Search Results - "Vantler, M"

Key inflammatory pathways underlying vascular remodeling in pulmonary hypertension by Berghausen, E. M., Feik, L., Zierden, M., Vantler, M., Rosenkranz, S.

“…Independent of the underlying cause, pulmonary hypertension (PH) remains a devastating condition that is characterized by limited survival. Cumulating evidence…”
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1255 miR-101 IN STEATOSIS AND STEATOHEPATITIS OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) by Elfimova, N, Ommer, K, Schlattjan, M, Sowa, J.P, Wedemeyer, I, Vantler, M, Dienes, H.P, Canbay, A, Odenthal, M

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Pathobiological characterization of pulmonary hypertension associated with heart failure with preserved ejection fraction by Zimmermann, L, Mueller, R, Gnatzy-Feik, L, Berghausen, E, Zierden, M, Vantler, M, Baldus, S, Rosenkranz, S

“…Abstract Introduction Heart failure with preserved ejection fraction (HFpEF) is an age-related cardiometabolic disease associated with vascular inflammation in…”
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Inactivation of catalytic and non-catalytic PI3-kinase gamma function enhances hypoxia-induced pulmonary hypertension in mice by Gnatzy-Feik, L, Berghausen, E, Vantler, M, Mueller, R, Zierden, M, Ghigo, A, Hirsch, E, Baldus, S, Rosenkranz, S

“…Abstract   Rationale: Pulmonary hypertension (PH) is a pulmonary vascular disease characterised by chronically elevated pulmonary arterial mean pressure,…”
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Selective inhibition of the PI3K isoform p110alpha using BYL719 protects against tyrosine kinase-mediated processes in PASMCs and reduces experimental pulmonary hypertension in mice and rats by Berghausen, E, Krause, M, Feik, L, Vantler, M, Baldus, S, Rosenkranz, S

“…Abstract Rationale Pulmonary arterial hypertension (PAH) is a vascular disease characterized by chronic increases in pulmonary vascular resistance (PVR),…”
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Inactivation of catalytic and non-catalytic PI3 kinase gamma functions enhances hypoxia-induced pulmonary hypertension in mice by Gnatzy-Feik, L, Berghausen, E, Vantler, M, Mueller, R, Zierden, M, Ghigo, A, Hirsch, E, Baldus, S, Rosenkranz, S

“…Abstract Rationale Pulmonary hypertension (PH) is a pulmonary vascular disease characterised by chronically elevated pulmonary arterial mean pressure,…”
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Lack of PI 3-kinase isoform p110alpha in smooth muscle cells impairs aortic wall homoeostasis and thus promotes aortic aneurysm formation by Vantler, M, Berghausen, E, Zierden, M, Mollenhauer, M, Mehrkens, D, Adam, M, Baldus, S, Rosenkranz, S

“…Abstract Background In smooth muscle cells (SMCs), the PI 3-kinase isoform p110α mediates receptor tyrosine kinase dependent proliferation, chemotaxis and cell…”
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Haematopoietic PI3-kinase delta deficiency profoundly impairs regulatory T-cell biology and thereby protection against atherosclerosis by Zierden, M, Millarg, C, Berghausen, E.M, Feik, L, Baldus, S, Vantler, M, Rosenkranz, S

“…Abstract Introduction and purpose Atherosclerosis is a chronic inflammatory disease of arteries, critically involving leukocytes like macrophages as well as T…”
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The unexpected role of PI3-kinase gamma in pulmonary hypertension by Feik, L, Berghausen, E, Zierden, M, Hirsch, E, Baldus, S, Vantler, M, Rosenkranz, S

“…Abstract Introduction Pulmonary hypertension (PH) is a pulmonary vascular disease that is associated with unacceptably high morbidity and mortality. PH is…”
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PI 3-kinase isoform PI3Kalpha controls smooth muscle cell functionality and protects against aortic aneurysm formation by Vantler, M, Schorscher, M, Berghausen, E, Zierden, M, Wissmueller, M, Mollenhauer, M, Mehrkens, D, Adam, M, Baldus, S, Rosenkranz, S

“…Abstract Background Class I PI 3-kinase isoform PI3Kα is a lipid kinase and signals downstream of receptor tyrosine kinases. Smooth muscle cells (SMCs) lacking…”
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PI 3-kinase/AKT/FOXO1 signaling in smooth muscle cells protects against abdominal aortic aneurysm by Vantler, M, Schorscher, M, Berghausen, E M, Wong, D W L, Zhao, X, Gnatzy-Feik, L, Zierden, M, Mehrkens, D, Odenthal, M, Boor, P, Maegdefessel, L, Baldus, S, Rosenkranz, S

“…Abstract Background Abdominal aortic aneurysms (AAA) are characterized by loss of vascular smooth muscle cells (SMCs). Growth factors induce proliferation and…”
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PI3 kinase delta governs regulatory T-cell biology and thus confers protection against atherosclerosis progression in mice by Zierden, M, Berghausen, E M, Gnatzy-Feik, L, Millarg, C, Picard, F S R, Kiljan, M, Geissen, S, Polykratis, A, Zimmermann, L, Pasparakis, M, Baldus, S, Winkels, H, Vantler, M, Rosenkranz, S

“…Abstract Introduction and Purpose Atherosclerosis is a chronic inflammatory disease of arteries, critically involving innate and adaptive immune cells like…”
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Lack of PI 3-kinase isoform p110alpha impairs SMC differentiation and proliferation and promotes aortic aneurysm formation by Vantler, M, Schorscher, M, Moore, J B, Berhausen, E M, Zierden, M, Mollenhauer, M, Adam, M, Mehrkens, D, Baldus, S, Rosenkranz, S

“…Abstract Background Proliferation and phenotypic modulation of vascular smooth muscle cells (SMCs) significantly contribute to the functionality of the aortic…”
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P4146The six-transmembrane protein Stamp2 protects from hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension via actions in mononuclear cells and CXCL12 by Batool, M, Berghausen, E M, Zierden, M, Vantler, M, Baldus, S, Rosenkranz, S, Ten Freyhaus, H

“…Abstract Background The six-transmembrane protein of prostate (Stamp2) is a potent anti-inflammatory player in adipocytes and also in macrophages. Stamp2's…”
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P1938In vitro characterization of a novel PI 3-kinase inhibitor for growth factor-induced effects in pulmonary artery smooth muscle cells by Berghausen, E M, Moeller, F, Vantler, M, Hirsch, E, Baldus, S, Rosenkranz, R

“…Abstract Rationale Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling in pulmonary arterioles. Increased activation of receptor…”
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P4142PI3-kinase delta protects against atherosclerosis progression by governing regulatory T-cell biology by Zierden, M, Millarg, C, Baldus, S, Rosenkranz, S, Berghausen, E M, Vantler, M

“…Abstract Introduction and purpose Atherosclerosis is a chronic inflammatory disease of arteries and represents the main underlying cause of death worldwide…”
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Importance of smooth muscle p110alpha/AKT/FOXO1 signaling for the development of abdominal aortic aneurysm by Vantler, M, Schorscher, M, Berghausen, E M, Moore Iv, J B, Wong, D, Li, Z, Gnatzy-Feik, L, Zierden, M, Mehrkens, D, Adam, M, Sengle, G, Boor, P, Maegdefessel, L, Baldus, S, Rosenkranz, S

“…Abstract Background Abdominal aortic aneurysms (AAA) are characterized by loss of vascular smooth muscle cells (SMCs) and extracellular matrix (ECM)…”
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1208Deficiency of the six-transmembrane protein Stamp2 promotes hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension via cross-talk between macrophages and smooth muscle cells by Batool, M, Berghausen, E M, Vantler, M, Zierden, M, Baldus, S, Rosenkranz, S, Ten Freyhaus, H

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P1272PI3-kinase delta protects against atherosclerosis progression by controlling regulatory T-cell homeostasis and function by Zierden, M, Millarg, C, Berghausen, E M, Baldus, S, Vantler, M, Rosenkranz, S

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P1937Deficiency of PI 3-kinase isoform p110alpha in smooth muscle cells impairs vascular integrity and promotes aortic aneurysm formation by Vantler, M, Berghausen, E M, Zierden, M, Mollenhauer, M, Mehrkens, D, Adam, M, Baldus, S, Rosenkranz, S

“…Abstract Background The pathobiology of aortic aneurysms is characterized by vascular inflammation, extracellular matrix degeneration, and particularly by loss…”
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