Search Results - "Vanparys, P"

ECVAM retrospective validation of in vitro micronucleus test (MNT) by Corvi, Raffaella, Albertini, Silvio, Hartung, Thomas, Hoffmann, Sebastian, Maurici, Daniela, Pfuhler, Stefan, van Benthem, Jan, Vanparys, Philippe

“…In the past decade several studies comparing the in vitro chromosome aberration test (CAT) and the in vitro micronucleus test (MNT) were performed. A high…”
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How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop by Kirkland, David, Pfuhler, Stefan, Tweats, David, Aardema, Marilyn, Corvi, Raffaella, Darroudi, Firouz, Elhajouji, Azeddine, Glatt, Hansruedi, Hastwell, Paul, Hayashi, Makoto, Kasper, Peter, Kirchner, Stephan, Lynch, Anthony, Marzin, Daniel, Maurici, Daniela, Meunier, Jean-Roc, Müller, Lutz, Nohynek, Gerhard, Parry, James, Parry, Elizabeth, Thybaud, Veronique, Tice, Ray, van Benthem, Jan, Vanparys, Philippe, White, Paul

“…Workshop participants agreed that genotoxicity tests in mammalian cells in vitro produce a remarkably high and unacceptable occurrence of irrelevant positive…”
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Prevalidation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals by Van Goethem, F., Adriaens, E., Alépée, N., Straube, F., De Wever, B., Cappadoro, M., Catoire, S., Hansen, E., Wolf, A., Vanparys, P.

“…This multicentre study aimed at evaluating the reliability (reproducibility) and relevance (predictivity) of a new commercially available human corneal…”
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Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals by Adriaens, E., Bytheway, H., De Wever, B., Eschrich, D., Guest, R., Hansen, E., Vanparys, P., Schoeters, G., Warren, N., Weltens, R., Whittingham, A., Remon, J.P.

“…A previous ‘in house’ validation study showed that the SMI assay can be used as an alternative to the in vivo Draize eye irritation test. The aim of this…”
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VITOTOX® bacterial genotoxicity and toxicity test for the rapid screening of chemicals by Verschaeve, L., Van Gompel, J., Thilemans, L., Regniers, L., Vanparys, P., van der Lelie, D.

“…The VITOTOX® test is a new bacterial genotoxicity test that was previously shown to be very rapid and sensitive. Initially only one Salmonella typhimurium…”
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Micronuclei as an index of cytogenetic damage: past, present, and future by Heddle, J A, Cimino, M C, Hayashi, M, Romagna, F, Shelby, M D, Tucker, J D, Vanparys, P, MacGregor, J T

“…The workshop was designed to present what is known about the production of micronuclei, what protocols are now accepted or proposed internationally, what new…”
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The mucosal toxicity of different benzalkonium chloride analogues evaluated with an alternative test using slugs by ADRIAENS, Els, DIERCKENS, Kristof, BAUTERS, Tiene G. M, NELIS, Hans J, VAN GOETHEM, Freddy, VANPARYS, Phillipe, REMON, Jean Paul

“…The objective of this study was to evaluate the mucosal toxicity of different benzalkonium chloride (BAC) analogues using slugs as the alternative test…”
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Improvement of the Bovine Corneal Opacity and Permeability (BCOP) assay as an in vitro alternative to the Draize rabbit eye irritation test by Verstraelen, Sandra, Jacobs, An, De Wever, Bart, Vanparys, Philippe

“…•Better spreading of compounds in the LLBO scaling compared to the OP-KIT scaling.•The LLBO underestimated less the peripheral induced opacity compared to the…”
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Development of a new opacitometer for the bovine corneal opacity and permeability (BCOP) assay by Verstraelen, S., Hansen, E., Van Goethem, F., Vanparys, P.

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ECVAM and Pharmaceuticals by Vanparys, Philippe

“…In the pharmaceutical industry, toxicology testing is normally done by preclinical scientists during the Development phase. In the last decade, the…”
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Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells by De Smedt, Ann, Steemans, Margino, De Boeck, Marlies, Peters, Annelieke K., van der Leede, Bas-jan, Van Goethem, Freddy, Lampo, Ann, Vanparys, Philippe

“…In order to support drug research in the selection process for non-embryotoxic pharmaceutical compounds, a screening method for embryotoxicity is needed. The…”
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Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity by Peters, Annelieke K., Wouwer, Gert Van de, Weyn, Barbara, Verheyen, Geert R., Vanparys, Philippe, Gompel, Jacques Van

“…The embryonic stem cell test (EST) is an ECVAM-validated assay to detect embryotoxicity. The output of the assay is the effect of test compounds on the…”
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The in vivo gut micronucleus test detects clastogens and aneugens given by gavage by Vanhauwaert, Annelies, Vanparys, Philippe, Kirsch-Volders, Micheline

“…A general testing battery for pharmaceuticals includes a bacterial gene mutation assay, an in vitro chromosomal aberration or a gene mutation test on mammalian…”
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Flow cytometric analysis of micronucleated reticulocytes: Time- and dose-dependent response of known mutagens in mice, using multiple blood sampling by De Boeck, Marlies, van der Leede, Bas-jan, Van Goethem, Freddy, De Smedt, Ann, Steemans, Margino, Lampo, Ann, Vanparys, Philippe

“…According to the current Organization of Economic Cooperation and Development (OECD) and International Committee on Harmonization (ICH) guidelines for the…”
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Safety aspects of oral antifungal agents by Van Cauteren, H, Lampo, A, Vandenberghe, J, Vanparys, P, Coussement, W, De Coster, R, Marsboom, R

“…Four main targets have to be considered when evaluating the safety of new systemically acting, oral antifungals: the liver, the endocrine system, serum…”
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Barriers to validation: a report by the European Partnership fo Alternative Approaches to Animal Testing (EPAA) Working Group 5 by Ahr, Hans-Jürgen, Alepée, Nathalie, Breier, Siegfried, Brekelmans, Cornelis, Cotgreave, Ian, Gribaldo, Laura, Dal Negro, Gianni, De Silva, Odile, Hartung, Thomas, Lacerda, Antonio, Leblanc, Bernard, Lecerf, Catherine, Linge, Jens P, Louhimies, Susanna, Manou, Irene, Maxwell, Gavin, Müller, Karsten K, Pape, Wolfgang, Redhead, Keith, Schröder, Klaus R, Sladowski, Dariusz, van der Jagt, Katinka, Vanparys, Phillipe

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Flow cytometric enumeration of micronucleated reticulocytes: High transferability among 14 laboratories by Torous, Dorothea K., Hall, Nikki E., Dertinger, Stephen D., Diehl, Marilyn S., Illi-Love, Anne H., Cederbrant, Karin, Sandelin, Kerstin, Bolcsfoldi, George, Ferguson, Lynnette R., Pearson, Amira, Majeska, Jenness B., Tarca, James P., Hewish, Dean R., Doughty, Larissa, Fenech, Michael, Weaver, James L., Broud, Dennis D., Gatehouse, David G., Hynes, Geoffrey M., Kwanyuen, Puntipa, McLean, Jack, McNamee, James P., Parenteau, Monique, Van Hoof, Veerle, Vanparys, Philippe, Lenarczyk, Marek, Siennicka, Joanna, Litwinska, Bogumila, Slowikowska, Maria G., Harbach, Philip R., Johnson, Carol W., Zhao, Shuou, Aaron, Charles S., Lynch, Anthony M., Marshall, Ian C., Rodgers, Brenda, Tometsko, Carol R.

“…This laboratory previously described a single‐laser flow cytometric method, which effectively resolves micronucleated erythrocyte populations in rodent…”
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The principles of good laboratory practice : Application to in vitro toxicology studies : The report and recommendations of ECVAM workshop 37 by COOPER-HANNAN, R, HARBELL, J. W, LIEBSCH, M, VANPARYS, P, COECKE, S, BALLS, M, BOWE, G, CERVINKA, M, CLOTHIER, R, HERMANN, F, KLAHM, L. K, DE LANGE, J

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Evaluation of the HET-CAM-TSA method as an alternative to the draize eye irritation test by Gilleron, L., Coecke, S., Sysmans, M., Hansen, E., van Oproy, S., Marzin, D., van Cauteren, H., Vanparys, Ph

“…The Hen's Egg Test-Chorioallantoic Membrane (HET-CAM) method was modified in our laboratory by means of microscopic evaluation, a clear description of the…”
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The mouse bone marrow micronucleus assay can be used to distinguish aneugens from clastogens by Vanderkerken, K, Vanparys, P, Verschaeve, L, Kirsch-Volders, M

“…The occurrence of aneuploidy can be measured in several assays. However, none of them have been sufficiently validated. The bone marrow micronucleus test may…”
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