Search Results - "Vanhoutte, Paul. M"

Macro‐ and microvascular endothelial dysfunction in diabetes by Shi, Yi, Vanhoutte, Paul M.

“…Highlights Diabetes affects endothelial function in both large blood vessels and the microvasculature. Diabetes‐induced endothelial dysfunction, especially in…”
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Vascular nitric oxide: Beyond eNOS by Zhao, Yingzi, Vanhoutte, Paul M., Leung, Susan W.S.

“…As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of cellular processes, including those involving vascular cells. This…”
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Endothelial Dysfunction: The First Step Toward Coronary Arteriosclerosis by Vanhoutte, Paul M.

“…The endothelium causes relaxations of the underlying vascular smooth muscle, by releasing nitric oxide (NO). The endothelial cells also can evoke…”
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Endothelium‐mediated control of vascular tone: COX‐1 and COX‐2 products by Félétou, Michel, Huang, Yu, Vanhoutte, Paul M

“…Endothelium‐dependent contractions contribute to endothelial dysfunction in various animal models of aging, diabetes and cardiovascular diseases. In the…”
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EDHF: an update by Félétou, Michel, Vanhoutte, Paul M

“…The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also by other pathways causing hyperpolarization of the underlying smooth…”
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Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture) by Félétou, Michel, Vanhoutte, Paul M

“…Endothelial cells synthesize and release various factors that regulate angiogenesis, inflammatory responses, hemostasis, as well as vascular tone and…”
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Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease by Xu, Aimin, Vanhoutte, Paul M

“…The heart and blood vessels are surrounded by epicardial and perivascular adipose tissues, respectively, which play important roles in maintaining…”
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Regenerated Endothelium and Its Senescent Response to Aggregating Platelets by Vanhoutte, Paul M.

“…This essay summarizes 30 years of work attempting to understand why regenerated endothelium becomes dysfunctional. It focuses on the activation of endothelial…”
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Adiponectin and cardiovascular health: an update by Hui, Xiaoyan, Lam, Karen SL, Vanhoutte, Paul M, Xu, Aimin

“…The global epidemic of obesity is accompanied by an increased prevalence of cardiovascular disease (CVD), in particular stroke and heart attack. Dysfunctional…”
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Nitric Oxide: From Good to Bad by Vanhoutte, Paul M.

“…This essay summarizes a lecture presented on October 19th, 2017, during the 58th Annual Meeting of the Japanese College of Angiology in Nagoya, Japan. The…”
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Nitric oxide: orchestrator of endothelium-dependent responses by Félétou, Michel, Köhler, Ralf, Vanhoutte, Paul M

“…The present review first summarizes the complex chain of events, in endothelial and vascular smooth muscle cells, that leads to endothelium-dependent…”
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Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood–brain barrier by Liao, Boya, Geng, Leiluo, Zhang, Fang, Shu, Lingling, Wei, Ling, Yeung, Patrick K K, Lam, Karen S L, Chung, Sookja K, Chang, Junlei, Vanhoutte, Paul M, Xu, Aimin, Wang, Kai, Hoo, Ruby L C

“…Abstract Aims Adipocyte fatty acid-binding protein (A-FABP) is an adipokine implicating in various metabolic diseases. Elevated circulating levels of A-FABP…”
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Oxidative Stress and Pathological Changes After Coronary Artery Interventions by Juni, Rio P., MD, MSc, Duckers, Henricus J., MD, PhD, Vanhoutte, Paul M., MD, PhD, Virmani, Renu, MD, PhD, Moens, An L., MD, PhD

“…Oxidative stress greatly influences the pathogenesis of various cardiovascular disorders. Coronary interventions, including balloon angioplasty and coronary…”
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Toll-Like Receptor 4 Mutation Protects Obese Mice Against Endothelial Dysfunction by Decreasing NADPH Oxidase Isoforms 1 and 4 by Liang, Chao-Fan, Liu, Jacky TC, Wang, Yu, Xu, Aimin, Vanhoutte, Paul M

“…OBJECTIVE—To analyze the role of toll-like receptor 4 in modulating metabolism and endothelial function. APPROACH AND RESULTS—Type 2 diabetic mice with mutated…”
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SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells by Zu, Yi, Liu, Ling, Lee, Mary Y.K, Xu, Cheng, Liang, Yan, Man, Ricky Y, Vanhoutte, Paul M, Wang, Yu

“…RATIONALE:Endothelial senescence causes endothelial dysfunction, promotes atherogenesis and contributes to age-related vascular disorders. SIRT1 is a conserved…”
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Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells by Guo, Yumeng, Xu, Cheng, Man, Andy W C, Bai, Bo, Luo, Cuiting, Huang, Yu, Xu, Aimin, Vanhoutte, Paul M, Wang, Yu

“…Abstract Aims Aged arteries are characterized by attenuated vasodilator and enhanced vasoconstrictor responses, which contribute to the development of diseases…”
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Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention by Zhu, Weidong, Cheng, Kenneth K Y, Vanhoutte, Paul M, Lam, Karen S L, Xu, Aimin

“…Adiponectin is a major adipocyte-secreted adipokine abundantly present in the circulation as three distinct oligomeric complexes. In addition to its role as an…”
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Endothelium‐dependent contractions in SHR: a tale of prostanoid TP and IP receptors by Félétou, Michel, Verbeuren, Tony J, Vanhoutte, Paul M

“…In the aorta of spontaneously hypertensive rats (SHR), the endothelial dysfunction is due to the release of endothelium‐derived contracting factors (EDCFs)…”
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Endothelial dysfunction: a strategic target in the treatment of hypertension? by Tang, Eva H. C., Vanhoutte, Paul M.

“…Endothelial dysfunction is a common feature of hypertension, and it results from the imbalanced release of endothelium-derived relaxing factors (EDRFs; in…”
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PDE and sGC hand in hand to see the light by Vanhoutte, Paul M.

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