion molecules (CAMs) in diabetic mice after prolonged high-fat diet by Falcão, Viviane Tannuri F. L., Maschio, Daniela A., de Fontes, Camila Calvo, Oliveira, Ricardo B., Santos-Silva, Junia C., Almeida, Anna Carolina Soares, Vanzela, Emerielle C., Cartaxo, Maria Tereza, Carvalho, Carolina P. F., Collares-Buzato, Carla Beatriz

“…Intercellular junctions play a role in regulating islet cytoarchitecture, insulin biosynthesis and secretion. In this study, we investigated the animal…”
Get full text

Inflammation of the hypothalamus leads to defective pancreatic islet function by Calegari, Vivian C., Torsoni, Adriana S., Vanzela, Emerielle C., Araújo, Eliana P., Morari, Joseane, Zoppi, Claudio C., Sbragia, Lourenço, Boschero, Antonio C., Velloso, Lício A.

Get full text

Taurine supplementation enhances nutrient-induced insulin secretion in pancreatic mice islets by Ribeiro, Rosane A., Bonfleur, Maria L., Amaral, Andressa G., Vanzela, Emerielle C., Rocco, Silvana A., Boschero, Antonio C., Carneiro, Everardo M.

“…Background Taurine (TAU), a naturally occurring sulfur‐containing amino acid, is found at high concentrations in plasma and mammalian tissues and regulates…”
Get full text

Reduced AMPKα2 protein expression restores glucose‐induced insulin secretion in islets from calorie‐restricted rats by Amaral, Maria Esméria C., Ribeiro, Rosane A., Vanzela, Emerielle C., Barbosa‐Sampaio, Helena C.

“…Summary In a state of caloric restriction (CR), improved insulin action was associated with the activation of AMP‐activated kinase (AMPK). Here, we verified…”
Get full text

Short-term calorie restriction improves glucose homeostasis in old rats: involvement of AMPK by Pires, Rogério C, Souza, Eder E, Vanzela, Emerielle C, Ribeiro, Rosane A, Silva-Santos, Júnia C, Carneiro, Everardo M, Boschero, Antonio C, Amaral, Maria Esméria C

“…The occurrence of metabolic disorders, such as diabetes, obesity, atherosclerosis, and hypertension, increases with age. Inappropriate food intake, when…”
Get more information

Cholesteryl Ester Transfer Protein (CETP) expression does not affect glucose homeostasis and insulin secretion: studies in human CETP transgenic mice by Raposo, Helena F, Vanzela, Emerielle C, Berti, Jairo A, Oliveira, Helena C F

“…Cholesteryl ester transfer protein (CETP) is a plasma protein that mediates the exchange of triglycerides for esterified cholesterol between HDL and…”
Get full text

A Preclinical Model to Analyze the Oncological Safety of Fat Grafting in Breasts With Residual Cancer in Immunocompetent Hosts by Claro, Francisco, de Angelis, Camila, Lima, Renato Pierre, Morare, Joseane, Vanzela, Emerielle, Schiozer, Wandir Antonio, Velloso, Lício, Sarian, Luis Otavio Zanatta

Get full text

Leucine supplementation does not affect protein turnover and impairs the beneficial effects of endurance training on glucose homeostasis in healthy mice by Costa Júnior, José M., Rosa, Morgana R., Protzek, André O., de Paula, Flávia M., Ferreira, Sandra M., Rezende, Luiz F., Vanzela, Emerielle C., Zoppi, Cláudio C., Silveira, Leonardo R., Kettelhut, Isis C., Boschero, Antonio C., de Oliveira, Camila A. M., Carneiro, Everardo M.

“…Endurance exercise training as well as leucine supplementation modulates glucose homeostasis and protein turnover in mammals. Here, we analyze whether leucine…”
Get full text

Amino acid restriction increases β‐cell death under challenging conditions by Mateus Gonçalves, Luciana, Vettorazzi, Jean Franciesco, Vanzela, Emerielle Cristine, Figueiredo, Mariana Sarto, Batista, Thiago Martins, Zoppi, Claudio Cesar, Boschero, Antonio Carlos, Carneiro, Everardo Magalhães

“…Malnutrition programs metabolism, favor dysfunction of β cells. We aimed to establish an in vitro protocol of malnutrition, assessing the effect of amino acid…”
Get full text

Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats by do Amaral, Maria Esméria Corezola, Ueno, Mirian, Oliveira, Camila A.M, Borsonello, Natália C, Vanzela, Emerielle C, Ribeiro, Rosane A, Alves, Patricia L, Barbosa, Helena C, Carneiro, Everardo M, Boschero, Antonio C

“…Alterations in food intake such as caloric restriction modulate the expression of SIRT1 and SIRT4 proteins that are involved in pancreatic β-cell function…”
Get full text

miR-124a expression contributes to the monophasic pattern of insulin secretion in islets from pregnant rats submitted to a low-protein diet by de Siqueira, Kariny Cassia, de Lima, Faena Moura, Lima, Fernanda Souza, Taki, Marina Satie, da Cunha, Clarissa Felfili, de Lima Reis, Sílvia Regina, Camargo, Rafael Ludemann, Batista, Thiago Martins, Vanzela, Emerielle Cristine, Nardelli, Tarlliza Romanna, Carneiro, Everardo Magalhães, Bordin, Silvana, Ignácio-Souza, Letícia Martins, Latorraca, Márcia Queiroz

“…Purpose To evaluate the role of miR-124a in the regulation of genes involved in insulin exocytosis and its effects on the kinetics of insulin secretion in…”
Get full text

Lower expression of PKA α impairs insulin secretion in islets isolated from low-density lipoprotein receptor (LDLR−/− ) knockout mice by Bonfleur, Maria Lúcia, Ribeiro, Rosane Aparecida, Balbo, Sandra Lucinei, Vanzela, Emerielle Cristine, Carneiro, Everardo Magalhães, Franco de Oliveira, Helena Coutinho, Boschero, Antonio Carlos

“…Abstract Hypercholesterolemic low-density lipoprotein receptor knockout mice (LDLR−/− ) show normal whole-body insulin sensitivity, but impaired glucose…”
Get full text