Search Results - "Vanyai, Hannah"

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK by Ke, Francine F.S., Vanyai, Hannah K., Cowan, Angus D., Delbridge, Alex R.D., Whitehead, Lachlan, Grabow, Stephanie, Czabotar, Peter E., Voss, Anne K., Strasser, Andreas

“…Intrinsic apoptosis, reliant on BAX and BAK, has been postulated to be fundamental for morphogenesis, but its precise contribution to this process has not been…”
Get full text

CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes by White, Carl W, Caspar, Birgit, Vanyai, Hannah K, Pfleger, Kevin D G, Hill, Stephen J

“…G protein-coupled receptors are a major class of membrane receptors that mediate physiological and pathophysiological cellular signaling. Many aspects of…”
Get more information

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice by Rickard, James A, Anderton, Holly, Etemadi, Nima, Nachbur, Ueli, Darding, Maurice, Peltzer, Nieves, Lalaoui, Najoua, Lawlor, Kate E, Vanyai, Hannah, Hall, Cathrine, Bankovacki, Aleks, Gangoda, Lahiru, Wong, Wendy Wei-Lynn, Corbin, Jason, Huang, Chunzi, Mocarski, Edward S, Murphy, James M, Alexander, Warren S, Voss, Anne K, Vaux, David L, Kaiser, William J, Walczak, Henning, Silke, John

“…SHARPIN regulates immune signaling and contributes to full transcriptional activity and prevention of cell death in response to TNF in vitro. The inactivating…”
Get full text

Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway by Vanyai, Hannah K, Prin, Fabrice, Guillermin, Oriane, Marzook, Bishara, Boeing, Stefan, Howson, Alexander, Saunders, Rebecca E, Snoeks, Thomas, Howell, Michael, Mohun, Timothy J, Thompson, Barry

“…The Hippo-YAP/TAZ pathway is an important regulator of tissue growth, but can also control cell fate or tissue morphogenesis. Here, we investigate the function…”
Get full text

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth by Baell, Jonathan B., Leaver, David J., Hermans, Stefan J., Kelly, Gemma L., Brennan, Margs S., Downer, Natalie L., Nguyen, Nghi, Wichmann, Johannes, McRae, Helen M., Yang, Yuqing, Cleary, Ben, Lagiakos, H. Rachel, Mieruszynski, Stephen, Pacini, Guido, Vanyai, Hannah K., Bergamasco, Maria I., May, Rose E., Davey, Bethany K., Morgan, Kimberly J., Sealey, Andrew J., Wang, Beinan, Zamudio, Natasha, Wilcox, Stephen, Garnham, Alexandra L., Sheikh, Bilal N., Aubrey, Brandon J., Doggett, Karen, Chung, Matthew C., de Silva, Melanie, Bentley, John, Pilling, Pat, Hattarki, Meghan, Dolezal, Olan, Dennis, Matthew L., Falk, Hendrik, Ren, Bin, Charman, Susan A., White, Karen L., Rautela, Jai, Newbold, Andrea, Hawkins, Edwin D., Johnstone, Ricky W., Huntington, Nicholas D., Peat, Thomas S., Heath, Joan K., Strasser, Andreas, Parker, Michael W., Smyth, Gordon K., Street, Ian P., Monahan, Brendon J., Voss, Anne K., Thomas, Tim

“…Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function 1 . Among the genes coding for the MYST family…”
Get full text

YAP drives cutaneous squamous cell carcinoma formation and progression by Vincent-Mistiaen, Zoé, Elbediwy, Ahmed, Vanyai, Hannah, Cotton, Jennifer, Stamp, Gordon, Nye, Emma, Spencer-Dene, Bradley, Thomas, Gareth J, Mao, Junhao, Thompson, Barry

“…Squamous cell carcinoma (SCC) can progress to malignant metastatic cancer, including an aggressive subtype known as spindle cell carcinoma (spSCC). spSCC…”
Get full text

MOZ Regulates the Tbx1 Locus, and Moz Mutation Partially Phenocopies DiGeorge Syndrome by Voss, Anne K., Vanyai, Hannah K., Collin, Caitlin, Dixon, Mathew P., McLennan, Tamara J., Sheikh, Bilal N., Scambler, Peter, Thomas, Tim

“…DiGeorge syndrome, caused by a 22q11 microdeletion or mutation of the TBX1 gene, varies in severity greatly, even among monozygotic twins. Epigenetic phenomena…”
Get full text

Enigma proteins regulate YAP mechanotransduction by Elbediwy, Ahmed, Vanyai, Hannah, Diaz-de-la-Loza, Maria-Del-Carmen, Frith, David, Snijders, Ambrosius P, Thompson, Barry J

“…Human cells can sense mechanical stress acting upon integrin adhesions and respond by sending the YAP (also known as YAP1) and TAZ (also known as WWTR1)…”
Get full text

Using nanoBRET and CRISPR/Cas9 to monitor proximity to a genome-edited protein in real-time by White, Carl W., Vanyai, Hannah K., See, Heng B., Johnstone, Elizabeth K. M., Pfleger, Kevin D. G.

“…Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding G protein-coupled receptor (GPCR) function. It has been used to…”
Get full text

A citizen science model for implementing statewide educational DNA barcoding by Chiovitti, Anthony, Thorpe, Frazer, Gorman, Christopher, Cuxson, Jennifer L, Robevska, Gorjana, Szwed, Christopher, Duncan, Jacinta C, Vanyai, Hannah K, Cross, Joseph, Siemering, Kirby R, Sumner, Joanna

“…Our aim was to develop a widely available educational program in which students conducted authentic research that met the expectations of both the scientific…”
Get full text

The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver by Mah, Sophia Y Y, Vanyai, Hannah K, Yang, Yuqing, Voss, Anne K, Thomas, Tim

“…ING5 is a component of KAT6A and KAT7 histone lysine acetylation protein complexes. ING5 contains a PHD domain that binds to histone H3 lysine 4 when it is…”
Get full text

Increasing histone acetylation improves sociability and restores learning and memory in KAT6B-haploinsufficient mice by Bergamasco, Maria I, Vanyai, Hannah K, Garnham, Alexandra L, Geoghegan, Niall D, Vogel, Adam P, Eccles, Samantha, Rogers, Kelly L, Smyth, Gordon K, Blewitt, Marnie E, Hannan, Anthony J, Thomas, Tim, Voss, Anne K

“…Mutations in genes encoding chromatin modifiers are enriched among mutations causing intellectual disability. The continuing development of the brain…”
Get full text

Slc35a2 mosaic knockout impacts cortical development, dendritic arborisation, and neuronal firing by Spyrou, James, Aung, Khaing Phyu, Vanyai, Hannah, Leventer, Richard J., Maljevic, Snezana, Lockhart, Paul J., Howell, Katherine B., Reid, Christopher A.

“…Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an important cause of drug-resistant epilepsy. A significant…”
Get full text

Mesodermal expression of Moz is necessary for cardiac septum development by Vanyai, Hannah K., Thomas, Tim, Voss, Anne K.

“…Ventricular septal defects (VSDs) are the most commonly occurring congenital heart defect. They are regularly associated with complex syndromes, including…”
Get full text

MOZ directs the distal-less homeobox gene expression program during craniofacial development by Vanyai, Hannah K, Garnham, Alexandra, May, Rose E, McRae, Helen M, Collin, Caitlin, Wilcox, Stephen, Smyth, Gordon K, Thomas, Tim, Voss, Anne K

“…Oral clefts are common birth defects. Individuals with oral clefts who have identical genetic mutations regularly present with variable penetrance and…”
Get full text

ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development by Mah, Sophia Y Y, Vanyai, Hannah K, Li-Wai-Suen, Connie S N, Garnham, Alexandra L, Wynn, Jessica, Bergamasco, Maria I, Malelang, Shezlie, Wilcox, Stephen, Biben, Christine, Smyth, Gordon K, Thomas, Tim, Voss, Anne K

“…Inhibitor of growth 4 and 5 (ING4, ING5) are structurally similar chromatin-binding proteins in the KAT6A, KAT6B and KAT7 histone acetyltransferase protein…”
Get full text

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities by Grabow, Stephanie, Kueh, Andrew J., Ke, Francine, Vanyai, Hannah K., Sheikh, Bilal N., Dengler, Michael A., Chiang, William, Eccles, Samantha, Smyth, Ian M., Jones, Lynelle K., de Sauvage, Frederic J., Scott, Mark, Whitehead, Lachlan, Voss, Anne K., Strasser, Andreas

“…Apoptotic cell death removes unwanted cells and is regulated by interactions between pro-survival and pro-apoptotic members of the BCL-2 protein family. The…”
Get full text

MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development by Sheikh, Bilal N., Lee, Stanley C.W., El-Saafin, Farrah, Vanyai, Hannah K., Hu, Yifang, Pang, Swee Heng Milon, Grabow, Stephanie, Strasser, Andreas, Nutt, Stephen L., Alexander, Warren S., Smyth, Gordon K., Voss, Anne K., Thomas, Tim

“…The histone acetyltransferase MOZ (MYST3, KAT6A) is the target of recurrent chromosomal translocations fusing the MOZ gene to CBP, p300, NCOA3, or TIF2 in…”
Get full text

SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease by Tapia del Fierro, Andres, den Hamer, Bianca, Benetti, Natalia, Jansz, Natasha, Chen, Kelan, Beck, Tamara, Vanyai, Hannah, Gurzau, Alexandra D., Daxinger, Lucia, Xue, Shifeng, Ly, Thanh Thao Nguyen, Wanigasuriya, Iromi, Iminitoff, Megan, Breslin, Kelsey, Oey, Harald, Krom, Yvonne D., van der Hoorn, Dinja, Bouwman, Linde F., Johanson, Timothy M., Ritchie, Matthew E., Gouil, Quentin A., Reversade, Bruno, Prin, Fabrice, Mohun, Timothy, van der Maarel, Silvère M., McGlinn, Edwina, Murphy, James M., Keniry, Andrew, de Greef, Jessica C., Blewitt, Marnie E.

“…The interplay between 3D chromatin architecture and gene silencing is incompletely understood. Here, we report a novel point mutation in the non-canonical SMC…”
Get full text

De Novo Mutations in DENR Disrupt Neuronal Development and Link Congenital Neurological Disorders to Faulty mRNA Translation Re-initiation by Haas, Matilda A., Ngo, Linh, Li, Shan Shan, Schleich, Sibylle, Qu, Zhengdong, Vanyai, Hannah K., Cullen, Hayley D., Cardona-Alberich, Aida, Gladwyn-Ng, Ivan E., Pagnamenta, Alistair T., Taylor, Jenny C., Stewart, Helen, Kini, Usha, Duncan, Kent E., Teleman, Aurelio A., Keays, David A., Heng, Julian I.-T.

“…Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor…”
Get full text