Search Results - "Vangipurapu, J."

novel surrogate index for hepatic insulin resistance by Vangipurapu, J, Stančáková, A, Kuulasmaa, T, Paananen, J, Kuusisto, J, Ferrannini, E, Laakso, M

“…Aims/hypothesis In epidemiological and genetic studies surrogate indices are needed to investigate insulin resistance in different insulin-sensitive tissues…”
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Association between liver insulin resistance and cardiovascular risk factors by Vangipurapu, J., Stančáková, A., Kuulasmaa, T., Soininen, P., Kangas, A. J., Ala-Korpela, M., Kuusisto, J., Laakso, M.

“…  Vangipurapu J, Stančáková A, Kuulasmaa T, Soininen P, Kangas AJ, Ala‐Korpela M, Kuusisto J, Laakso M (University of Eastern Finland and Kuopio University…”
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Genetic architecture of oral glucose-stimulated insulin release provides biological insights into type 2 diabetes aetiology by Madsen, A. L., Bonàs-Guarch, S., Gheibi, S., Prasad, R., Vangipurapu, J., Ahuja, V., Cataldo, L. R., Dwivedi, O., Hatem, G., Atla, G., Guindo-Martínez, M., Jørgensen, A. M., Jonsson, A. E., Miguel-Escalada, I., Hassan, S., Linneberg, A., Ahluwalia, Tarunveer S., Drivsholm, T., Pedersen, O., Sørensen, T. I. A., Astrup, A., Witte, D., Damm, P., Clausen, T. D., Mathiesen, E., Pers, T. H., Loos, R. J. F., Hakaste, L., Fex, M., Grarup, N., Tuomi, T., Laakso, M., Mulder, H., Ferrer, J., Hansen, T.

“…The genetics of β-cell function (BCF) offer valuable insights into the aetiology of type 2 diabetes (T2D) 1 , 2 . Previous studies have expanded the catalogue…”
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Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men by Vangipurapu, J, Stančáková, A, Pihlajamäki, J, Kuulasmaa, T. M, Kuulasmaa, T, Paananen, J, Kuusisto, J, Ferrannini, E, Laakso, M

“…Aims/hypothesis Of the confirmed type 2 diabetes susceptibility loci only a few are known to affect insulin sensitivity. We examined the association of indices…”
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Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men by Vangipurapu, Jagadish, Stancáková, Alena, Smith, Ulf, Kuusisto, Johanna, Laakso, Markku

“…Several amino acids (AAs) have been shown to be associated with insulin resistance and increased risk of type 2 diabetes, but no previous studies have…”
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Prevalence, genotype and phenotype of familial hypercholesterolemia in 10,194 Finnish men by Korhonen, L, Maria, M, Vangipurapu, J, Laakso, M, Kuusisto, J

“…Abstract Background Familial hypercholesterolemia (FH) is the most frequent monogenic disease with an estimated prevalence of 1:250. The prevalence of…”
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Microbiota-Related Metabolites and the Risk of Type 2 Diabetes by Vangipurapu, Jagadish, Fernandes Silva, Lilian, Kuulasmaa, Teemu, Smith, Ulf, Laakso, Markku

“…Recent studies have highlighted the significance of the microbiome in human health and disease. Changes in the metabolites produced by microbiota have been…”
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A reference map of potential determinants for the human serum metabolome by Bar, Noam, Korem, Tal, Weissbrod, Omer, Zeevi, David, Rothschild, Daphna, Leviatan, Sigal, Kosower, Noa, Lotan-Pompan, Maya, Weinberger, Adina, Le Roy, Caroline I., Menni, Cristina, Visconti, Alessia, Falchi, Mario, Spector, Tim D., Adamski, Jerzy, Franks, Paul W., Pedersen, Oluf, Segal, Eran

“…The serum metabolome contains a plethora of biomarkers and causative agents of various diseases, some of which are endogenously produced and some that have…”
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Polygenic risk scores in predicting the presence of coronary artery disease in symptomatic patients - A validation study utilizing an accurate phenotype based on state-of-the-art imaging by Kujala, I, Vangipurapu, J, Maaniitty, T, Saraste, A, Kere, J, Knuuti, J

“…Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Academy of Finland Turku University Hospital…”
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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention by Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J., Cornelis, Marilyn C., Mazzaferro, Eugenia, Broos, Siacia, Bentley, Amy R., Chong, Mike, Berry, Diane, Feenstra, Bjarke, Feitosa, Mary F., Hall, Leanne M., Huikari, Ville, Karlsson, Robert, Kerr, Kathleen F., Kim, Boram, Monroe, Kristine R., Richmond, Rebecca C., Rivera, Natalia V., Turman, Constance, van Rooij, Frank J. A., Zhao, Jing-Hua, Zhao, Wei, Baumeister, Sebastian E., Brage, Soren, Cole, John W., Collins, Francis S., Cupples, L. Adrienne, Franco, Oscar H., Galesloot, Tessel E., Grarup, Niels, Hui, Jennie, Illig, Thomas, Jago, Russell, James, Alan, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter P., Li, Aihua, Vidal, Pedro Marques, Medland, Sarah E., Milaneschi, Yuri, Pedersen, Nancy L., Peyser, Patricia A., Power, Christine, Raitakari, Olli T., Ridker, Paul M., Rudan, Igor, Sarzynski, Mark A., Scott, Laura J., Scott, Robert A., Siggeirsdottir, Kristin, Teo, Koon K., Thorand, Barbara, Xu, Huichun, Young, Kristin L., Zillikens, M. Carola, Zonderman, Alan B., Ameur, Adam, Bandinelli, Stefania, Bouchard, Claude, Chasman, Daniel I., Deldicque, Louise, Fornage, Myriam, Gudnason, Vilmundur, Gyllensten, Ulf, Hayward, Caroline, Horta, Bernardo L., Hyppönen, Elina, Kardia, Sharon L. R., Kiemeney, Lambertus A., Langenberg, Claudia, Lehtimäki, Terho, Marchand, Loic Le, Magnusson, Patrik K. E., Martin, Nicholas G., Melbye, Mads, Metspalu, Andres, Meyre, David, North, Kari E., Ohlsson, Claes, Pare, Guillaume, Park, Taesung, Pedersen, Oluf, Pers, Tune H., Samani, Nilesh J., Sim, Xueling, Snieder, Harold, Spector, Tim D., van Dam, Rob M., van der Velde, Nathalie, Vollenweider, Peter, Voortman, Trudy, Waeber, Gérard, Wareham, Nicholas J., Wichmann, Heinz-Erich, Krook, Anna, Zierath, Juleen R., Thomis, Martine A. I.

“…Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data…”
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P4663Hyperinsulinemia, hypertension and two clusters of biomarkers predict aortic stenosis in 10,144 Finnish men by Ojanen, M, Jauhiainen, R, Vangipurapu, J, Kuulasmaa, T, Kuusisto, J, Laakso, M

“…Abstract BACKROUND Recent studies show that hypertension predicts aortic stenosis (AS). Other predictors of AS are not established. Purpose To investigate a…”
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Metabolite Signature of Albuminuria Involves Amino Acid Pathways in 8661 Finnish Men Without Diabetes by Fernandes Silva, Lilian, Vangipurapu, Jagadish, Smith, Ulf, Laakso, Markku

“…Abstract Objective To investigate the metabolite signature of albuminuria in individuals without diabetes or chronic kidney disease to identify possible…”
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Polygenic Risk Scores in Predicting Coronary Artery Disease in Symptomatic Patients. A Validation Study by Kujala, Iida, Vangipurapu, Jagadish, Maaniitty, Teemu, Saraste, Antti, Kere, Juha, Knuuti, Juhani

“…Aim: Clinical risk scores for coronary artery disease (CAD) are used in clinical practice to select patients for diagnostic testing and therapy. Several…”
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Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion by Yaghootkar, Hanieh, Stancáková, Alena, Freathy, Rachel M, Vangipurapu, Jagadish, Weedon, Michael N, Xie, Weijia, Wood, Andrew R, Ferrannini, Ele, Mari, Andrea, Ring, Susan M, Lawlor, Debbie A, Davey Smith, George, Jørgensen, Torben, Hansen, Torben, Pedersen, Oluf, Steinthorsdottir, Valgerdur, Guðbjartsson, Daniel F, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Stefansson, Kari, Hattersley, Andrew T, Walker, Mark, Morris, Andrew D, McCarthy, Mark I, Palmer, Colin N A, Laakso, Markku, Frayling, Timothy M

“…A recent study identified a low-frequency variant at CCND2 associated with lower risk of type 2 diabetes, enhanced insulin response to a glucose challenge,…”
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Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in Finnish men by Cederberg, Henna, Gylling, Helena, Miettinen, Tatu A, Paananen, Jussi, Vangipurapu, Jagadish, Pihlajamäki, Jussi, Kuulasmaa, Teemu, Stančáková, Alena, Smith, Ulf, Kuusisto, Johanna, Laakso, Markku

“…We investigated the levels of non-cholesterol sterols as predictors for the development of hyperglycemia (an increase in the glucose area under the curve in an…”
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