Search Results - "Vane, J.R."

Endothelin-1 release from endothelial cells in culture is elevated both acutely and chronically by short periods of mechanical stretch by Macarthur, H, Warner, T D, Wood, E G, Corder, R, Vane, J R

“…The effects were examined of mechanical stretch on the release of endothelin-1 (ET-1) and prostacyclin (measured as 6-keto-prostaglandin (PG) F1 alpha) from…”
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The mechanism of action of aspirin by Vane, J.R, Botting, R.M

“…The therapy of rheumatism began thousands of years ago with the use of decoctions or extracts of herbs or plants such as willow bark or leaves, most of which…”
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Support of renal blood flow after ischaemic‐reperfusion injury by endogenous formation of nitric oxide and of cyclo‐oxygenase vasodilator metabolites by Cristol, J.P., Thiemermann, C., Mitchell, J.A., Walder, C., Vane, J.R.

“…1 Ischaemia‐reperfusion injury in the kidney is associated with a loss of autoregulation, an increase in renal vascular resistance (RVR), a decrease of renal…”
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Dihydropyridine antagonists and agonists of calcium channels inhibit the induction of nitric oxide synthase by endotoxin in cultured macrophages by Szabó, C, Thiemermann, C, Vane, J R

“…Here we investigate the effects of the dihydropyridine-type antagonists of calcium channels nitrendipine, nimodipine, nisoldipine and the calcium channel…”
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Modification of energy metabolism and radiation response of a murine tumour by changes in nitric oxide availability by Wood, P J, Stratford, I J, Adams, G E, Szabo, C, Thiemermann, C, Vane, J R

“…The nitric oxide donor, SIN-1 and nitric oxide synthase inhibitor, nitro-L-arginine were examined for their effects on energy metabolism using 31P magnetic…”
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Recirculation of prostacyclin (PGI2) in the dog by Dusting, G.J, Moncada, S, Vane, J.R

“…1 The inactivation of prostacyclin (PGI2) in the circulation of anaesthetized dogs has been studied by the blood‐bathed organ bioassay technique. 2 Spiral…”
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Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium by Moncada, S, Herman, A G, Higgs, E A, Vane, J R

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Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets by Tateson, J E, Moncada, S, Vane, J R

“…Prostacyclin (PGX) strikingly increases cyclic AMP concentrations in human platelets. Prostacyclin is approximately 10 times more active than PGD2, 30 times…”
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Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species by Whittle, B J, Moncada, S, Vane, J R

“…The activity of prostacyclin (PGI2), PGE1 or PGD2 as inhibitors of platelet aggregation in plasma from human, dog, rabbit, rat, sheep and horse was…”
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THE DISTRIBUTION AND METABOLISM OF ARACHIDONIC ACID IN RABBIT PLATELETS DURING AGGREGATION AND ITS MODIFICATION BY DRUGS by BLACKWELL, G.J., DUNCOMBE, W.G., FLOWER, R.J., PARSONS, M.F., VANE, J.R.

“…1Gas chromatographic and radio‐isotope labelling techniques have been used to establish the origin of the arachidonic acid used by the platelet cyclo‐oxygenase…”
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Effects of all cis-5,8,11,14,17 eicosapentaenoic acid and PGH3 on platelet aggregation by Gryglewski, R J, Salmon, J A, Ubatuba, F B, Weatherly, B C, Moncada, S, Vane, J R

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The use of stable prostaglandins to investigate prostacyclin (PGI2)-binding sites and PGI2-sensitive adenylate cyclase in human platelet membranes by Lombroso, M, Nicosia, S, Paoletti, R, Whittle, B J, Moncada, S, Vane, J R

“…Prostacyclin, (PGI2) is a potent but unstable inhibitor of platelet aggregation, probably acting through stimulation of adenylate cyclase. A stable analogue of…”
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PROSTAGLANDIN PRODUCTION BY RABBIT ISOLATED JEJUNUM AND ITS RELATIONSHIP TO THE INHERENT TONE OF THE PREPARATION by FERREIRA, S.H., HERMAN, A.G., VANE, J.R.

“…1 Pieces of rabbit jejunum were bathed in Krebs solution at 37°C in an isolated organ bath bubbled with O2 and 5% CO2. The bathing fluid was collected…”
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Involvement of tyrosine kinase in the induction of cyclo‐oxygenase and nitric oxide synthase by endotoxin in cultured cells by Akarasereenont, P., Mitchell, J.A., Appleton, I., Thiemermann, C., Vane, J.R.

“…1 Cyclo‐oxygenase (COX) and nitric oxide synthase (NOS) are two enzymes which have distinct cytokine‐inducible isoforms (COX‐2 and iNOS). Many cytokine…”
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PHOSPHOLIPASE A2 ACTIVITY OF GUINEA‐PIG ISOLATED PERFUSED LUNGS: STIMULATION, AND INHIBITION BY ANTI‐INFLAMMATORY STEROIDS by BLACKWELL, G.J., FLOWER, R.J., NIJKAMP, F.P., VANE, J.R.

“…1 A simple double‐isotope assay for phospholipase A2 activity of perfused organs is described. 2 Guinea‐pig lungs perfused through the pulmonary circulation…”
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Cytokine‐mediated induction of cyclo‐oxygenase‐2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide by Akarasereenont, P., Bakhle, Y.S., Thiemermann, C., Vane, J.R.

“…1 The induction of cyclo‐oxygenase‐2 (COX‐2) afforded by bacterial lipopolysaccharide (LPS, endotoxin) in bovine aortic endothelial cells (BAEC) is mediated by…”
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Receptor-Mediated Release of Endothelium-Derived Relaxing Factor and Prostacyclin from Bovine Aortic Endothelial Cells is Coupled by De Nucci, Gilberto, Gryglewski, Richard J., Warner, Timothy D., Vane, John R.

“…Bovine aortic endothelial cells were grown on microcarrier beads and were perfused with Krebs-Ringer solution. Endothelium-derived relaxing factor (EDRF) was…”
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The Metabolism of L-Arginine and Its Significance for the Biosynthesis of Endothelium-Derived Relaxing Factor: L-Glutamine Inhibits the Generation of L-Arginine by Cultured Endothelial Cells by Sessa, William C., Hecker, Markus, Mitchell, Jane A., Vane, John R.

“…The mechanism by which L-glutamine (L-Gln) inhibits the release of endothelium-derived relaxing factor from bovine aortic cultured endothelial cells was…”
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A sensitive method for the assay of 5‐hydroxytryptamine by Vane, J.R., Vane, J.R.

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The use of isolated organs for detecting active substances in the circulating blood by Vane, J.R.

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