Search Results - "Vangapandu, Surya N."

Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma by Aneja, Ritu, Vangapandu, Surya N, Lopus, Manu, Chandra, Ramesh, Panda, Dulal, Joshi, Harish C

“…We have shown previously that an antitussive plant alkaloid, noscapine, binds tubulin, displays anticancer activity, and has a safe pharmacological profile in…”
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Multidrug Resistance-Associated Protein-Overexpressing Teniposide-Resistant Human Lymphomas Undergo Apoptosis by a Tubulin-Binding Agent by ANEJA, Ritu, MIN LIU, YATES, Clayton, JINMIN GAO, XIN DONG, BINFEI ZHOU, VANGAPANDU, Surya N, JUN ZHOU, JOSHI, Harish C

“…Several DNA- and microtubule-binding agents are used to manage hematologic malignancies in the clinic. However, drug resistance has been a challenge, perhaps…”
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Rational design of the microtubule-targeting anti-breast cancer drug EM015 by ANEJA, Ritu, LOPUS, Manu, CHANDRA, Ramesh, JOSHI, Harish C, JUN ZHOU, VANGAPANDU, Surya N, GHALEB, Amr, YAO, Joyce, NETTLES, James H, BINFEI ZHOU, GUPTA, Meenakshi, PANDA, Dulal

“…We studied in silico docking of noscapine onto tubulin, combined with calculations of surface charge, pi-pi, van der Waals, and hydrogen bonding interactions,…”
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Rational design, synthesis and biological evaluations of amino-noscapine: a high affinity tubulin-binding noscapinoid by Naik, Pradeep K., Chatterji, Biswa Prasun, Vangapandu, Surya N., Aneja, Ritu, Chandra, Ramesh, Kanteveri, Srinivas, Joshi, Harish C.

“…Noscapine and its derivatives are important microtubule-interfering agents shown to have potent anti-tumor activity. The binding free energies (Δ G bind ) of…”
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In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin) by Naik, Pradeep K., Lopus, Manu, Aneja, Ritu, Vangapandu, Surya N., Joshi, Harish C.

“…Our screen for tubulin-binding small molecules that do not depolymerize bulk cellular microtubules, but based upon structural features of well known…”
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Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death by Aneja, Ritu, Vangapandu, Surya N., Lopus, Manu, Viswesarappa, Vijaya G., Dhiman, Neerupma, Verma, Akhilesh, Chandra, Ramesh, Panda, Dulal, Joshi, Harish C.

“…We have previously identified the naturally occurring non-toxic antitussive phthalideisoquinoline alkaloid, noscapine as a tubulin-binding agent that arrests…”
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Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analog by Aneja, Ritu, Vangapandu, Surya N., Joshi, Harish C.

“…We present here a novel semi-synthetic cyclic ether fluorinated noscapine analog (CEFNA) that shows potent antiproliferative and anticancer activity in both…”
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Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicrotubule agent, EM011 by Aneja, Ritu, Zhou, Jun, Vangapandu, Surya N., Zhou, Binfei, Chandra, Ramesh, Joshi, Harish C.

“…We have shown previously that EM011, a synthetic compound, binds tubulin with a higher affinity than the founding compound, noscapine, without changing total…”
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Recent patents on proteases and kinases as anti-infective agents: a review by Vangapandu, Surya N, Aneja, Ritu, Chandra, Ramesh, Joshi, Harish C

“…Infectious diseases have haunted human populations for millennia. Still we are struggling with this scourge because of multiple complexities. These include the…”
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Corrigendum to “Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death” [Biochem. Pharmacol. 72 (4) (2006) 415–426] by Aneja, Ritu, Vangapandu, Surya N., Lopus, Manu, Viswesarappa, Vijaya G., Dhiman, Neerupma, Verma, Akhilesh, Chandra, Ramesh, Panda, Dulal, Joshi, Harish C.

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Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicrotubule agent, EM011. Commentary by HEIDEMANN, Steven, ANEJA, Ritu, JUN ZHOU, VANGAPANDU, Surya N, BINFEI ZHOU, CHANDRA, Ramesh, JOSHI, Harish C

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