Search Results - "Vanhoorne, Valérie"

Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours by Vidal, Arnau, Claeys, Liesel, Mengelers, Marcel, Vanhoorne, Valérie, Vervaet, Chris, Huybrechts, Bart, De Saeger, Sarah, De Boevre, Marthe

“…For the first time, a comprehensive human intervention study was conducted to unravel the urinary excretion profile and metabolism of the fungal metabolite…”
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Continuous Twin Screw Granulation: A Review of Recent Progress and Opportunities in Formulation and Equipment Design by Portier, Christoph, Vervaet, Chris, Vanhoorne, Valérie

“…Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical…”
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Continuous twin screw granulation: A complex interplay between formulation properties, process settings and screw design by Portier, Christoph, Pandelaere, Kenny, Delaet, Urbain, Vigh, Tamas, Di Pretoro, Giustino, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] Due to the numerous advantages over batch manufacturing, continuous manufacturing techniques such as twin screw wet granulation are rapidly…”
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Impact of alternative lubricants on process and tablet quality for direct compression by de Backere, Cedrine, Quodbach, Julian, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] Internal lubrication with magnesium stearate (MgSt) is associated with a reduced tensile strength and prolonged disintegration and…”
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A multivariate raw material property database to facilitate drug product development and enable in-silico design of pharmaceutical dry powder processes by Van Snick, Bernd, Dhondt, Jens, Pandelaere, Kenny, Bertels, Johny, Mertens, Roel, Klingeleers, Didier, Di Pretoro, Giustino, Remon, Jean Paul, Vervaet, Chris, De Beer, Thomas, Vanhoorne, Valérie

“…[Display omitted] In current study a holistic material characterization approach was proposed and an extensive raw material property database was developed…”
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Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press by de Backere, Cedrine, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] Internal lubrication can be associated with reduced tabletability. Deformation mechanism, lubricant type, lubricant blending time and paddle…”
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Screening of lubricants towards their applicability for external lubrication by de Backere, Cedrine, Surmont, Margot, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] Internal lubrication is associated with decreasing tensile strength and prolonged disintegration. These effects can be minimized using…”
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Upscaling of external lubrication from a compaction simulator to a rotary tablet press by de Backere, Cedrine, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered…”
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Effect of binder type and lubrication method on the binder efficacy for direct compression by de Backere, Cedrine, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] The effect of different binders for direct compression on tablet critical quality attributes was investigated. Dicalcium phosphate, lactose…”
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Advances in Twin-Screw Granulation by Vanhoorne, Valérie, Kumar, Ashish

“…Twin-screw granulation (TSG) is an emerging process technology that allows both wet and dry granulation of powders with a wide range of properties [...]…”
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Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a tablet press by De Leersnyder, Fien, Vanhoorne, Valérie, Kumar, Ashish, Vervaet, Chris, De Beer, Thomas

“…[Display omitted] •NIR as a PAT tool for in-line monitoring of blend potency in the feed frame of a rotary tablet press.•Residence time distribution…”
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Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters by Denduyver, Phaedra, Vervaet, Chris, Vanhoorne, Valérie

“…Hydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet…”
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Continuous twin screw granulation: Impact of binder addition method and surfactants on granulation of a high-dosed, poorly soluble API by Portier, Christoph, Vigh, Tamas, Di Pretoro, Giustino, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] Despite the recent commercialization of several drug products manufactured through continuous manufacturing techniques, knowledge on the…”
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Continuous twin screw granulation: Influence of process and formulation variables on granule quality attributes of model formulations by Portier, Christoph, Pandelaere, Kenny, Delaet, Urbain, Vigh, Tamas, Kumar, Ashish, Di Pretoro, Giustino, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] In recent years, continuous manufacturing techniques, such as twin screw wet granulation, have gained significant momentum. Due to the large…”
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Influence of formulation variables on the processability and properties of tablets manufactured by fused deposition modelling by Macedo, Joana, Vanhoorne, Valérie, Vervaet, Chris, Pinto, João F.

“…[Display omitted] •Mechanical properties (e.g. elasticity or brittleness) can be related to filaments printability.•Tablets presented uniformity of content and…”
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Evaluation of an external lubrication system implemented in a compaction simulator by de Backere, Cedrine, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] The internal blending of magnesium stearate is often associated with decreasing tensile strengths and longer disintegration and dissolution…”
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Continuous twin screw granulation: Robustness of lactose/MCC-based formulations by Portier, Christoph, De Vriendt, Charlotte, Vigh, Tamas, Di Pretoro, Giustino, De Beer, Thomas, Vervaet, Chris, Vanhoorne, Valérie

“…[Display omitted] In recent years, significant progress has been made in the field of continuous twin screw granulation. However, only limited knowledge is…”
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Solvent electrospinning amorphous solid dispersions with high itraconazole, celecoxib, mebendazole and fenofibrate drug loading and release potential by Becelaere, Jana, Frateur, Olmo, Schoolaert, Ella, Vanhoorne, Valérie, D'hooge, Dagmar R., Vervaet, Chris, Hoogenboom, Richard, De Clerck, Karen

“…In this work, the feasibility of ultra-high drug loaded amorphous solid dispersions (ASDs) for the poorly soluble itraconazole, mebendazole and celecoxib via…”
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Mixing and transport during pharmaceutical twin-screw wet granulation: Experimental analysis via chemical imaging by Kumar, Ashish, Vercruysse, Jurgen, Toiviainen, Maunu, Panouillot, Pierre-Emmanuel, Juuti, Mikko, Vanhoorne, Valérie, Vervaet, Chris, Remon, Jean Paul, Gernaey, Krist V., De Beer, Thomas, Nopens, Ingmar

“…[Display omitted] •Screw speed played dominating effect on residence time distribution.•Axial mixing was improved at low filling condition.•We proposed that…”
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Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl acetate 3D printed tablets using extrusion-based additive manufacturing? by Samaro, Aseel, Shaqour, Bahaa, Goudarzi, Niloofar Moazami, Ghijs, Michael, Cardon, Ludwig, Boone, Matthieu N., Verleije, Bart, Beyers, Koen, Vanhoorne, Valérie, Cos, Paul, Vervaet, Chris

“…[Display omitted] •The mechanical and rheological properties are limiting steps for FFF.•Increasing the VA content showed lower buckling stress, elastic and…”
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