Effects of aluminum ions on the mouse protein synthesis in vivo and in vitro

Impact of aluminium ions on the translation process in mice liver, kidney, skeletal muscle and heart was investigated in vivo as well as on the protein synthesis in liver cell-free translation system in vitro. We find that at early stages of intoxication the effect of aluminium ions on protein synth...

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Bibliographic Details
Published in:	Medicina (Kaunas, Lithuania) Vol. 38; no. 7; p. 738
Main Authors:	Viezeliene, Dale, Sadauskiene, Ilona, Vanseviciene, Natalija, Simonyte, Sandrita, Stapulionis, Romualdas, Ivanovas, Leonidas
Format:	Journal Article
Language:	Lithuanian
Published:	Switzerland 2002
Subjects:	Aluminum - toxicity Aluminum Compounds - administration & dosage Animals Chlorides - administration & dosage Heart - drug effects In Vitro Techniques Ions Kidney - drug effects Kidney - metabolism Lethal Dose 50 Liver - drug effects Liver - metabolism Mice Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Myocardium - metabolism Protein Biosynthesis Time Factors
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Summary:	Impact of aluminium ions on the translation process in mice liver, kidney, skeletal muscle and heart was investigated in vivo as well as on the protein synthesis in liver cell-free translation system in vitro. We find that at early stages of intoxication the effect of aluminium ions on protein synthesis in muscle tissues differs qualitatively from that one in liver or kidneys. Most noticeable aluminium-induced changes of protein synthesis in organs in vivo occur within the first 15-20 h after intoxication. We show that aluminium ions activates protein synthesis in liver and kidneys (at 8-16 h) while in skeletal muscle and heart does not. These results indirectly are supported by the data of experiments in vitro, which demonstrate that at low concentration aluminium ions activates protein synthesis in the cell-free translation system prepared from liver.
ISSN:	1010-660X