Search Results - "Vantus, T"

Comparative characterization of experimental and calculated lipophilicity and anti-tumour activity of isochromanone derivatives by Huszár, M, Varga, A, Horváth, A, Loránd, T, Agócs, A, Idei, M, Mandl, J, Vántus, T, Kéri, G

“…Compound lipophilicity connected to ADME(T)(a) has great importance in drug development and it has to be evaluated by the generally used drug developmental…”
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Kinase Pathways in Chemoattractant-Induced Degranulation of Neutrophils: The Role of p38 Mitogen-Activated Protein Kinase Activated by Src Family Kinases by Mocsai, Attila, Jakus, Zoltan, Vantus, Tibor, Berton, Giorgio, Lowell, Clifford A, Ligeti, Erzsebet

“…The aim of the present study was to investigate the role of tyrosine phosphorylation pathways in fMLP-induced exocytosis of the different secretory…”
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A Tumor-Selective Somatostatin Analog (TT-232) with Strong in vitro and in vivo Antitumor Activity by Gy. Keri, Erchegyi, J., Horvath, A., Mezo, I., Idei, M., Vantus, T., Balogh, A., Zs. Vadasz, Gy. Bokonyi, Seprodi, J., Teplan, I., Csuka, O., Tejeda, M., Gaal, D., Zs. Szegedi, Szende, B., Roze, C., Kalthoff, H., Ullrich, A.

“…We report a series of new in vitro and in vivo data proving the selective antitumor activity of our somatostatin structural derivative, TT-232. In vitro, it…”
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The somatostatin analogue TT-232 induces apoptosis in A431 cells: Sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases by Vántus, Tibor, Kéri, György, Krivickiene, Zita, Valius, Mindaugas, Steták, Attila, Keppens, Stefaan, Csermely, Péter, Bauer, Pál I, Bökönyi, Gyöngyi, Declercq, Wim, Vandenabeele, Peter, Merlevede, Wilfried, Vandenheede, Jackie R

“…TT-232 is a somatostatin analogue containing a five-residue ring structure. The present report describes TT-232-induced signalling events in A431 cells, where…”
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JNK/SAPK Activation by Platelet-Derived Growth Factor in A431 Cells Requires Both the Phospholipase C-γ and the Phosphatidylinositol 3-Kinase Signaling Pathways of the Receptor by Assefa, Zerihun, Valius, Mindaugas, Vántus, Tibor, Agostinis, Patrizia, Merlevede, Wilfried, Vandenheede, Jackie R.

“…Wild-type or mutant βPDGF receptors were introduced into A431 cells that lack endogenous PDGF receptors. PDGF stimulates JNK1 activity in a dose- and…”
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Novel somatostatin analogs with tyrosine kinase inhibitory and antitumor activity by Kéri, G, Mezö, I, Horváth, A, Vadász, Z, Balogh, A, Idei, M, Vántus, T, Teplán, I, Mák, M, Horváth, J

“…A series of new somatostatin analogs have been developed and tested for antitumor activity. Some analogs strongly inhibited tyrosine kinase activity of human…”
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The tumor-selective somatostatin analog, TT2-32 induces a biphasic activation of phosphotyrosine phosphatase activity in human colon tumor cell line, SW620 by Vántus, T, Csermely, P, Teplán, I, Kéri, G

“…Somatostatin has been demonstrated to activate phosphotyrosine phosphatases (PTPases) in pancreatic cells. In this work we studied the effect of a…”
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Self-similarity of Mn(II)-induced trypsin activity oscillations. Experimental evidence by Vajda, T, Almási, F, Vántus, T

“…Aperiodic self-similar oscillations of trypsin activity were shown by experiments conducted in the presence of Mn2+ ion at pH 8.2 and -10 degrees C in frozen…”
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Protein kinase D: an intracellular traffic regulator on the move by Van Lint, Johan, Rykx, An, Maeda, Yusuke, Vantus, Tibor, Sturany, Sabine, Malhotra, Vivek, Vandenheede, Jackie R, Seufferlein, Thomas

“…Recent research has identified protein kinase D (PKD, also called PKCmu) as a serine/threonine kinase with potentially important roles in growth factor…”
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Protein kinase D: a family affair by Rykx, An, De Kimpe, Line, Mikhalap, Svetlana, Vantus, Tibor, Seufferlein, Thomas, Vandenheede, Jackie R., Van Lint, Johan

“…The protein kinase D family of enzymes consists of three isoforms: PKD1/PKCμ, PKD2 and PKD3/PKCν. They all share a similar architecture with regulatory…”
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Heat shock protein 90 chaperones and protein kinase D3 regulates androgen-independent prostate cancer development by Varga, A., Bátai, B., Gyulavári, P., Nguyen, M.T., Sőti, C., Vántus, T.

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2012PHeat shock protein 90 chaperones and protein kinase D3 regulates androgen-independent prostate cancer development by Varga, A, Bátai, B, Gyulavári, P, Nguyen, M T, Sőti, C, Vántus, T

“…Abstract Background Prostate cancer is the second leading cause of cancer related deaths in men worldwide. Heat Shock Protein 90 (Hsp90) is expressed in tumour…”
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2012P - Heat shock protein 90 chaperones and protein kinase D3 regulates androgen-independent prostate cancer development by Varga, A., Bátai, B., Gyulavári, P., Nguyen, M.T., Sőti, C., Vántus, T.

“…Prostate cancer is the second leading cause of cancer related deaths in men worldwide. Heat Shock Protein 90 (Hsp90) is expressed in tumour cells at high…”
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Getting to know protein kinase D by Lint, Johan Van, Rykx, An, Vantus, Tibor, Vandenheede, Jackie R.

“…The protein kinase D (PKD) enzymes represent a new family of second messenger stimulated kinases, with diacylglycerol as a prime, but not the sole, mediator of…”
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The Antitumor Somatostatin Analogue TT-232 Induces Cell Cycle Arrest through PKCδ and c-Src by Steták, Attila, Lankenau, Andreas, Vántus, Tibor, Csermely, Péter, Ullrich, Axel, Kéri, György

“…The heptapeptide TT-232 is structurally related to the hypothalamic hormone somatostatin and shows promise as an anticancer drug because of its tumor-specific…”
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Structure-activity relationship studies of novel somatostatin analogs with antitumor activity by Kéri, G, Mezô, I, Vadász, Z, Horváth, A, Idei, M, Vántus, T, Balogh, A, Bökönyi, G, Bajor, T, Teplán, I

“…A series of new somatostatin analogs were synthesized in order to study the relative importance of specific substitutions in relation to selectivity between…”
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Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing by Vántus, Tibor, Vertommen, Didier, Saelens, Xavier, Rykx, An, De Kimpe, Line, Vancauwenbergh, Sadia, Mikhalap, Svitlana, Waelkens, Etienne, Kéri, György, Seufferlein, Thomas, Vandenabeele, Peter, Rider, Mark H., Vandenheede, Jackie R., Van Lint, Johan

“…Recent studies have demonstrated the importance of protein kinase D (PKD) in cell proliferation and apoptosis. Here, we report that in vitro cleavage of…”
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Erratum to ``Identification and characterization of an auto-activating MEK kinase from bovine brain: Phosphorylation of serine-298 in the proline-rich domain of the mammalian MEKs'' [Int. J. Biochem. Cell Biol. 8/ 9 (1997) 1071–1083] by Wang, J, Vantus, T, Merlevede, W, Vandenheede, J.R

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Novel antitumor peptide hormones and their effect on signal transduction by Kéri, G, Balogh, A, Horváth, A, Mezö, I, Vadász, Z, Bökönyi, G, Bajor, T, Vántus, T, Teplán, I, Horváth, J

“…A series of novel gonadotropin releasing hormone (GnRH) and Somatostatin analogs have been developed in our laboratory and were screened for antiproliferative…”
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Identification and characterization of an auto-activating MEK kinase from bovine brain: Phosphorylation of serine-298 in the proline-rich domain of the mammalian MEKs by Wang, Jingxiong, Vantus, Tibor, Merlevede, Wilfried, Vandenheede, Jackie R.

“…Mitogen-activated protein kinase kinases (MKKs or MEKs) are dual specificity tyrosine/threonine protein kinases that are activated by phosphorylation at two…”
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