Model-Base Estimation of Non-Invasive Ventilation Weaning of Preterm Infants Exposed to Osteopathic Manipulative Treatment: A Propensity-Score-Matched Cohort Study

Model-Base Estimation of Non-Invasive Ventilation Weaning of Preterm Infants Exposed to Osteopathic Manipulative Treatment: A Propensity-Score-Matched Cohort Study

Ventilation weaning is a key intensive care event influencing preterm infants’ discharge from a neonatal intensive care unit (NICU). Osteopathic manipulative treatment (OMT) has been recently introduced in some Italian NICUs. This retrospective cohort study tested if OMT is associated with faster no...

Full description

Saved in:
Bibliographic Details
Published in:Healthcare (Basel) Vol. 10; no. 12; p. 2379
Main Authors: Tarantino, Andrea Gianmaria, Vismara, Luca, Buffone, Francesca, Bianchi, Giuliana, Bergna, Andrea, Vanoni, Monica, Tabbi, Claudia, Bresesti, Ilia, Agosti, Massimo
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 27-11-2022
MDPI
Subjects:
Apgar score
Birth weight
Care and treatment
Cohort analysis
Drug dosages
Gestational age
Heart rate
Hospitals
Infants (Premature)
Intensive care
Manipulation (Therapeutics)
Mortality
Multidisciplinary teams
Neonatal intensive care
neonatal intensive care unit
Newborn babies
non-invasive ventilation weaning
osteopathic manipulative treatment
Osteopathic medicine
Oxygen saturation
Oxygen therapy
Patient outcomes
Pediatric research
Pediatrics
Premature babies
preterm infants
Respiration
Respiratory distress syndrome
Testing
Ventilator weaning
Ventilators
Weaning
Italy
non-invasive ventilation weaning
preterm infants
osteopathic manipulative treatment
neonatal intensive care unit
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ventilation weaning is a key intensive care event influencing preterm infants’ discharge from a neonatal intensive care unit (NICU). Osteopathic manipulative treatment (OMT) has been recently introduced in some Italian NICUs. This retrospective cohort study tested if OMT is associated with faster non-invasive ventilation (NIV) weaning. The time to NIV weaning was assessed in very preterm and very low birth weight infants who either received or did not receive OMT. The propensity score model included gender, antenatal steroids, gestational age (GA), birth weight (BW), and Apgar score 5′. Out of 93 infants, 40 were included in the multilevel survival analysis, showing a reduction of time to NIV weaning for GA (HR: 2.58, 95%CI: 3.91 to 1.71, p < 0.001) and OMT (HR: 3.62, 95%CI: 8.13 to 1.61, p = 0.002). Time to independent ventilation (TIV) was modeled with GA and BW as dependent variables and OMT as the factor. A negative linear effect of GA and BW on TIV was shown. OMT exposure studied as the factor of GA had effects on TIV in infants born up to the 32nd gestational week. Preterm infants exposed to OMT were associated with earlier achievement of NIV weaning. This result, together with the demonstrated OMT safety, suggests the conduct of clinical trials in preterm infants younger than 32 weeks of GA.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2227-9032
2227-9032
DOI:10.3390/healthcare10122379