Search Results - "Vane, J. R."

The mechanism of action of aspirin by Vane, J.R, Botting, R.M

“…The therapy of rheumatism began thousands of years ago with the use of decoctions or extracts of herbs or plants such as willow bark or leaves, most of which…”
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Cyclooxygenases 1 and 2 by Vane, J R, Bakhle, Y S, Botting, R M

“…Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991,…”
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Selectivity of Nonsteroidal Antiinflammatory Drugs as Inhibitors of Constitutive and Inducible Cyclooxygenase by Mitchell, Jane A., Akarasereenont, Pravit, Thiemermann, Christoph, Flower, Roderick J., Vane, John R.

“…Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1) is present in cells under physiological conditions, whereas COX-2 is…”
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Inducible Isoforms of Cyclooxygenase and Nitric-Oxide Synthase in Inflammation by Vane, John R., Mitchell, Jane A., Appleton, Ian, Tomlinson, Annette, Bishop-Bailey, David, Croxtall, Jamie, Willoughby, Derek A.

“…Cyclooxygenase (COX) converts arachidonic acid to prostaglandin H2, which is further metabolized to prostanoids. Two isoforms of COX exist: a constitutive…”
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Mechanism of action of anti-inflammatory drugs by Vane, J R, Botting, R M

“…Cyclooxygenase (COX) is the pivotal enzyme in prostaglandin biosynthesis. It exists in two isoforms, constitutive COX-1 (responsible for physiological…”
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Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid by Desai, K. M, Sessa, W. C, Vane, J. R

“…The fundus of the guinea-pig stomach actively dilates in response to low increases in intragastric pressure. This physiological response, now called adaptive…”
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The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase by Thiemermann, Christoph, Ruetten, Hartmut, Wu, Chin‐Chen, Vane, John R.

“…1 We have investigated whether (i) endotoxaemia caused by E. coli lipopolysaccharide in the anaesthetized rat causes a multiple organ dysfunction syndrome…”
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Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock by Szabó, Csaba, Mitchell, Jane A., Thiemermann, Christoph, Vane, John R.

“…1 The role of an enhanced formation of nitric oxide (NO) and the relative importance of the constitutive and inducible NO synthase (NOS) for the development of…”
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Pressor Effects of Circulating Endothelin are Limited by its Removal in the Pulmonary Circulation and by the Release of Prostacyclin and Endothelium-Derived Relaxing Factor by De Nucci, Gilberto, Thomas, Roger, D'Orleans-Juste, Pedro, Antunes, Edson, Walder, Claire, Warner, Timothy D., Vane, John R.

“…Endothelin releases prostacyclin and thromboxane A2 from guinea pig or rat isolated lungs and endothelium-derived relaxing factor in the perfused mesentery of…”
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Vascular Hyporeactivity to Vasoconstrictor Agents and Hemodynamic Decompensation in Hemorrhagic Shock is Mediated by Nitric Oxide by Thiemermann, Christoph, Szabo, Csaba, Mitchell, Jane A., Vane, John R.

“…This study investigates the role of nitric oxide (NO) and the induction of a calcium-independent NO synthase (NOS) in development of vascular hyporeactivity to…”
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Mechanism of action of aspirin-like drugs by Vane, John R., Botting, Renia M.

“…Nonsteroid antiinflammatory drugs (NSAIDs) or aspirin-like drugs act by inhibiting the activity of the cyclooxygenase (COX) enzyme. Two isoforms of COX exist,…”
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Nitric Oxide is a Mediator of the Decrease in Cytochrome P450-Dependent Metabolism Caused by Immunostimulants by Khatsenko, Oleg G., Gross, Steven S., Rifkind, Arleen B., Vane, John R.

“…Bacterial lipopolysaccharide (LPS) and a diverse array of other immunostimulants and cytokines suppress the metabolism of endogenous and exogenous substances…”
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Attenuation of the Induction of Nitric Oxide Synthase by Endogenous Glucocorticoids Accounts for Endotoxin Tolerance in vivo by Szabo, Csaba, Thiemermann, Christoph, Wu, Chin-Chen, Perretti, Mauro, Vane, John R.

“…An enhanced formation of nitric oxide (NO) due to induction of a calcium-independent (inducible) NO synthase (iNOS) contributes importantly to the…”
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Mediators Produced by the Endothelial Cell by GRYGLEWSKI, RYSZARD J, BOTTING, REGINA M, VANE, JOHN R

“…This review discusses the role of three mediators, synthesized by vascular endotheiial cells, that help to keep the surface of the normal endotheliuin…”
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Human Neutrophils and Mononuclear Cells Inhibit Platelet Aggregation by Releasing a Nitric Oxide-Like Factor by Salvemini, Daniela, de Nucci, Gilberto, Gryglewski, Ryszard J., Vane, John R.

“…Incubation of neutrophils or mononuclear cells with washed platelets (all prepared from human venous blood) resulted in an inhibition of thrombin-induced…”
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The Croonian Lecture, 1993: The Endothelium: Maestro of the Blood Circulation by Vane, J. R.

“…The vascular endothelium plays a vital role in the control of the circulation. It metabolizes various vasoactive substances, coverts angiotensin I to…”
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Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock by Thiemermann, Christoph, Wu, Chin‐Chen, Szabó, Csaba, Perretti, Mauro, Vane, John R.

“…1 This study investigates the role of tumour necrosis factor (TNF) in the induction of nitric oxide synthase (NOS) by bacterial endotoxin (lipopolysaccharide;…”
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Nomenclature for COX-2 Inhibitors by Vane, JR, Warner, TD

“…Patrignani and colleagues' human in-vitro wholeblood assay5 has become an accepted and reproducible standard for measuring the effects of anti-inflammatory…”
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Use of the endothelin antagonists BQ‐123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF by Warner, Timothy D., Allcock, Graham H., Corder, Roger, Vane, John R.

“…1 We have compared the receptors mediating the contractions of rings of rat thoracic aorta or rabbit pulmonary artery and rat stomach strips in response to the…”
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Identification of Endothelin 1 and Big Endothelin 1 in Secretory Vesicles Isolated from Bovine Aortic Endothelial Cells by Harrison, V J, Barnes, K, Turner, A J, Wood, E, Corder, R, Vane, J R

“…Vesicles containing endothelin 1 (ET-1) were isolated from bovine aortic endothelial cells (BAECs) by fractionation of homogenates on sucrose density gradients…”
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