Search Results - "Vanessa Costhek Abílio"
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Antipsychotic profile of cannabidiol and rimonabant in an animal model of emotional context processing in schizophrenia
Published in Current pharmaceutical design (01-11-2012)“…Clinical and neurobiological findings suggest that cannabinoids and their receptors are implicated in schizophrenia. Cannabidiol (CBD), a non-psychotomimetic…”
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Neuroleptic Drugs Revert the Contextual Fear Conditioning Deficit Presented by Spontaneously Hypertensive Rats: A Potential Animal Model of Emotional Context Processing in Schizophrenia?
Published in Schizophrenia bulletin (01-07-2009)“…Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that…”
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Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?
Published in Frontiers in pharmacology (04-02-2021)“…Schizophrenia and autism spectrum disorders (ASD) are psychiatric neurodevelopmental disorders that cause high levels of functional disabilities. Also, the…”
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Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats
Published in Behavioural brain research (20-11-2011)“…• SHR present positive and negative symptoms-like behaviors related to schizophrenia. • Positive-like symptom is attenuated by typical and atypical…”
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SPEM: a state-of-the-art instrument for high resolution molecular imaging of small animal organs
Published in Einstein (São Paulo, Brazil) (01-06-2012)“…To describe the Single Photon Emission Microscope (SPEM), a state-of-the-art instrument for small animal SPECT imaging, and characterize its performance…”
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Cannabidiol and Sodium Nitroprusside: Two Novel Neuromodulatory Pharmacological Interventions to Treat and Prevent Psychosis
Published in CNS & neurological disorders drug targets (01-01-2015)“…Since most patients with schizophrenia do not respond properly to treatment, scientific effort has been driven to the development of new compounds acting on…”
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The contextual fear conditioning deficit presented by spontaneously hypertensive rats (SHR) is not improved by mood stabilizers
Published in Progress in neuro-psychopharmacology & biological psychiatry (15-08-2011)“…We have recently reported that spontaneously hypertensive rats (SHR) present a contextual fear conditioning (CFC) deficit. This deficit is improved by…”
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Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine
Published in Progress in neuro-psychopharmacology & biological psychiatry (15-08-2011)“…Deficits in an operational measure of sensorimotor gating – the prepulse inhibition of startle (PPI) – are presented in psychiatric disorders such as…”
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Contextual exploration previous to an aversive event predicts long-term emotional consequences of severe stress
Published in Frontiers in behavioral neuroscience (2013)“…Traumatic stress can lead to long-term emotional alterations, which may result in Posttraumatic Stress Disorder (PTSD). Fear reactions triggered by conditioned…”
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Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine
Published in Progress in neuro-psychopharmacology & biological psychiatry (01-07-2008)“…We have recently demonstrated that paradoxical sleep deprivation (PSD) potentiates the induction of amphetamine (AMPH)-induced behavioural sensitization by…”
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Effects of environmental enrichment and paradoxical sleep deprivation on open-field behavior of amphetamine-treated mice
Published in Physiology & behavior (23-11-2007)“…Abstract Background Environmental enrichment or paradoxical sleep deprivation (PSD) has been shown to modify some responses elicited by drugs of abuse. The…”
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Role of the endocannabinoid and endovanilloid systems in an animal model of schizophrenia-related emotional processing/cognitive deficit
Published in Neuropharmacology (01-09-2019)“…Studies suggest that the endocannabinoid and endovanilloid systems are implicated in the pathophysiology of schizophrenia. The Spontaneously Hypertensive Rats…”
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A schizophrenia-like behavioral trait in the SHR model: Applying confirmatory factor analysis as a new statistical tool
Published in Progress in neuro-psychopharmacology & biological psychiatry (13-07-2018)“…Questionnaires that assess symptoms of schizophrenia patients undergo strict statistical validation, often using confirmatory factor analysis (CFA). CFA allows…”
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Peripubertal exposure to environmental enrichment prevents schizophrenia-like behaviors in the SHR strain animal model
Published in Schizophrenia research (01-10-2016)“…Abstract Schizophrenia is a highly disabling mental disorder, in which genetics and environmental factors interact culminating in the disease. The treatment of…”
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Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naïve patients with first-episode psychosis
Published in European neuropsychopharmacology (01-12-2015)“…Abstract Schizophrenia is a multifactorial neurodevelopmental disorder with high heritability. First-episode psychosis (FEP) is a critical period for…”
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Effect of antipsychotic drugs on gene expression in the prefrontal cortex and nucleus accumbens in the spontaneously hypertensive rat (SHR)
Published in Schizophrenia research (01-08-2014)“…Abstract Antipsychotic drugs (APDs) are the standard treatment for schizophrenia. The therapeutic effect of these drugs is dependent upon the dopaminergic D2…”
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Expression profile of neurotransmitter receptor and regulatory genes in the prefrontal cortex of spontaneously hypertensive rats: Relevance to neuropsychiatric disorders
Published in Psychiatry research (30-11-2014)“…Abstract The spontaneously hypertensive rat (SHR) strain was shown to be a useful animal model to study several behavioral, pathophysiological and…”
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Evaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: A follow-up study in antipsychotic-naïve patients with first-episode psychosis
Published in Journal of psychiatric research (01-09-2014)“…Abstract A study of the gene expression levels in the blood of individuals with schizophrenia in the beginning of the disease, such as first-episode psychosis…”
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Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain
Published in Frontiers in pharmacology (2014)“…Clinical and neurobiological findings suggest that the cannabinoids and the endocannabinoid system may be implicated in the pathophysiology and treatment of…”
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