Search Results - "Vanhaver, Christophe"

MDSC in Mice and Men: Mechanisms of Immunosuppression in Cancer by Vanhaver, Christophe, van der Bruggen, Pierre, Bruger, Annika M.

“…Myeloid-derived suppressor cells (MDSCs) expand during pathological conditions in both humans and mice and their presence is linked to poor clinical outcomes…”
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IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression by Hirsch, Thibault, Neyens, Damien, Duhamel, Céline, Bayard, Alexandre, Vanhaver, Christophe, Luyckx, Mathieu, Sala de Oyanguren, Francisco, Wildmann, Claude, Dauguet, Nicolas, Squifflet, Jean-Luc, Montiel, Virginie, Deschamps, Mélanie, van der Bruggen, Pierre

“…Human CD8 tumor-infiltrating lymphocytes (TILs) with impaired effector functions and PD-1 expression are categorized as exhausted. However, the exhaustion-like…”
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HELIOS-expressing human CD8 T cells exhibit limited effector functions by Neyens, Damien, Hirsch, Thibault, Abdel Aziz Issa Abdel Hadi, Achraqat, Dauguet, Nicolas, Vanhaver, Christophe, Bayard, Alexandre, Wildmann, Claude, Luyckx, Mathieu, Squifflet, Jean-Luc, D'Hondt, Quentin, Duhamel, Céline, Huaux, Antoine, Montiel, Virginie, Dechamps, Mélanie, van der Bruggen, Pierre

“…The transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted…”
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Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis by Lecomte, Sara, Devreux, Julien, de Streel, Grégoire, van Baren, Nicolas, Havelange, Violaine, Schröder, David, Vaherto, Noora, Vanhaver, Christophe, Vanderaa, Christophe, Dupuis, Noémie, Pecquet, Christian, Coulie, Pierre G., Constantinescu, Stefan N., Lucas, Sophie

“…•Anti-GARP:TGF-β1 mAb exerts antitumor activity in myeloproliferative neoplasms by selectively blocking Treg-derived TGF-β1.•Targeting Treg functions is…”
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Immunosuppressive low-density neutrophils in the blood of cancer patients display a mature phenotype by Vanhaver, Christophe, Aboubakar Nana, Frank, Delhez, Nicolas, Luyckx, Mathieu, Hirsch, Thibault, Bayard, Alexandre, Houbion, Camille, Dauguet, Nicolas, Brochier, Alice, van der Bruggen, Pierre, Bruger, Annika M

“…The presence of human neutrophils in the tumor microenvironment is strongly correlated to poor overall survival. Most previous studies have focused on the…”
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Protocol to assess the suppression of T-cell proliferation by human MDSC by Bruger, Annika M, Vanhaver, Christophe, Bruderek, Kirsten, Amodio, Giada, Tavukçuoğlu, Ece, Esendagli, Günes, Gregori, Silvia, Brandau, Sven, van der Bruggen, Pierre

“…Inhibition of T-cell proliferation is the most common approach to assess human myeloid-derived suppressor cell (MDSC) functions. However, diverse methodologies…”
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Reverse immunology: From peptide sequence to tumor-killing human T-cell clones by Vanhaver, Christophe, Gordon-Alonso, Monica, Bayard, Alexandre, Catanese, Maria Teresa, Colau, Didier, van der Bruggen, Pierre, Bruger, Annika M

“…Recent advances in next generation sequencing expanded the availability of tumor mutanome data that list the mutations present in cancer cells. Mutated…”
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