Search Results - "Vanhanen, Reetta"

Characterization of human T cell receptor repertoire data in eight thymus samples and four related blood samples by Heikkilä, Nelli, Kleino, Iivari, Vanhanen, Reetta, Yohannes, Dawit A., Mattila, Ilkka P., Saramäki, Jari, Arstila, T. Petteri

“…T cell receptor (TCR) is a heterodimer consisting of TCRα and TCRβ chains that are generated by somatic recombination of multiple gene segments. Nascent TCR…”
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Epigenetic and transcriptional analysis supports human regulatory T cell commitment at the CD4+CD8+ thymocyte stage by Vanhanen, Reetta, Leskinen, Katarzyna, Mattila, Ilkka P., Saavalainen, Päivi, Arstila, T. Petteri

“…•Regulatory T cell commitment begins at the CD4+CD8+ double positive stage.•Epigenetic analysis shows stable expression of FOXP3 in DP CD25+ thymocytes.•DP…”
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Human thymic T cell repertoire is imprinted with strong convergence to shared sequences by Heikkilä, Nelli, Vanhanen, Reetta, Yohannes, Dawit A., Kleino, Iivari, Mattila, Ilkka P., Saramäki, Jari, Arstila, T. Petteri

“…•In thymus the TCRα repertoire is more diverse than the TCRβ repertoire and contains more nonproductive clonotypes.•A high proportion of thymic TCRs is shared…”
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Common gamma chain cytokines promote regulatory T cell development and survival at the CD4+ CD8+ stage in the human thymus by Vanhanen, Reetta, Tuulasvaara, Anni, Mattila, Joonatan, Pätilä, Tommi, Arstila, T. Petteri

“…Thymic commitment of human FOXP3+ regulatory T cells begins at the double‐positive (DP) CD4+ CD8+ stage. In the current study, we show that interleukin‐2…”
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Common gamma chain cytokines promote regulatory T cell development and survival at the CD 4 +   CD 8 + stage in the human thymus by Vanhanen, Reetta, Tuulasvaara, Anni, Mattila, Joonatan, Pätilä, Tommi, Arstila, T. Petteri

“…Abstract Thymic commitment of human FOXP 3 + regulatory T cells begins at the double‐positive ( DP ) CD 4 +   CD 8 + stage. In the current study, we show that…”
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Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins by Heikkilä, Nelli, Vanhanen, Reetta, Yohannes, Dawit A., Saavalainen, Päivi, Meri, Seppo, Jokiranta, T. Sakari, Jarva, Hanna, Mattila, Ilkka P., Hamm, David, Sormunen, Silja, Saramäki, Jari, Arstila, T. Petteri

“…We have analyzed T cell receptor repertoires in a unique set of thymus samples from a pair of monozygotic twins. While genetics affect the V(D)J rearrangement…”
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T cell receptor diversity in the human thymus by Vanhanen, Reetta, Heikkilä, Nelli, Aggarwal, Kunal, Hamm, David, Tarkkila, Heikki, Pätilä, Tommi, Jokiranta, T. Sakari, Saramäki, Jari, Arstila, T. Petteri

“…•The data provides the first measurement of the human thymic T cell receptor diversity.•High-throughput sequencing of the human thymus produced 10×106 unique…”
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Interleukin‐7 promotes human regulatory T cell development at the CD4+CD8+ double‐positive thymocyte stage by Tuulasvaara, Anni, Vanhanen, Reetta, Baldauf, Hanna‐Mari, Puntila, Juha, Arstila, T. Petteri

“…IL‐7 promotes regulatory T cell development in the human thymus by inhibiting apoptosis and enhancing emergence of the regulatory phenotype. Although mature…”
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Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells by Hetemäki, Iivo, Kaustio, Meri, Kinnunen, Matias, Heikkilä, Nelli, Keskitalo, Salla, Nowlan, Kirsten, Miettinen, Simo, Sarkkinen, Joona, Glumoff, Virpi, Andersson, Noora, Kettunen, Kaisa, Vanhanen, Reetta, Nurmi, Katariina, Eklund, Kari K, Dunkel, Johannes, Mäyränpää, Mikko I, Schlums, Heinrich, Arstila, T Petteri, Kisand, Kai, Bryceson, Yenan T, Peterson, Pärt, Otava, Ulla, Syrjänen, Jaana, Saarela, Janna, Varjosalo, Markku, Kekäläinen, Eliisa

“…The Ikaros family transcription factors regulate lymphocyte development. Loss-of-function variants in cause primary immunodeficiency, but Ikaros family members…”
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